馬艷妮課題組

1.課題組簡(jiǎn)介

課題組研究方向為：從RNA代謝角度解析干細胞命運轉變、造血發(fā)育分化、疾病發(fā)生發(fā)展的基本規律，以期發(fā)掘RNA分子的新功能，鑒定RNA代謝新的調控分子，探索通過(guò)干預RNA代謝進(jìn)行疾病治療的新方法，并開(kāi)展疾病的RNA治療。

2.課題組負責人介紹

馬艷妮，女，1981年11月出生，北京協(xié)和醫學(xué)院準聘助理教授，研究員，博士生導師。2008年7月畢業(yè)于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2008-2011年于中國科學(xué)院生物物理研究所任助理研究員。2011年7月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生物化學(xué)與分子生物學(xué)系。獲國家“優(yōu)秀青年科學(xué)基金”（2022）、北京市“科技新星”(2017)、醫科院“青年醫學(xué)人才獎勵項目”（2018）、“協(xié)和新星” (2015)等人才計劃支持。作為負責人承擔國家自然科學(xué)基金委面上、青年項目，作為科研骨干參與科技部973項目、國家重點(diǎn)研發(fā)計劃。作為第一作者或通訊作者（含共同）在Cell Stem Cell、Developmental Cell、Blood、EMBO J（2015，2021）、Genome Research、Nature Communications、Mol Cell Bio等國際學(xué)術(shù)期刊發(fā)表多篇SCI研究論文。

E-mail: yanni_ma@126.com; mayanni@ibms.cams.cn

3.課題組成員介紹

劉思琪，博士，助理研究員

2020年于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所獲博士學(xué)位。2020-2023年于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所進(jìn)行博士后研究工作。2023年9月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所任助理研究員。作為負責人承擔國家自然科學(xué)基金委青年基金項目。作為第一作者（含共同）在Cell Stem Cell、Developmental Cell、Blood發(fā)表SCI論文3篇。主要研究方向為RNA與造血調控。

4.課題組主要科研項目

（1）國家優(yōu)秀青年科學(xué)基金，2022-2024、RNA與造血調控、主持。

（2）科技部國家重點(diǎn)研發(fā)計劃，2021-2026、靈長(cháng)類(lèi)原腸發(fā)育與器官形成的命運決定調控機制、科研骨干。

（3）科技部國家重點(diǎn)研發(fā)計劃，2019-2024、獲得性性狀通過(guò)母系傳遞的表觀(guān)遺傳機制、科研骨干。

（4）國家自然科學(xué)基金委面上項目，2020-2023、hnRNPLL調控造血干細胞發(fā)育及多能性維持的功能和機制研究、主持。

5.課題組代表性論文

1. Yanni Ma*, Zhongyang Chen, Jia Yu*. Pseudogenes and their potential functions in hematopoiesis. Experimental Hematology. 2021 Nov;103:24-29.

2. Fengjiao Wang?, Jiahuan He?, Siqi Liu?, Ai Gao, Liu Yang, Guohuan Sun, Wanqiu Ding, Chuanyun Li, Fanglin Gou, Manman He, Fang Wang, Xiaoshuang Wang, Xiangnan Zhao, Ping Zhu, Shao Hao, Yanni Ma*, Hui Cheng*, Jia Yu*, Tao Cheng*. Comprehensive RNA editome reveals edited Azin1 as a novel DDX1 partner to facilitate hematopoietic stem cell differentiation. Blood. 2021 Nov 18;138(20):1939-1952.

3. Yanni Ma?*, Siqi Liu?, Jie Gao?, Chunyan Chen?, Xin Zhang?, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Feb 22;56(4):478-493.e11.56(4):478–493.e11.

4. Xue Wang?, Changyun Ping?, Puwen Tan?, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729.

5. Kai Li?, Jiayue Xu?, Yanyun Luo?, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.

6. Jie Zhou?, Jiayue Xu?, Lingling Zhang?, Siqi Liu?, Yanni Ma?, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2):285-298.e5.

7. Zhengyi Zhang?, Jingnan P?, Dongling Zo?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Xianxie Zhang, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27;10(1):4397.

8. Yanni Ma?, Nan Yao?, Guang Liu?, Lei Dong, Fang Wang, Bin Wang, He Dong, Xueju Wei, Meili Zhang, Shaowei Ji, Yufang Liu, Junwu Zhang, Yangming Wang, Yue Huang*,Jia Yu*. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cell. The EMBO Journal. 2015 Feb 3. 34(3):361–378.

9. Yanni Ma?, Bin Wang?, Fengbing Jiang?, Dongsheng Wang?, Huiwen Liu, Yunmeng Yan, He Dong, Fang Wang, Bei Gong, Yong Zhu, Lei Dong, Haixin Yin, Zhongzu Zhang, Hualu Zhao, Zhikui Wu, Junwu Zhang, Jingguo Zhou, Jia Yu*. A Feedback Loop Consisting of MicroRNA 23a/27a and the Beta-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression. Molecular and Cellular Biology.2013 Oct; 33(20):3994-4007.