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會(huì)員登錄

用戶名:
密碼:

萬人計(jì)劃

陳厚早（青年拔尖人才）



陳厚早（Hou-Zao Chen），男，1978年出生，生化與分子生物學(xué)專業(yè)博士。中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所研究員，2013年破格為博士生導(dǎo)師。從事心血管疾病的發(fā)病機(jī)制的研究，側(cè)重聯(lián)系衰老和代謝研究表觀遺傳修飾酶在心血管疾病中的作用。率先闡述SIRTUIN1（SIRT1）在心血管系統(tǒng)的功能和作用分子機(jī)制，表明SIRTUIN家族分子可成為抗心血管疾病的潛在靶點(diǎn)；共發(fā)表SCI研究論文和綜述文章等70余篇，總影響因子已逾500分，包括通訊（含共同）發(fā)表Nat Cell Biol, J Exp Med, Circ, Eur Heart J, Aging Cell等30余篇，引用3000余次，授權(quán)專利4項(xiàng)，獲2 次F1000 推薦，Nat Cell Biol等5次同期評(píng)論。

E-Mail: chenhouzao@ibms.cams.cn; Tel: 8610-69156415.

 

主要發(fā)表文章

Corresponding author(selected)

  1. 1. Xiaoqiang Tang, PhD#; Xiao-Feng Chen, PhD#; Xin Sun, BSc#; Peng Xu, PhD; Xiang Zhao, BSc; Ying Tong, MSc; Xiao-Man Wang, PhD; Ke Yang, PhD; Yu-Tong Zhu, BSc; De-Long Hao, MSc; Zhu-Qin Zhang, PhD; De-Pei Liu, PhD*; Hou-Zao Chen, PhD* Short-chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis. Circulation. 2021 Mar 9;143(10):1066-1069. (*corresponding author)
  2. 2. Wang F, Chen HZ*. Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases. Front Pharmacol. 2020 Oct 6;11:537519 (*corresponding author)
  3. 3. Liu JF, Wu SF, Liu S, Sun X, Wang XM, Xu P*, Chen HZ*, Yang JT*. Global Lysine Crotonylation Profiling of Mouse Liver. Proteomics. 2020 Oct;20(19-20):e2000049. (*co-corresponding author)
  4. 4. Li PH, Zhang R, Cheng LQ, Liu JJ*, Chen HZ*. Metabolic regulation of immune cells in proinflammatory microenvironments and diseases during ageing. Ageing Res Rev. 2020 Sep 6:101165. (*co-corresponding author)
  5. 5. Tang X*, Li PH, Chen HZ*. Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments. Front Endocrinol (Lausanne). 2020 May 21;11:280. (*co-corresponding author)
  6. 6. Pei JF, Li XK, Li WQ, Gao Q, Zhang Y, Wang XM, Fu JQ, Cui SS, Qu JH, Zhao X, Hao DL, Ju D, Liu N, Carroll KS, Yang J, Zhang EE, Cao JM, Chen HZ*, Liu DP*. Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks. Nat Cell Biol. 2019 Dec;21(12):1553-1564. doi: 10.1038/s41556-019-0420-4. (*co-corresponding author)
  7. 7. Zhang R, Wang X, Qu JH, Liu B, Zhang P, Zhang T, Fan PC, Wang XM, Xiao GY, Su Y, Xie Y, Liu Y, Pei JF, Zhang ZQ, Hao DL, Xu P, Chen HZ*, Liu DP*. Caloric Restriction Induces MicroRNAs to Improve Mitochondrial Proteostasis. iScience. 2019 Jul 26;17:155-166. doi: 10.1016/j.isci.2019.06.028. (*co-corresponding author)
  8. 8. Zhou S, Tang X, Chen HZ*. Sirtuins and Insulin Resistance. Front Endocrinol (Lausanne). 2018 Dec 6;9:748. doi: 10.3389/fendo.2018.00748. eCollection 2018. Review. (*co-corresponding author)
  9. 9. Zhou S, Tang X, Chen HZ*. Sirtuins and Insulin Resistance. Front Endocrinol (Lausanne). 2018 Dec 6;9:748. doi: 10.3389/fendo.2018.00748. eCollection 2018. Review. (*co-corresponding author)
  10. 10. Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, Lu YB, Zhao X, Hao DL, Zhang ZQ, Zou MH, Liu DP*, Chen HZ*. SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. Circulation. 2017 Nov 21;136(21):2051-2067. (*co-corresponding author)
  11. 11. Luo YX, Tang X, An XZ, Xie XM, Chen XF, Zhao X, Hao DL, Chen HZ*, Liu DP*. Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J. 2017 May 7;38(18):1389-1398. (*co-corresponding author)
  12. 12. Liu Y, Wang TT, Zhang R, Fu WY, Wang X, Wang F, Gao P, Ding YN, Xie Y, Hao DL, Chen HZ*, Liu DP*. Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016 Oct 17;213(11):2473-2488. (*co-corresponding author)
  13. 13. Cheng LQ, Zhang ZQ, Chen HZ*, Liu DP*. Epigenetic regulation in cell senescence. J Mol Med (Berl). 2017 Sep 8. (*co-corresponding author)
  14. 14. Tang X, Chen XF, Chen HZ*, Liu DP*. Mitochondrial Sirtuins in cardiometabolic diseases. Clin Sci (Lond). 2017 Jul 24;131(16):2063-2078. (*co-corresponding author)
  15. 15. Yan YF, Pei JF, Zhang R, Wang F, Gao P, Zhang ZQ, Wang TT, Zhang Y, She ZG, Chen HZ*, Liu DP*. The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation. Arterioscler Thromb Vasc Biol. 2016 Dec 1. pii: ATVBAHA.116.308684. (*co-corresponding author)
  16. 16. Pei JF, Yan YF, Tang X, Zhang Y, Cui SS, Zhang ZQ, Chen HZ*, Liu DP*. Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice. Sci China Life Sci. 2016 Nov;59(11):1115-1122 (*co-corresponding author)
  17. 17. R Zhang, HZ Chen*, DP Liu*. The Four Layers of Aging. Cell Systems. 1, September 23, 2015. (*co-corresponding author)
  18. 18. Wan YZ, Gao P, Zhou S, Zhang ZQ, Hao DL, Lian LS, Li YJ, Chen HZ*, Liu DP*. SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence. Aging Cell. 2014 Oct;13(5):890-9. (*co-corresponding author)
  19. 19. Mu W, Zhang Q, Tang X, Fu W, Zheng W, Lu Y, Li H, Wei Y, Li L, She Z, Chen H*, Liu D*. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. Sci China Life Sci. 2014 Sep;57(9):915-24. (*co-corresponding author)
  20. 20. Liu Y, Chen H*, Liu D*. Mechanistic perspectives of calorie restriction on vascular homeostasis. Sci China Life Sci. 2014 Aug;57(8):742-54. doi: 10.1007/s11427-014-4709-z. (*co-corresponding author)
  21. 21. Xiaoqiang Tang, Yu-Xuan Luo, Hou-Zao Chen* and De-Pei Liu Mitochondria, Endothelial Cell Function and Vascular Diseases (invited Review). Frontiers in Physiology 2014 May 6;5:175. (*corresponding author)
  22. 22. Zhang Y, Xu J, Luo YX, An XZ, Zhang R, Liu G, Li H, Chen HZ*, Liu DP*. Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to Hypertrophic Stimuli. Antioxid Redox Signal. 2014 Oct 20;21(12):1693-707. (*co-corresponding author)
  23. 23. Gao P, Xu TT, Lu J, Li L, Xu J, Hao DL, Chen HZ*, Liu DP*. Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice. J Mol Med (Berl). 2014 Apr;92(4):347-57. (*co-corresponding author)
  24. 24. Zheng W, Lu YB, Liang ST, Zhang QJ, Xu J, She ZG, Zhang ZQ, Yang RF, Mao BB, Xu Z, Li L, Hao DL, Lu J, Wei YS, Chen HZ*, Liu DP*. SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes. Basic Res Cardiol. 2013 Jul;108(4):364. (*co-corresponding author)
  25. 25. Wang F, Chen HZ*, Lv X, Liu DP. SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-related Vascular Diseases (invited Review). Curr Mol Med. 2013 Jan;13(1):155-64.. (*co-corresponding author)
  26. 26. Jia Y, Gao P, Chen H*, Wan Y, Zhang R, Zhang Z, Yang R, Wang X, Xu J, Liu D*. SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells. Sci China Life Sci. 2013 Jan;56(1):19-25. (*co-corresponding author)

 

First author (selected)

1. Chen HZ, Wang F, Gao P, Pei JF, Liu Y, Xu TT, Tang X, Fu WY, Lu J, Yan YF, Wang XM, Han L, Zhang ZQ, Zhang R, Zou MH, Liu DP. Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. Circ Res. 2016 Oct 28;119(10):1076-1088

2. Chen HZ, Wan YZ, Liu DP. Cross-talk between SIRT1 and p66Shc in vascular diseases Trends Cardiovasc Med. 2013 Oct;23(7):237-41. (first author)

3. Chen H*, Wan Y, Zhou S, Lu Y, Zhang Z, Zhang R, Chen F, Hao D, Zhao X, Guo Z, Liu D, Liang C. Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence. Sci China Life Sci. 2012 Jun;55(6):467-73.

4. Zhou S*, Chen HZ*, Wan YZ*, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC. Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction. Circ Res. 2011 Sep 2;109(6):639-48. (*co-first author)

5. Zhang QJ*, Chen HZ*, Wang L, Liu DP, Hill JA, Liu ZP. The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest. 2011 Jun 1;121(6):2447-56. (*co-first author)

6. Li L*, Zhang HN*, Chen HZ*, Gao P, Zhu LH, Li HL, Lv X, Zhang QJ, Zhang R, Wang Z, She ZG, Zhang R, Wei YS, Du GH, Liu DP, Liang CC. SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res. 2011 May 13;108(10):1180-9. (*co-first author)

7. Zhang R*, Chen HZ*, Liu JJ, Jia YY, Zhang ZQ, Yang RF, Zhang Y, Xu J, Wei YS, Liu DP, Liang CC. SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem. 2010 Mar 5;285(10):7097-110. (*co-first author)

8. Zhang QJ*, Wang Z*, Chen HZ*, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res. 2008 Nov 1;80(2):191-9. (*co-first author)

 

Others (selected)

  1. 1. Ren C, Chen H, Chen HZ. First Case of Covid-19 in the United States. N Engl J Med. 2020 May 7;382(21):e53. doi: 10.1056/NEJMc2004794.
  2. 2. Fang X, Cai Z, Wang H, Han D, Cheng Q, Zhang P, Gao F, Yu Y, Song Z, Wu Q, An P, Huang S, Pan J, Chen HZ, Chen J, Linkermann A, Min J, Wang F. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis.  Circ Res. 2020 Jul 31;127(4):486-501.
  3. 3. Wang Q, Ding Y, Song P, Zhu H, Okon I, Ding YN, Chen HZ, Liu DP, Zou MH. Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo. Circulation. 2017 Dec 5;136(23):2271-2283.
  4. 4. Zhang YK, Qu YY, Lin Y, Wu XH, Chen HZ, Wang X, Zhou KQ, Wei Y, Guo F, Yao CF, He XD, Liu LX, Yang C, Guan ZY, Wang SD, Zhao J, Liu DP, Zhao SM, Xu W. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients. Nat Commun. 2017 Sep 6;8(1):464.

 

專著：

劉德培、陳保生、黎健、解用紅、方定志、宋保亮、鄭芳、陳厚早，生物化學(xué)與分子生物學(xué)學(xué)科發(fā)展報(bào)告（脂質(zhì)與脂蛋白研究進(jìn)展），中國科學(xué)技術(shù)出版社, 360千字，2014。

“線粒體生物醫(yī)學(xué)：靶向線粒體防治人體重大疾病的研究”叢書《線粒體與心血管疾病》一書中的第十章節(jié)，唐小強(qiáng)，陳厚早《線粒體Sirtuins與心血管疾病》，高教基金國家出版基金項(xiàng)目資助。

Zhao Wang等《Aging and Age-Related Diseases》一書中的第四章節(jié)，Ding YN, Chen HZ*, Liu DP*，《 Epigenetic Regulation of Vascular Aging and Age-Related Vascular Diseases》，Springer Nature 出版社，2018。

授權(quán)專利：

  1. 1. SIRT1 在制備預(yù)防內(nèi)皮細(xì)胞功能失常導(dǎo)致的疾病藥物中的用途，ZL201010512403.6，發(fā)明專利，2013-10-23，中國。
  2. 2. PON基因簇在制備用于動(dòng)脈粥樣硬化的藥物中的用途，ZL100910081109.9，發(fā)明專利，2015-04-08，中國。
  3. 3. Immt基因敲除小鼠的培育方法及改小鼠模型的用途，ZL201010186473.7，發(fā)明專利，2013-10-25，中國。
  4. 4.三羥基黃酮在制備用于預(yù)防和治療腹主動(dòng)脈瘤的藥物中的用途，ZL201410184290.X，發(fā)明專利，2017-11-21，中國。

 

主要學(xué)術(shù)任職：

2012/04-至今 Frontiers in Physiology 雜志編委

2018/01-至今 Cardiovascular Drugs and Therapy雜志編委

2020/01-至今 Free Radical Biology and Medicine雜志編委

2020/10-至今 Mechanisms of Ageing and Development雜志編委

2012/07-至今 中國生物化學(xué)與分子生物學(xué)學(xué)會(huì)脂質(zhì)與脂蛋白委員會(huì)

       青年委員會(huì)副主任委員/主任委員

2013/04-至今 中國老年學(xué)學(xué)會(huì)衰老與抗衰老科學(xué)委員會(huì)委員

2018/04-至今 中國藥理學(xué)會(huì)表觀遺傳藥理學(xué)專業(yè)委員會(huì)副主任委員

 

主要人才項(xiàng)目和榮譽(yù)：

    2021年獲得“第九屆國家衛(wèi)生健康突出貢獻(xiàn)中青年專家”

    2019年獲得“中組部國家萬人計(jì)劃領(lǐng)軍人才”

    2018年獲得“科技部中青年科技創(chuàng)新領(lǐng)軍人才”

    2016年獲得“教育部青年長江學(xué)者”

    2015年獲得“中組部青年拔尖人才”

    2014年獲得“國家自然科學(xué)優(yōu)秀青年基金項(xiàng)目”

    2013年獲得“北京市科技新星”

    2011年獲得“協(xié)和新星”

 

主要在研科研課題：

  1. 1.國家自然科學(xué)基金重點(diǎn)項(xiàng)目，82030017，平滑肌細(xì)胞異質(zhì)性改變在散發(fā)型胸主動(dòng)脈瘤發(fā)病中的作用以及表觀機(jī)制研究，2021.01-2025.12，297萬，在研，主持。
  2. 2.科技部國家重點(diǎn)研發(fā)計(jì)劃，2020YFC2008003，血管的衰老與鈣化的分子機(jī)制，2021.01-2022.12, 259萬，在研, 課題組長。
  3. 3.科技部國家重點(diǎn)研發(fā)計(jì)劃，2019YFA0801500，心臟和肝臟更新能力差異的細(xì)胞和分子基礎(chǔ)，2020.01-2024.12, 242萬，在研, 課題骨干。