王琳

王琳課題組

王琳，研究員、博士研究生導師，院校準-長(cháng)聘教職引進(jìn)人才。2015年6月畢業(yè)于浙江大學(xué)化學(xué)系，獲理學(xué)博士學(xué)位。2015年9月進(jìn)入北京工業(yè)大學(xué)從事單細胞質(zhì)譜分析方向的研究。2017年加入美國普林斯頓大學(xué)從事博士后研究，并于2021年11月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所&北京協(xié)和醫學(xué)院基礎學(xué)院，課題組隸屬于醫學(xué)分子生物國家重點(diǎn)實(shí)驗室，入選國家級青年人才項目。

研究方向：

       課題組主要研究領(lǐng)域為代謝組學(xué)及空間分辨的代謝成像。相關(guān)成果已在Nature、Nature Metabolism、Nature Methods、Cell Metabolism、Analytical Chemistry等專(zhuān)業(yè)期刊發(fā)表論文30余篇，其中第一作者/通訊作者論文11篇，授權中國專(zhuān)利4項。近期課題組研究方向包括：

（1）靶向定量代謝組學(xué)及非靶向代謝分析。

（2）基于質(zhì)譜成像技術(shù)的空間分辨代謝及代謝流研究：將代謝信息由濃度擴展到代謝通量，由一維器官之間的分布擴展到二維器官內分布及三維細胞間分布，深入揭示我們的代謝變化“在哪里發(fā)生”、“如何發(fā)生”以及“如何調控”，拓展對疾病發(fā)生、發(fā)展等生物過(guò)程的認知。

（3）開(kāi)展基于人群隊列生物樣本的高通量多組學(xué)分析：注重多組學(xué)技術(shù)和生物信息學(xué)方法的融合，發(fā)現及鑒定新的潛在的疾病代謝物和代謝靶點(diǎn)，研究其與疾病發(fā)生發(fā)展的關(guān)系及作用機理。

課題組招聘：

       2023年度課題組計劃在基礎生物學(xué)、生物化學(xué)、生物信息學(xué)、化學(xué)或生物物理方向招聘1名助理研究員（事業(yè)編制）、1名技術(shù)崗工作人員。課題組鼓勵工作人員獨立申請和完成科研項目。

       同時(shí)，課題組長(cháng)期招收博士研究生/碩士研究生。課題組及所在研究所具有先進(jìn)的質(zhì)譜技術(shù)平臺，與哈佛大學(xué)、普林斯頓大學(xué)、匹茲堡大學(xué)等多所學(xué)校合作緊密，可為研究生提供合理完善的培養條件。歡迎對交叉學(xué)科研究感興趣的同學(xué)聯(lián)系我們。

聯(lián)系方式：

linwang@ibms.pumc.edu.cn

北京市東城區東單三條17號樓

近五年代表性論文：

1. 1. Zeng, X., Xing, X., Gupta, M., Keber, F. C., Lopez, J. G., Lee, Y. J., Roichman, A., Wang, L., Neinast, M. D., Donia, M. S., Wühr, M., Jang, C., Rabinowitz, J. D.*, Gut bacterial nutrient preferences quantified in vivo. Cell, 2022, 185: 3441-3456.
2. 2. Yang, L., TeSlaa, T., Ng, S., Nofal, M., Wang, L., Lan, T., Zeng, X., Cowan, A., McBride, M., Lu, W., Davidson, S., Liang, G., Oh, T. G., Downes, M., Evans, R., Von Hoff, D., Guo, J. Y., Han, H., Rabinowitz, J. D., Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med, 2022, 3: 119-136.
3. 3. Wang, L., Xing, X., Zeng, X. F., Jackson, S. R., TeSlaa, T., Wolff, J., Yang, L. F., McReynolds, M. R., Li, X., Rabinowitz, J. D.,* Davidson, S. M.,* Spatially-resolved isotope tracing reveals tissue metabolic activity. Nature Methods, 2022, 19: 223-230.

4. 4. Chen, L., Lu, W., Wang, L., Xing, X., Chen, Z., Teng, X., Zeng, X., Muscarella, A. D., Shen, Y., Cowan, A., McReynolds, M. R., Kennedy, B. J., Lato, A. M., Campagna, S. R., Singh, M., Rabinowitz, J. D.,* Metabolite discovery through global annotation of untargeted metabolomics data. Nature Methods, 2021, 18, 1377-1385.
5. 5. Ghergurovich, J. M., Xu, X., Wang, J. Z., Yang, L., Ryseck, R., Wang, L., Rabinowitz, J. D.,* Methionine synthase supports tumour tetrahydrogolate pools. Nature Metabolism, 2021, 3, 1512-1520.
6. 6. Parkhitko A. A.,* Wang, L., Filine, E., Jouandin, P., Leshchiner, D., Binari, R., Asara, J. M., Rabinowitz, J. D., Perrimon, N.,* A genetic model of methionine restriction extends Drosophila health and lifespan. Proc. Natl. Acad. Sci U S A, 2021, 118, e2110387118.
7. 7. TeSlaa, T., Bartman, C. R., Jankowski, C., Zhang, Z., Xu, X., Xing, X., Wang, L., Lu, W., Hui, S., Rabinowitz, J. D.,* The source of glycolytic intermediates in mammalian tissues. Cell Metabolism, 2021, 33, 367-378.
8. 8. Barekatain, Y., Ackroyd, J. J., Yan, V. C., Khadka, S., Wang, L., Chen, K., Poral, A. H., Tran, T., Georgiou, D. K., Arthur, K., Lin, Y., Satani, N., Ballato, E. S., Behr, E. I., Verhaak, R., Huse, J. T., Asara, J. M., Kalluri, R., Muller, F. L.*, Nature Communications, 2021, 4228, DOI: 10.1038/s41467-021-24240-3.

9. 9. Luongo, T. S., Eller, J. M., Lu, M-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., Migaud, M. E., Rabinowitz, J. D., Johnson, F. B., Johnsson K., Ziegler, M., Cambronne, X. A., Baur, J. A.,* SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature, 2020, 588, 174-179.
10. 10. Green, R., Wang, L., Hart, S. F. M., Lu, W., Shelding, D., Burton, J. C., Mi, H., Capel, A., Chen, H. A., Lin, A., Subramaniam, A. R., Rabinowitz, J. D., Shou, W.,* Metabolic excretion associated with nutrient growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biology, 2020, 18, e3000757.
11. 11. Hui, S.,* Cowan, A. J., Zeng X., Yang, L., TeSlaa, T., Li, X., Bartman, C., Zhang, Z., Jang, C., Wang, L., Lu, W., Rojas, J., Baur, J., Rabinowitz, J. D.,* Quantitative fluxomics of circulating metabolites. Cell Metabolism, 2020, 32, 676-688.
12. 12. Shen, K. X., Wang, L., He, Q., Jin, Z., Chen, W. Y., Sun, C. R.,* Pan, Y. J. Sensitive bromine-labeled probe D-BPBr for simultaneous identification and quantification of chiral amino acids and amino containing metabolites profiling in human biofluid by HPLC/MS. Analytical Chemistry. 2020, 92, 2, 1763-1769.
13. 13. Yang, L. F., Canaveras, J. C. G., Chen, Z. H., Wang, L., Jang, C., Morsher, R. J., Zhang, Z. Z., Ghergurovich, J. M., Su, X. Y., Mayr, J. A., Rabinowitz, J. D.,* Serine catabolism feeds NADH when respiration is impaired. Cell Metabolism, 2020, 31(4), 809-821.

14. 14. Liu, Z., Shao, Y. L., Wang, L.,* Gas phase reaction between chromones and solvent in an electrospray ionization source. Journal of Mass Spectrometry. 2019, 54, 66-72.
15. 15. Benson, K. K., Hu, W., Weller, A. H., Chen, E. R., Khetarpal, S. A., Yoshino, S., Bone, W. P., Wang, L., Rabinowitz, J. D., Voight, B. F., Soccio, R. E.* Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene. Proc Natl Acad Sci USA, 2019, 116: 23232-23242.  
16. 16. Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Mrscher, R. J., Reyes, J., Frezza,C., Hwang, H. Y., Imai, A., Saito, Y., Okamoto, K., Vaspoli, C., Kasprenski, L., Zsido, G. A., Gorman, J. H., Gorman, R. C., Rabinowitz, J. D.,* Metabolite exchange between mammalian organs quantified in pigs. Cell Metabolism, 2019, 30(3): 594-606.

17. 17. Wang, L., Xing, X., Chen, L., Yang, L., Su, X., Rabitz, H. A., Lu, W.,* Rabinowitz, J. D.,* Peak annotation and verification engine (PAVE) for untargeted LC-MS metabolomics. Analytical Chemistry, 2018, 91(3): 1838-1846.
18. 18. Lu, W., Wang, L., Chen, L., Hui, S., Rabinowitz, J. D.,* Extraction and quantitation of nicotinamide adenine dinucleotide redox cofactors. Antioxid Redox Signal. 2018, 28, 167-179.
19. 19. Wang, L., Zhe, J., Wang, X., Zeng, S., Sun, C.,* Pan, Y.* Pair of stereodynamic chiral benzylicaldehyde probes for determination of absolute configuration of amino acid residues in peptides by mass spectrometry. Analytical Chemistry, 2017, 89, 11902-11907.