于洋
工作履歷
2019-至今 副研究員，中國醫學(xué)科學(xué)院基礎醫學(xué)研究所，生化與分子生物學(xué)系
2014-2019 博士后，Sloan Kettering Institute， Eric Lai實(shí)驗室
研究領(lǐng)域與方向
神經(jīng)干細胞經(jīng)歷了精確的基因表達變化才最終發(fā)育成復雜的神經(jīng)系統。我們實(shí)驗室綜合利用分子生物學(xué)、生物化學(xué)、細胞生物學(xué)、小鼠遺傳學(xué)、生物信息學(xué)手段，研究神經(jīng)發(fā)育過(guò)程中基因表達的轉錄調控和轉錄后調控機制。具體而言，我們關(guān)注以下問(wèn)題：（1）神經(jīng)發(fā)育相關(guān)的基因如何被轉錄激活和抑制；（2）這些基因在轉錄成RNA之后如何被識別、監測和調控；（3）這些精巧的生物學(xué)過(guò)程如何做被在特定亞神經(jīng)細胞結構內（例如軸突或突觸）內發(fā)生；（4）在異常狀態(tài)下（例如腫瘤），神經(jīng)基因會(huì )在其他組織中表達、修飾、并引發(fā)嚴重疾病（如副腫瘤綜合征），那么病變的細胞內基因調控發(fā)生了哪些缺陷才導致神經(jīng)基因的異位表達？
聯(lián)系方式
yuy@@ibms.pumc.edu.cn
北京市東城區東單三條五號|中國醫學(xué)科學(xué)院基礎醫學(xué)研究所老科研樓452室|郵編100005
代表性論文
- Pan, A. *, Zeng, Y. *, Liu, J. *, Zhou, M., Lai, E.C., and Yu, Y. (2023). Unanticipated broad phylogeny of BEN DNA-binding domains revealed by structural homology searches. Curr Biol 33, 2270-2282 e2272
- Zheng L*, Liu J.*, Niu L, Kamran M, Yang AWH, Jolma A, Dai Q, Hughes TR, Patel DJ, Zhang L, Prasanth SG, Yu, Y.#, Ren A#, Lai EC# (2022) Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins. Genes Dev (#Co-corresponding author) PMID: 3514496
- Yu, Y.#, Andreu-Agullo, C., Liu, B., Barboza, L., Toth, M., Lai, E#. (2020). Regulation of embryonic and adult neurogenesis by Ars2. Development 147:dev180018. (#Co-corresponding author). PMID: 31969356.
- Yu, Y.*, Chen, Y.*, Kim, B.*, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR. (2013). Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell 152, 248-261. (*Co-first author). PMID: 23332759.
- Wang JJ, Lee J., Riemondy K., Yu Y, Marquez S., Lai E., and Yi R (2020). XPO5 promotes primary miRNA processing independently of RanGTP. Nature Communications
- Lv X, Ren SQ, Zhang XJ, Shen Z, Ghosh T, Xianyu A, Gao P, Li Z, Lin S, Yu Y, Zhang Q, Groszer M, Shi SH (2019). TBR2 coordinates neurogenesis expansion and precise microcircuit organization via Protocadherin 19 in the mammalian cortex. Nature Communications 10, 3946. PMID: 31477701.
- He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, Burns DK, Kim SH, Kool M, Pfister SM, Weinstein LS, Pomeroy SL, Gilbertson RJ, Rubin JB, Hou Y, Wechsler-Reya R, Taylor MD, Lu QR (2014). The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nature Medicine 20, 1035-1042. PMID:25150496
- He, X*., Yu, Y*., Awatramani, R., and Lu, Q.R. (2012). Unwrapping myelination by microRNAs. The Neuroscientist 18, 45-55. (*Co-first author, Review)
- Yu, Y., Casaccia, P., and Lu, Q.R. (2010). Shaping the oligodendrocyte identity by epigenetic control. Epigenetics 5, 124-128. (Review)
- Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, Hoang T, Xu X, Mi QS, Xin M, Wang F, Appel B, Lu QR. (2010). MicroRNA-mediated control of oligodendrocyte differentiation. Neuron 65, 612-626. PMID: 20223198.
實(shí)驗室成員
? 管理與技術(shù)人員 郭蓉 (guorong329@@126.com)
孫倩倩 (1604805890@qq.com)
? 研究生與實(shí)習生 申屠杰益，賈富釧，潘安宇，夏宇，劉靜靜，曾揚帆
