本課題組由張俊武研究員建立于1993年，承擔(dān)過國家七.五、863、基礎(chǔ)研究重大前期專項、973、重大科學(xué)計劃、美國中華醫(yī)學(xué)基金（CMB）、國家自然科學(xué)基金重大項目和面上項目等，在1990-2010近二十年間重點研究珠蛋白基因表達調(diào)控、造血相關(guān)基因功能及機制及老年性癡呆（AD）相關(guān)基因，已畢業(yè)博士33人，碩士6人。共發(fā)表論文130多篇（SCI 44篇）。2012年，余佳研究員接任課題組長，聚焦“RNA和干細(xì)胞生物學(xué)”，重點關(guān)注RNA和遺傳信息傳遞如何影響干細(xì)胞命運決定、造血譜系分化及相關(guān)疾病，以期為人類疾病的細(xì)胞治療、靶向治療及成分輸血提供理論基礎(chǔ)和新方向。通過近十年努力，課題組建立了成熟的干細(xì)胞培養(yǎng)及移植平臺、RNA實驗平臺、組學(xué)及計算平臺；培養(yǎng)了一批科研骨干及生物信息學(xué)團隊；并與國內(nèi)外多個領(lǐng)域內(nèi)一流實驗室建立了緊密合作關(guān)系、共享研究資源、共同培養(yǎng)研究生與博士后。現(xiàn)有工作人員包括：余佳（教授）、 張俊武（研究員）、王芳（教授）、馬艷妮（研究員）、王小爽（副研究員）、趙華路（副主任技師）、徐嘉悅（助理研究員）、高玉風(fēng)（助理研究員）、司艷敏（技術(shù)員）、果月紅（技術(shù)員）、博士后4人（劉思琪、李衛(wèi)倩、何家驩、孫晨光），在讀博士研究生11人，碩士研究生10人。課題組既有豐富的歷史沉淀，又年輕而朝氣蓬勃，學(xué)術(shù)氣氛積極向上，致力于成為“嚴(yán)謹(jǐn)、求實、快樂、奮進”的研究團隊。歡迎各位有志于科學(xué)研究、對干細(xì)胞及RNA生物學(xué)感興趣的考生報考。

     余佳，博士，長聘教授（長準(zhǔn)聘系列），研究員，課題組長

     國家杰出青年科學(xué)基金獲得者

     醫(yī)學(xué)分子生物學(xué)國家重點實驗室

     中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所&北京協(xié)和醫(yī)學(xué)院基礎(chǔ)學(xué)院

     E-mail: j-yu@ibms.pumc.edu.cn; yujia_new@msn.com

個人簡介

余佳，男，1978年生，研究員，博士生導(dǎo)師，北京協(xié)和醫(yī)學(xué)院長聘教授（首批）、RNA與干細(xì)胞生物學(xué)課題組組長，中國醫(yī)學(xué)科學(xué)院RNA與造血調(diào)控研究重點實驗室主任，醫(yī)學(xué)分子生物學(xué)國家重點實驗室PI。獲得國家杰出青年科學(xué)基金(2017，生命科學(xué)部)，長江學(xué)者獎勵計劃(2017)，百千萬人才工程國家級人選（2019），國務(wù)院政府特殊津貼（2020）等人才項目支持。擔(dān)任科技部十三五“發(fā)育編程及其代謝調(diào)節(jié)”重點研發(fā)專項首席科學(xué)家，十四五“發(fā)育編程及其代謝調(diào)節(jié)”重點研發(fā)專項總體專家組、指南編寫組成員。2006年7月畢業(yè)于中國醫(yī)學(xué)科學(xué)院/北京協(xié)和醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2006-2007年在美國伊利諾伊大學(xué)芝加哥分校工作(Post-doc)。2007-2009年在美國西北大學(xué)Feinberg醫(yī)學(xué)院工作(Post-doc)。2009年10月回國加入中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化系及醫(yī)學(xué)分子生物學(xué)國家重點實驗室。作為負(fù)責(zé)人承擔(dān)國家自然科學(xué)基金委重大研究計劃、重點項目及面上項目等；作為負(fù)責(zé)人承擔(dān)科技部國家重點研發(fā)計劃、973子課題及國家重大研究計劃。余佳博士同時擔(dān)任中國醫(yī)學(xué)科學(xué)院-以色列Weizmann研究所聯(lián)合實驗室PI，中國醫(yī)學(xué)科學(xué)院“醫(yī)學(xué)與健康科技創(chuàng)新工程”創(chuàng)新團隊項目首席科學(xué)家，人血細(xì)胞分子圖譜（ABC）研究聯(lián)盟首批倡議及參加成員。余佳實驗室主要興趣集中在造血調(diào)控、干細(xì)胞命運及轉(zhuǎn)化醫(yī)學(xué)，綜合運用多種組學(xué)及計算生物學(xué)方法，干細(xì)胞培養(yǎng)及基因操縱等體外實驗技術(shù)，干細(xì)胞移植、基因敲除小鼠及譜系示蹤等體內(nèi)技術(shù)，結(jié)合生化與分子生物學(xué)手段，研究RNA、互作蛋白質(zhì)及相關(guān)遺傳信息傳遞過程在干細(xì)胞或疾病中的功能和調(diào)控機理。在組織器官發(fā)育與疾病的細(xì)胞圖譜、非編碼RNA生成與加工新機理、干細(xì)胞命運調(diào)控新機制等方面取得突出成果，相關(guān)研究成果作為通訊作者（含共同）在Cell Stem Cell、Developmental Cell、Blood、Cell Research、Science Advances、EMBO Journal（2015，2021）、Genome Research、Nature Communications（2017，2019）、Genome Biology 、Cancer Research（2010，2015，2020）、Nucleic Acids Research（2013，2014，2017，2020）、Autophagy、Oncogene、MCB等國際主流學(xué)術(shù)期刊上發(fā)表SCI論文30余篇，被引用4000余次。獲教育部自然科學(xué)二等獎（2018）。現(xiàn)擔(dān)任中國生理學(xué)會血液生理專業(yè)委員會理事，中國細(xì)胞生物學(xué)會干細(xì)胞專業(yè)委員會理事， 北京市生化協(xié)會理事。擔(dān)任Blood, Nature Communications, Nucleic Acids Research, Oncogene, Cancer Research, MCB, JBC等雜志特邀審稿人。

研究方向 

RNA與干細(xì)胞生物學(xué)

研究工作簡介

              RNA生物學(xué)是系統(tǒng)認(rèn)識和研究各種RNA的生物發(fā)生、分子特征、生物學(xué)功能和分子機理的一門學(xué)科，也是生命科學(xué)領(lǐng)域的新興學(xué)科。過去二十年里，這一學(xué)科得到長足發(fā)展，特別是高通量測序技術(shù)的出現(xiàn)不但幫助發(fā)現(xiàn)了更多編碼RNA的特征，而且鑒定了多種非編碼RNA分子，是目前國際上最前沿的領(lǐng)域之一。干細(xì)胞生物學(xué)也是目前國際上最前沿和挑戰(zhàn)最大的領(lǐng)域之一。闡明干細(xì)胞自我更新和分化的調(diào)控機理可為再生醫(yī)學(xué)和癌癥治療提供重要支撐。以RNA為切入點研究干細(xì)胞生物學(xué)具有獨特優(yōu)勢：i. 以往被視為遺傳信息傳遞中間站的messenger RNA (mRNA)其實具有遠超我們所理解的轉(zhuǎn)錄后調(diào)控方式，如RNA編輯、RNA修飾、RNA穩(wěn)定性調(diào)節(jié)、RNA選擇性剪接及RNA選擇性加帽或加尾等，這些方式均會引起相應(yīng)的基因表達變化，從而最終改變遺傳信息從DNA向蛋白質(zhì)的共線性傳遞。近期關(guān)于RNA修飾的研究已經(jīng)衍生出RNA表觀遺傳學(xué)這一學(xué)科方向，也誕生了表觀轉(zhuǎn)錄組（Epitranscriptome）概念；ii. RNA組學(xué)，特別是單細(xì)胞RNA組學(xué)的發(fā)展，使我們可以精確描繪發(fā)育層級的分子動力學(xué)圖譜，從而推動了目前中國、美國及歐洲的人類細(xì)胞圖譜計劃；iii. ENCODE計劃最重要的貢獻之一：非編碼RNA的大量發(fā)現(xiàn)，更是大大擴充了人類對于自身，乃至各個物種基本遺傳和進化的認(rèn)知。但該計劃也提出了未來多個重要的挑戰(zhàn)，即各種各樣的非編碼RNA的分子特征是什么，是否具有重要的生物學(xué)功能，有什么獨特的分子調(diào)控機制，在轉(zhuǎn)化醫(yī)學(xué)中是否有應(yīng)用價值？

課題組主攻下列科學(xué)問題：

1、造血干細(xì)胞起源、異質(zhì)性、譜系分化與生態(tài)的分子動力學(xué)圖譜；

2、非編碼RNA加工與成熟的分子機制及其在干細(xì)胞分化與相關(guān)疾病中的作用機理；

3、胚胎及成體干細(xì)胞功能的RNA調(diào)控機理；

4、RNA代謝及調(diào)控的生理功能和轉(zhuǎn)化醫(yī)學(xué)應(yīng)用。 

代表性研究成果簡介

一、細(xì)胞與生態(tài)圖譜

1. 1. 利用深度RNA-sequencing結(jié)合全基因組DNA-sequencing繪制出造血譜系RNA編輯圖譜，發(fā)現(xiàn)調(diào)控造血干細(xì)胞分化的關(guān)鍵編輯基因及其入核后的轉(zhuǎn)錄調(diào)控機理（Blood, 2021）；[被選為封面文章，USCD教授Catriona Jamieson 在Blood同期進行述評：Commentary: Upping the Antizyme: AZIN1 Directs Stem Cell Fate]
2. 2. 利用深度RNA-sequencing繪制出精子發(fā)育全程的lncRNA圖譜，鑒定功能性lncRNA及其轉(zhuǎn)錄調(diào)控機理（Genome Research, 2020）;
3. 3. 利用深度RNA-sequencing繪制出人垂體瘤轉(zhuǎn)錄組圖譜，結(jié)合外泌體分離與機器學(xué)習(xí)獲得首個侵襲性垂體瘤血液診斷panel并申請中國專利（Theranostics, 2020）;
4. 4. 利用單細(xì)胞測序技術(shù)繪制出造血干細(xì)胞發(fā)育全程的lncRNA及RNA剪接圖譜，揭示調(diào)控“內(nèi)皮-造血”轉(zhuǎn)換的關(guān)鍵lncRNA及RNA可變剪接事件（Cell Stem Cell, 2019； Science Advances 2022），[其中Cell Stem Cell文章被Faculty 1000推薦為必讀文章]；
5. 5. 利用RNA-sequencing繪制出造血干細(xì)胞向粒系/單核系分化命運選擇中的自噬分子圖譜（Autophagy, 2018）；
6. 6. 利用單細(xì)胞測序技術(shù)繪制出造血干細(xì)胞發(fā)育全程自噬分子圖譜（Autophagy, 2017）。

二、非編碼RNA生成、加工、成熟及功能

1. 1. 通過系統(tǒng)性調(diào)查假基因的表達特征及與疾病的關(guān)聯(lián)，發(fā)現(xiàn)假基因來源非編碼RNA-HBBP1演化出調(diào)控人紅細(xì)胞發(fā)育及疾病的重要作用及全新機制 （Developmental Cell, 2021）; [ISEH(國際實驗血液學(xué)會)官方雜志Experimental Hematology特邀余佳和馬艷妮教授撰寫領(lǐng)域展望：Perspective: Pseudogenes and their potential functions in hematopoiesis]
2. 2. 揭示腫瘤進程中部分microRNA存在雙臂表達的“arm imbalance”現(xiàn)象，發(fā)現(xiàn)“靶基因RNA引導(dǎo)的microRNA降解”可部分解釋其發(fā)生機制，提出靶向“microRNA雙臂”的腫瘤治療新策略（Nature Communications, 2019）;
3. 3. 解決了自microRNA發(fā)現(xiàn)以來的一個重要科學(xué)問題即microRNA初級轉(zhuǎn)錄本莖環(huán)結(jié)構(gòu)遠端序列是否具有調(diào)節(jié)功能？證明莖環(huán)遠端序列存在RNA順式作用元件，并且這些RNA順式作用元件可通過蛋白-RNA互作及其所介導(dǎo)RNA高級結(jié)構(gòu)參與microRNA加工（Cell Research, 2017）；
4. 4. 揭示一個或多個RNA順式作用元件通過蛋白-RNA互作及其所介導(dǎo)的RNA高級結(jié)構(gòu)參與microRNA加工，并調(diào)控造血干細(xì)胞分化 （Nature Communications, 2017）；
5. 5. 建立蛋白質(zhì)-RNA互作事件數(shù)據(jù)庫Raid 2.0 （Nucleic Acids Research, 2017）。

三、 干細(xì)胞命運調(diào)控

1. 1. 系統(tǒng)性揭示染色質(zhì)結(jié)合型RNA結(jié)合蛋白（Che-RBP）在造血干細(xì)胞分化中的蛋白質(zhì)/DNA及蛋白質(zhì)/RNA結(jié)合規(guī)律，發(fā)現(xiàn)Che-RBP QKI-5通過調(diào)控DNA轉(zhuǎn)錄促進單核細(xì)胞分化（Genome Biology. 2021）;
2. 2. 系統(tǒng)性揭示了RNA結(jié)合蛋白在胚胎干細(xì)胞多能性退出中的作用，發(fā)現(xiàn)hnRNPLL通過調(diào)控mRNA可變剪接促進胚胎干細(xì)胞退出多能性（The EMBO J. 2021）;
3. 3. 鑒定胚胎干細(xì)胞定向中胚層分化的關(guān)鍵microRNA基因簇并發(fā)現(xiàn)其“表型冗余”現(xiàn)象和產(chǎn)生機理 (The EMBO J. 2015)。

四、RNA代謝的生理功能和轉(zhuǎn)化醫(yī)學(xué)應(yīng)用

1. 1. 發(fā)現(xiàn)RNA結(jié)合蛋白介導(dǎo)的RNA修飾參與腫瘤發(fā)生，是腫瘤治療的新靶標(biāo)（Cancer Research, 2021; Nucleic Acids Research, 2020）；
2. 2. 鑒定了多個實體腫瘤發(fā)生發(fā)展相關(guān)的microRNA并闡明其致癌機理及轉(zhuǎn)化潛力  (Cancer Research, 2010, 2015; Carcinogenesis, 2014; Journal of Hepatology, 2010)；
3. 3. 鑒定了成體造血干細(xì)胞向髓系分化的關(guān)鍵microRNA基因/基因簇 (Blood, 2012；Cell Death&Differentiation, 2014)；
4. 4. 揭示microRNA與紅系分化關(guān)鍵轉(zhuǎn)錄因子間的多重互作機制 (Nucleic Acids Research, 2013, 2014; Mol. Cel. Biol, 2013)；發(fā)現(xiàn)RISC復(fù)合物成員Ago2介導(dǎo)的microRNA間"cross talk"是紅系分化的重要分子事件(Cell Research, 2011)；
5. 5. 鑒定了多個可用于急性髓系白血病診治的microRNA靶標(biāo)(Oncogene, 2015, 2016; PLoS Genetics, 2016)。

在研項目：

1. 1. 科技部國家重點研發(fā)計劃發(fā)育與代謝專項，2019-2024、造血穩(wěn)態(tài)的代謝調(diào)控機理、首席科學(xué)家。
2. 2. 國家杰出青年科學(xué)基金，2018-2022、造血細(xì)胞發(fā)育調(diào)控、主持。

代表性論著 (? first author; * corresponding author):

1. 1.Qing You?, Fang Wang?, Rong Du, Jingnan Pi, Huayi Wang, Yue Huo, Jingyi Liu, Chen Wang, Jia Yu*, Yanlian Yang*, Ling Zhu*. m6A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation. Adv Mater. 2022 Dec 9:e2204910.
2. 2.Hongwei Chen? , Xin Wen? , Shanshan Liu? , Tian Sun , Hua Song , Fang Wang , Jiayue Xu, Yueyang Zhang, Yuanjin Zhao, Jia Yu* , Lingyun Sun*. Dissecting Heterogeneity Reveals a Unique BAMBIhigh MFGE8high Subpopulation of Human UC-MSCs. Adv Sci (Weinh). 2022 Nov 14. 10(1):e2202510.
3. 3.Xueju Wei?, Yue Huo?, Jingnan Pi?, Yufeng Gao?, Shuan Rao?, Manman He?, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nature Cell Biology. 2022 Aug. 24(8):1278-1290.
4. 4.Fang Wang?, Puwen Tan?, Pengcheng Zhang?, Yue Ren?, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7;8(1):eabg5369.
5. 5.Yanni Ma?*, Zhongyang Chen, Jia Yu*. Pseudogenes and their potential functions in hematopoiesis. Experimental Hematology. 2021 Nov. 103:24-29.
6. 6.Fengjiao Wang?, Jiahuan He?, Siqi Liu?, Ai Gao, Liu Yang, Guohuan Sun, Wanqiu Ding, Chuanyun Li, Fanglin Gou, Manman He, Fang Wang, Xiaoshuang Wang, Xiangnan Zhao, Ping Zhu, Shao Hao, Yanni Ma*, Hui Cheng*, Jia Yu*, Tao Cheng*. A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021 Nov 18. 138(20):1939-1952.
7. 7.Yue Ren?, Yue Huo?, Weiqian Li?, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14 22(1).290.
8. 8.Jingnan Pi?, Wen Wang?, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10): 2651-2665.
9. 9.Yanni Ma?*, Siqi Liu?, Jie Gao?, Chunyan Chen?, Xin Zhang?, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Feb 22. 56(4):478-493.e11.
10. 10.Xue Wang?, Changyun Ping?, Puwen Tan?, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729.
11. 11.Kai Li?, Jiayue Xu?, Yanyun Luo?, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.
12. 12.Xinjie Bao?, Gengchao Wang?, Shan Yu?, Jian Sun, Hualu Zhao, Yanni Ma, Fang Wang, Xiaoshuang Wang*, Renzhi Wang*, Jia Yu*. Transcriptomic analysis reveals a tumor subtype-mRNA classifier for invasive non-functioning pituitary adenoma diagnostics. Theranostics. 2021 Jan 1. 11(1):132-146.
13. 13.Tao Liu?, Qinglv Wei?, Jing Jin?, Qingya Luo, Yi Liu, Yu Yang, Chunming Cheng, Lanfang Li, Jingnan Pi, Yanmin Si, Hualiang Xiao, Li Li, Shuan Rao, Fang Wang, Jianhua Yu, Jia Yu*, Dongling Zou*, Ping Yi*. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic Acids Research. 2020 Apr 17. 48(7):3816-3831.
14. 14.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
15. 15.Jie Zhou?, Jiayue Xu?, Lingling Zhang?, Siqi Liu?, Yanni Ma?, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2): 285-298.e5.
16. 16.Lintao Zhao?, Ran He?, Haixia Long?, Bo Guo?, Qingzhu Jia, Diyuan Qin, Si-Qi Liu, Zhongyu Wang, Tong Xiang, Jue Zhang, Yulong Tan, Jiani Huang, Junying Chen, Fang Wang, Minglu Xiao, Jianbao Gao, Xinxin Yang, Hao Zeng, Xinxin Wang, Chunyan Hu, Peter B. Alexander, Alistair L. J. Symonds, Jia Yu, Yisong Wan, Qi-Jing Li*, Lilin Ye*, Bo Zhu*. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nature Medicine. 2018 Oct. 24(10):1536–1544.
17. 17.Weiqian Li?, Yue Ren, Yanmin Si, Fang Wang*, Jia Yu*. Long non-coding RNAs in hematopoietic regulation. Cell Regen (London). 2018 Oct 11. 7(2):27-32. (Review)
18. 18.Hongmei Zhao?, Xiaoshuang Wang?, Ping Yi?, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428.
19. 19.Yongfei Hu?, Yan Huang, Ying Yi, Hongwei Wang, Bing Liu*, Jia Yu*, Dong Wang*. Single-cell RNA sequencing highlights transcription activity of autophagy-related genes during hematopoietic stem cell formation in mouse embryos. Autophagy. 2017 Apr 3. 13(4):770-771.
20. 20.Fang Wang?, Wei Song?, Hongmei Zhao?, Yanni Ma, Yuxia Li, Di Zhai, JingnanPi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar. 27(3):416-439.
21. 21.Ying Yi?, Yue Zhao, Chunhua Li, Lin Zhang, Huiying Huang, Yana Li, LanlanLiu, Ping Hou, Tianyu Cui, Puwen Tan, Yongfei Hu, Ting Zhang, Yan Huang, Xiaobo Li*, Jia Yu*, Dong Wang*. RAID v2.0: an updated resource of RNA-associated interactions across organisms. Nucleic Acids Research. 2017 Jan 4. 45(D1):D115-D118.
22. 22.Rui Su?, Lei Dong?, Dongling Zou, Hongmei Zhao, Yue Ren, Feng Li, Ping Yi, Lanfang Li, Yong Zhu, Yanni Ma, Jing Wang, Fang Wang*, Jia Yu*. MicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Nov 17. 35(46):6001-6014.
23. 23.Yanni Ma?, Nan Yao?, Guang Liu?, Lei Dong, Fang Wang, Bin Wang, He Dong, Xueju Wei, Meili Zhang, Shaowei Ji, Yufang Liu, Junwu Zhang, Yangming Wang, Yue Huang*, Jia Yu*. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cell. The EMBO Journal. 2015 Feb 3. 34(3):361–378.
24. 24.Jianan Gong?, Jianxiong Li, Yi Wang, Changzhegn Liu, Hongyan Jia, Chongliang Jiang, Yuxuan Wang, Min Luo, Hongmei Zhao, Lei Dong, Wei Song, Fang Wang, Weibin Wang, Junwu Zhang*, Jia Yu*. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis. 2014 Feb. 35(2):497-506.
25. 25.Fang Wang?, Yong Zhu?, Lihua Guo?, Lei Dong, Huiwen Liu, Haixin Yin, Zhongzu Zhang, Y Li, Changzheng Liu, Yanni Ma, Wei Song, Aibin He, Qiang Wang, Linfang Wang, Junwu Zhang, Jianxiong Li, Jia Yu*. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Research. 2014 Jan. 42(1):442-457.
26. 26.Yanni Ma?, Bin Wang?, Fengbing Jiang?, Dongsheng Wang?, Huiwen Liu, Yunmeng Yan, He Dong, Fang Wang, Bei Gong, Yong Zhu, Lei Dong, Haixin Yin, Zhongzu Zhang, Hualu Zhao, Zhikui Wu, Junwu Zhang, Jingguo Zhou, Jia Yu, Jia Yu*. A Feedback Loop Consisting of MicroRNA 23a/27a and the Beta-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression. Molecular and Cellular Biology. 2013 Oct. 33(20):3994-4007.
27. 27.Yong Zhu?, Dongsheng Wang?, Fang Wang?, Tingting Li, Lei Dong, Huiwen Liu, Yanni Ma, Fengbing Jiang, Haixin Yin, Wenting Yan, Ming Luo, Z Tang, Guoyuan Zhang, Qiang Wang, Junwu Zhang, Jingguo Zhou, Jia Yu*. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Research. 2013 Apr. 41(7):4129-43.
28. 28.Jia Yu*, Fang Wang. Recent progress in microRNA study: Benefits from technique advance. SCIENCE CHINA Life Sciences. 2012 July. 55(7):649-50. (Invited comment)
29. 29.Xiaoshuang Wang?, Jianan Gong?, Jia Yu, Fang Wang, Xinhua Zhang, Xiaolin Yin, Zhenqing Tan, Zimian Luo, Guihua Yang, Chao Shen, Junwu Zhang. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood. 2012 May 24. 119(21):4992-5004.
30. 30.Fang Wang?, Jia Yu, Guihua Yang, Xiaoshuang Wang, Junwu Zhang*. Regulation of erythroid differentiation by miR-376a and its targets. Cell Research. 2011 Aug. 21(8):1196-209.
31. 31.Jia Yu?, Han Peng?, Qing Ruan, Anees Fatima, Spiro Getsios, and Robert M. Lavker. MicroRNA-205 promotes keratinocyte migration via the lipidphosphatase SHIP2. The FASEB Journal. 2010 Oct. 24(10):3950-9.
32. 32.Shuangni Yu?, Zhaohui Lu, Changzheng Liu, Yunxiao Meng, Yihui Ma, Wugan Zhao, Jianping Liu, Jia Yu*, Jie Chen*. MiRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Research. 2010 Jul 15. 70(14):6015-25.
33. 33.Changzheng Liu?, Jia Yu?, Shuangni Yu, Robert M.Lavker, Lei Cai, Wei Liu, Kegong Yang, Xiaodong He, Songsen Chen. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. Journal of Hepatology. 2010 Jul. 53(1):98-107. (Cover story)
34. 34.Robert M. Lavker?*, Jia Yu and David G Ryan. The Tiny World of MicroRNAsin the Cross Hairs of the Mammalian Eye. Human Genomics. 2009 Jul. 3(4):332-348. (Review)
35. 35.Jia Yu?, David G. Ryan?, Spiro Getsios, Michelle Oliveira-Fernandes, Anees Fatima, and Robert M. Lavker. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proceedings of the National Academy of Sciences of the USA. 2008 Dec 9. 105(49):19300-5.

     馬艷妮

     博士，助理教授（長準(zhǔn)聘系列），研究員，博士生導(dǎo)師

     國家優(yōu)秀青年科學(xué)基金獲得者

     2015年度院校“協(xié)和新星”，2017年度北京市“科技新星”

     E-mail: yanni_ma@126.com，mayanni@ibms.cams.cn

個人簡介

馬艷妮，女，1981年11月出生，北京協(xié)和醫(yī)學(xué)院準(zhǔn)聘助理教授，研究員，博士生導(dǎo)師。2008年7月畢業(yè)于中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2008-2011年于中國科學(xué)院生物物理研究所任助理研究員。2011年7月加入中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，醫(yī)學(xué)分子生物學(xué)國家重點實驗室工作。作為負(fù)責(zé)人承擔(dān)國家自然科學(xué)基金委面上、青年項目，作為科研骨干參與科技部973項目、國家重點研發(fā)計劃。獲國家“優(yōu)秀青年科學(xué)基金”（2022）、北京市“科技新星”(2017)、醫(yī)科院“青年醫(yī)學(xué)人才獎勵項目”（2018）、 “協(xié)和新星” (2015)等人才計劃支持。作為第一作者或通訊作者（含共同）在Cell Stem Cell、Developmental Cell、Blood、EMBO J（2015，2021）、Genome Research、Nature Communications、Mol Cell Bio等國際學(xué)術(shù)期刊發(fā)表SCI論文14篇。

目前研究方向為RNA代謝在多能干細(xì)胞、造血干細(xì)胞功能維持及分化中的調(diào)控機制研究。

在研項目：

1. 1. 科技部國家重點研發(fā)計劃發(fā)育與代謝專項，2019-2024、獲得性性狀通過母系傳遞的表觀遺傳機制、科研骨干。
2. 2. 國家優(yōu)秀青年科學(xué)基金，2022-2024、RNA與造血調(diào)控、主持。
3. 3. 國家自然科學(xué)基金委面上項目，2020-2023、hnRNPLL調(diào)控造血干細(xì)胞發(fā)育及多能性維持的功能和機制研究、主持。
4. 4. 國家自然科學(xué)基金委面上項目，2018-2021、長非編碼RNA BGLT3激活胎兒期血紅蛋白的功能及機制研究、主持。

代表性論著 (? first author; * corresponding author):

1. 1.Yanni Ma?*, Zhongyang Chen, Jia Yu*. Pseudogenes and their potential functions in hematopoiesis. Experimental Hematology. 2021 Nov. 103:24-29.
2. 2.Fengjiao Wang?, Jiahuan He?, Siqi Liu?, Ai Gao, Liu Yang, Guohuan Sun, Wanqiu Ding, Chuanyun Li, Fanglin Gou, Manman He, Fang Wang, Xiaoshuang Wang, Xiangnan Zhao, Ping Zhu, Shao Hao, Yanni Ma*, Hui Cheng*, Jia Yu*, Tao Cheng*. Comprehensive RNA editome reveals edited Azin1 as a novel DDX1 partner to facilitate hematopoietic stem cell differentiation. Blood. 2021 Nov 18. 138(20):1939-1952.
3. 3.Yanni Ma?*, Siqi Liu?, Jie Gao?, Chunyan Chen?, Xin Zhang?, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Feb 22. 56(4):478-493.e11.56(4):478–493.e11.
4. 4.Xue Wang?, Changyun Ping?, Puwen Tan?, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729.
5. 5.Kai Li?, Jiayue Xu?, Yanyun Luo?, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.
6. 6.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
7. 7.Jie Zhou?, Jiayue Xu?, Lingling Zhang?, Siqi Liu?, Yanni Ma?, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2):285-298.e5.
8. 8.Yanni Ma?, Nan Yao?, Guang Liu?, Lei Dong, Fang Wang, Bin Wang, He Dong, Xueju Wei, Meili Zhang, Shaowei Ji, Yufang Liu, Junwu Zhang, Yangming Wang, Yue Huang*, Jia Yu*. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cell. The EMBO Journal. 2015 Feb 3. 34(3):361–378.
9. 9.Yanni Ma?, Bin Wang?, Fengbing Jiang?, Dongsheng Wang?, Huiwen Liu, Yunmeng Yan, He Dong, Fang Wang, Bei Gong, Yong Zhu, Lei Dong, Haixin Yin, Zhongzu Zhang, Hualu Zhao, Zhikui Wu, Junwu Zhang, Jingguo Zhou, Jia Yu, Jia Yu*. A Feedback Loop Consisting of MicroRNA 23a/27a and the Beta-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression. Molecular and Cellular Biology. 2013 Oct.33(20):3994-4007.

     王小爽

     博士，副研究員，碩士生導(dǎo)師

     國家重點研發(fā)計劃“干細(xì)胞專項”青年項目首席科學(xué)家

     2020年度北京市“科技新星”

     E-mail: cattle1131@163.com

個人簡介

王小爽，女，1985年10月出生，博士，副研究員，碩士生導(dǎo)師。2011年7月畢業(yè)于中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2011-2016年于中國科學(xué)院微生物研究所任助理研究員。2016年9月加入中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，醫(yī)學(xué)分子生物學(xué)國家重點實驗室工作。作為負(fù)責(zé)人承擔(dān)科技部重點研發(fā)計劃“干細(xì)胞專項”青年項目，國家自然科學(xué)基金委青年基金、面上項目等，并獲北京市“科技新星”(2020)人才計劃支持。作為第一作者或通訊作者（含共同）在Blood、Nature Communications、J Infect Dis、Theranostics等國際學(xué)術(shù)期刊上發(fā)表SCI論文9篇。目前研究方向為非編碼RNA及RNA結(jié)合蛋白在髓系分化及白血病調(diào)控中的功能機制，以及非編碼RNA加工與成熟的分子機制及其在干細(xì)胞分化與相關(guān)疾病中的功能機理。

在研項目：

1. 1. 科技部國家重點研發(fā)計劃干細(xì)胞與轉(zhuǎn)化研究專項青年項目，2019-2023、RNA結(jié)合蛋白在T淋巴細(xì)胞發(fā)育與再生中的功能和機制研究、首席科學(xué)家。
2. 2. 國家自然科學(xué)基金委面上項目，2020-2023、RNA結(jié)合蛋白QKI5在急性髓系白血病中的轉(zhuǎn)錄調(diào)控功能及機制研究、主持。
3. 3. 北京市科技新星，2020-2023、急性髓系白血病中RNA結(jié)合蛋白的轉(zhuǎn)錄調(diào)控機制及其診療價值研究、主持。

代表性論著 (? first author; * corresponding author):

1. 1.Yue Ren?, Yue Huo?, Weiqian Li?, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. Nuclear fractionation reveals chromatin-enriched RNA-binding proteins and transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14. 22(1):290.
2. 2.Xinjie Bao?, Gengchao Wang?, Shan Yu?, Jian Sun, Hualu Zhao, Yanni Ma, Fang Wang, Xiaoshuang Wang*, Renzhi Wang*, Jia Yu*. Transcriptomic analysis reveals a tumor subtype-mRNA classifier for invasive non-functioning pituitary adenoma diagnostics. Theranostics. 2021 Jan 1. 11(1):132-146.
3. 3.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
4. 4.Hongmei Zhao?, Xiaoshuang Wang?, Ping Yi?, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428.
5. 5.Xiaoshuang Wang?, Xin Fan, Shuai Bi, Ning Li, Beinan Wang*. Toll-like Receptors 2 and 4-Mediated Reciprocal Th17 and Antibody Responses to Group A Streptococcus Infection. J Infect Dis. 2017 Feb 15. 215(4):644-652.
6. 6.Xin Fan?, Xiaoshuang Wang?, Ning Li, Honglian Cui, Baidong Hou, Bin Gao, P. Patrick Cleary*, Beinan Wang*. Sortase A Induces Th17-mediated and Antibody-independent Immunity to Heterologous Serotypes of Group A Streptococci. Plos One.2014 Sep 18. 9(9):e107638.
7. 7.Xiaoshuang Wang?, Jianan Gong?, Jia Yu, Fang Wang, Xinhua Zhang, Xiaolin Yin, Zhenqing Tan, Zimian Luo, Guihua Yang, Chao Shen, Junwu Zhang*. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood. 2012 May 24. 119(21):4992-5004.
8. 8.Fang Wang?, Xiaoshuang Wang?, Guihua Yang?, Pengfei Zhai, Zhen Xiao, Liangyu Xia, Lirong Chen, Yu Wang, Da Gao, Bintao Huang, Jing Wang, Xiaozhong Wang, Laixi Bi, Nian Liu, Yang Yu, Da Gao, Bintao Huang, Jing Wang, Daobin Zhou, Jianan Gong, Hualu Zhao, Xiuhua Bi, Jia Yu, Junwu Zhang*. Down-regulation of miR-29a and miR-142-3p and their diagnostic implication in human acute myeloid leukemia. Mol Bio Rep. 2012 Mar. 39(3):2713-22.
9. 9.Xiaoshuang Wang?, Junwu Zhang*. The microRNAs involved in human myeloid differentiation and myelogenous/myeloblastic leukemia. J Cell Mol Med. 2008 Oct. 12(5A):1445-55. (Review)

     徐嘉悅，博士，助理研究員

     E-mail: xujiayue78@126.com

個人簡介

徐嘉悅，女，1988年7月出生，博士，助理研究員。2016年7月畢業(yè)于中國科學(xué)院北京基因組研究所，理學(xué)博士。2016-2018年于中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，醫(yī)學(xué)分子生物學(xué)國家重點實驗室做博士后。2018-2021年于中國科學(xué)院微生物研究所任助理研究員。2021年7月加入中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，醫(yī)學(xué)分子生物學(xué)國家重點實驗室工作。作為負(fù)責(zé)人承擔(dān)國家自然科學(xué)基金委青年基金項目。作為第一作者（含共同）在Cell Stem Cell、Genome Research、Arthritis & Rheumatology、Nature Communications、Biology Direct等國際學(xué)術(shù)期刊發(fā)表SCI論文7篇。

目前研究方向為利用多組學(xué)手段揭示非編碼RNA在造血發(fā)育中的功能和機制，以及開展血液疾病中的翻譯組學(xué)研究。

在研項目：

國家自然科學(xué)基金委青年基金項目，2020-2022、單細(xì)胞測序技術(shù)解析重要腸道菌對腸道上皮再生與分化的影響、主持。

代表性論著 (? first author; * corresponding author):

1. 1.Beidi Chen?, Xinmiao Jia?, Jiayue Xu?, Lidan Zhao, Junyi J, Bingxuan Wu, Yue Ma, Hao Li , Xiaoxia Zuo, Wenyou Pan, Xiaohan Wang, Shuang Ye, George C. Tsokos *, Jun Wang*, Xuan Zhang*. An Autoimmunoogenic and Proinflammatory Profile Defined by the Gut Microbiota of Patients With Untreated Systemic Lupus Erythematosus. Arthritis & Rheumatology, 2021 Feb. 73(2):232-243.
2. 2.Kai Li?, Jiayue Xu?, Yanyun Luo?, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.
3. 3.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
4. 4.Jie Zhou?, Jiayue Xu?, Lingling Zhang?, Siqi Liu?, Yanni Ma?, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, and Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2):285-298.e5.
5. 5.Linping Wang?, Jiayue Xu?, Huchen Li, Lipu Song, Yi Y, Wensheng Zhang, Guiming Liu*, Chengqiang Feng*. The complete mitochondrial genome of Paecilomyces hepiali (Ascomycota, Eurotiomycetes), MITOCHONDRIAL DNA. 2016. 27(2):916-7.
6. 6.Dapeng Wang*?, Jiayue Xu?, Jun Yu *. KGCAK: a K-mer based database for genome-wild phylogeny and complexity evaluation. Biology Direct. 2015 Sep 16. 10(53):1-2.
7. 7.Jiayue Xu?, Jing Sun?, Jinglong Yin?, Liang Wang, Shan Chi, Cui Liu, Lufeng Ren, Xumin Wang*, Tao Liu*, Shuangxiu Wu*, Jun Yu*. Comparative analysis of four essential Gracilariaceae species in China based on whole transcriptomic sequencing. Acta Oceanologica Sinica. 2014. 33(2):54-62.

     高玉風(fēng)，博士，助理研究員

     E-mail: gaoyufeng@ibms.pumc.edu.cn

個人簡介

高玉風(fēng)，女，1989年11月生，博士，助理研究員。2018年6月畢業(yè)于中國科學(xué)院北京基因組研究所，基因組學(xué)專業(yè)，理學(xué)博士。2018年7月加入中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，醫(yī)學(xué)分子生物學(xué)國家重點實驗室工作。作為負(fù)責(zé)人承擔(dān)國家自然科學(xué)基金委青年基金項目。作為共同第一作者在國際學(xué)術(shù)期刊Blood上發(fā)表研究論文1篇，作為共作者發(fā)表SCI論文2篇。

目前研究方向為利用組學(xué)數(shù)據(jù)和生物信息學(xué)手段描述和刻畫造血干細(xì)胞發(fā)育過程中的分子動態(tài)圖譜，以及疾病中的基因組、轉(zhuǎn)錄組及翻譯組學(xué)研究。

在研項目：

國家自然科學(xué)基金委青年基金項目，2022-2024、腫瘤中異常紅系前體細(xì)胞（EPC）的起源及特征分析、主持。

代表性論著 (? first author; * corresponding author):

1. 1.Xueju Wei?, Yue Huo?, Jingnan Pi?, Yufeng Gao?, Shuan Rao?, Manman He?, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nature Cell Biology. 2022 Aug. 24(8):1278-1290.
2. 2.Yingchi Zhang?, Yufeng Gao?, Hui Zhang?, Jingliao Zhang, Fuhong He, Aleˇs Hn′?zda, Maoxiang Qian, Xiaoming Liu, Yoshihiro Gocho, Ching-Hon Pui, Tao Cheng, Qianfei Wang, Jun J. Yang*, Xiaofan Zhu*, Xin Liu*. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. Blood. 2018 May 17. 131(20):2256-2261.
3. 3.Jingnan Pi?, Wen Wang?, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10):2651-2665.
4. 4.Liu Xin*, Xiumei Hong, Hui-Ju Tsai, Karen K. Mestan, Min Shi, Amira Kefi, Ke Hao, Qi Chen, Guoying Wang, Deanna Caruso, Hua Geng, Yufeng Gao, Jianlin He, Rajesh Kumar, Hongjian Wang, Yunxian Yu, Tami Bartell, Xiao-Di Tan, Robert P. Schleimer, Daniel E. Weeks, Jacqueline A. Pongracic, Xiaobin Wang. Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine. 2018 Mar. 97(9):e0043-e0043.

     王芳

     博士，教授，博士生導(dǎo)師

     國家優(yōu)秀青年科學(xué)基金獲得者

     E-mail: wo_wfang@hotmail.com

個人簡介

王芳，女，1983年2月生，教授，博士生導(dǎo)師。2009年畢業(yè)于北京協(xié)和醫(yī)學(xué)院，獲博士學(xué)位，后留所工作至今。2012年晉升副教授，2017年晉升教授，同年獲聘博士生導(dǎo)師。作為負(fù)責(zé)人承擔(dān)國家自然科學(xué)基金委青年、面上項目，作為科研骨干參與科技部973項目，國家重點研發(fā)計劃。獲科技部重點研發(fā)計劃”青年科學(xué)家項目” (2022)、國家“優(yōu)秀青年科學(xué)基金”（2021）、醫(yī)科院“青年醫(yī)學(xué)人才獎勵項目”（2018）、 “協(xié)和新星” (2016)等人才計劃支持。作為第一作者或通訊作者（含共同）在Nature Cell Biology、Cell Research、Nature Communications、Genome Biology、 Cancer Research、Nucleic Acids Research、Autophagy、Oncogene、JBC等國際學(xué)術(shù)期刊發(fā)表SCI論文20篇。獲教育部自然科學(xué)二等獎（2018）。

目前研究方向為轉(zhuǎn)錄后調(diào)控與造血發(fā)育及血液系統(tǒng)疾病。

在研項目：

1.   科技部國家重點研發(fā)計劃干細(xì)胞專項，2022-2026、造血發(fā)育及再生的翻譯調(diào)控研究、主持。

2.   國家優(yōu)秀青年科學(xué)基金，2021-2023、造血分化調(diào)控、主持。

3.   國家自然科學(xué)基金委面上項目，2020-2023、miRNA初級轉(zhuǎn)錄本作為新型lncRNA調(diào)節(jié)造血紅系分化的功能和機制研究、主持。

代表性論著 (? first author; * corresponding author):

1. 1.Qing You?, Fang Wang?, Rong Du, Jingnan Pi, Huayi Wang, Yue Huo, Jingyi Liu, Chen Wang, Jia Yu*, Yanlian Yang*, Ling Zhu*. m6A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation. Adv Mater. 2022 Dec 9:e2204910.
2. 2.Xueju Wei?, Yue Huo?, Jingnan Pi?, Yufeng Gao?, Shuan Rao?, Manman He?, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nature Cell Biology. 2022 Aug. 24(8):1278-1290.
3. 3.Fang Wang?, Puwen Tan?, Pengcheng Zhang?, Yue Ren?, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7. 8(1):eabg5369.
4. 4.Yue Ren?, Yue Huo?, Weiqian Li?, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. Nuclear fractionation reveals chromatin-enriched RNA-binding proteins and transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14. 22(1):290.
5. 5.Jingnan Pi?, Wen Wang?, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10): 2651-2665.
6. 6.Yan Huang?, Puwen Tan, Xiaoshuang Wang, Ying Yi, Yongfei Hu, Dong Wang, Wang F*. Transcriptomic insights into temporal expression pattern of autophage genes during monocytic and granulocytic differentiation. Autophagy. 2018 Feb 21. 14(3):558-559.
7. 7.Hongmei Zhao?, Xiaoshuang Wang?, Ping Yi?, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428.
8. 8.Fang Wang?, Wei Song?, Hongmei Zhao?, Yanni Ma, Yuxia Li, Di Zhai, JingnanPi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar. 27(3):416-439.
9. 9.Rui Su?, Lei Dong?, Dongling Zou, Hongmei Zhao, Yue Ren, Feng Li, Ping Yi, Lanfang Li, Yong Zhu, Yanni Ma, Jing Wang, Fang Wang*, Jia Yu*. MicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Nov 17. 35(46):6001-6014.
10. 10.Lanfang Li?, Qingya Luo, Zhe Xie, Guiqin Li, Chengyi Mao, Yi Liu, Xin Wen, Na Yin, Jianzhong Cao, Jing Wang, Li Li, Jianhua Yu, Fang Wang*, Ping Yi*. Characterization of the expression of the RNA binding protein eIF4G1 and its clinicopathological correlation with serous ovarian cancer. PLoS One. 2016 Sep 26. 11(9):e0163447.
11. 11.Peng-Fei Zhai?, Fang Wang?, Rui Su, Hai-Shuang Lin, Chong-Liang Jiang, Gui-Hua Yang, Jia Yu, Jun-Wu Zhang*. The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis. J Biol Chem. 2014 Aug 15. 289(33):22600-13.
12. 12.Yuxia Li, Hua Bai, Zhongzu Zhang, Weihua Li, Lei Dong, Xueju Wei, Yanni Ma, Junwu Zhang, Jia Yu, Guotao Sun*, Fang Wang*. The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2. Mol. Cells. 2014 Mar. 37(3):1-7.
13. 13.Fang Wang?, Yong Zhu?, Lihua Guo?, Lei Dong, Huiwen Liu, Haixin Yin, Zhongzu Zhang, Yuxia Li, Changzheng Liu, Yanni Ma, Wei Song, Aibin He, Qiang Wang, Linfang Wang, Junwu Zhang, Jianxiong Li, Jia Yu*. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Research. 2014 Jan. 42(1):442-57.
14. 14.Yong Zhu?, Dongsheng Wang?, Fang Wang?, Tingting Li, Lei Dong, Huiwen Liu, Yanni Ma, Fengbing Jiang, Haixin Yin, Wenting Yan, Ming Luo, Z Tang, Guoyuan Zhang, Qiang Wang, Junwu Zhang, Jingguo Zhou, Jia Yu*. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Research. 2013 Apr. 41(7):4129-43.
15. 15.Fang Wang?, Xiao-Shuang Wang, Gui-Hua Yang, Peng-Fei Zhai, Peng-Fei Zhai, Zhen Xiao, Liang-Yu Xia, Li-Rong Chen, Yu Wang, Xiao-Zhong Wang, Lai-Xi Bi, Nian Liu, Yang Yu, Da Gao, Bin-Tao Huang, Jing Wang, Dao-Bin Zhou, Jia-Nan Gong, Hua-Lu Zhao, Xiu-Hua Bi, Jia Yu, Jun-Wu Zhang*. miR-29a and miR-142-3p downregulation and diagnostic implication in human acute myeloid leukemia. Mol Biol Rep. 2012 Mar. 39(3):2713-22.
16. 16.Fang Wang?, Jia Yu, Guihua Yang, Xiaoshuang Wang, Junwu Zhang*. Regulation of erythroid differentiation by miR-376a and its targets. Cell Research. 2011 Aug. 21(8): 1196-209.
17. 17.Jin-Yun Yuan?, Fang Wang?, Jia Yu?, Gui-Hua Yang,Xiao-Ling Liu, Jun-Wu Zhang*. MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells. J. Cell. Mol. Med. Nov-Dec 2009. 13(11-12):4551-9.
18. 18.Jia Yu?, Fang Wang?, Gui-Hua Yang, Fan-Long Wang, Yan-Ni Ma, Zhan-Wen Du, Jun-Wu Zhang*. Human miRNA Clusters: genomic organization and expression profile in leukemia cell lines. Biochem Biophy Res Commun. 2006 Oct 13. 349(1):59-68.