本課題組由張俊武研究員建立于1993年，承擔過(guò)國家七.五、863、基礎研究重大前期專(zhuān)項、973、重大科學(xué)計劃、美國中華醫學(xué)基金（CMB）、國家自然科學(xué)基金重大項目和面上項目等，在1990-2010近二十年間重點(diǎn)研究珠蛋白基因表達調控、造血相關(guān)基因功能及機制及老年性癡呆（AD）相關(guān)基因，已畢業(yè)博士33人，碩士6人。共發(fā)表論文130多篇（SCI 44篇）。2012年，余佳研究員接任課題組長(cháng)，聚焦“RNA和干細胞生物學(xué)”，重點(diǎn)關(guān)注RNA和遺傳信息傳遞如何影響干細胞命運決定、造血譜系分化及相關(guān)疾病，以期為人類(lèi)疾病的細胞治療、靶向治療及成分輸血提供理論基礎和新方向。通過(guò)近十年努力，課題組建立了成熟的干細胞培養及移植平臺、RNA實(shí)驗平臺、組學(xué)及計算平臺；培養了一批科研骨干及生物信息學(xué)團隊；并與國內外多個(gè)領(lǐng)域內一流實(shí)驗室建立了緊密合作關(guān)系、共享研究資源、共同培養研究生與博士后。現有工作人員包括：余佳（教授）、 張俊武（研究員）、王芳（教授）、馬艷妮（研究員）、王小爽（副研究員）、趙華路（副主任技師）、徐嘉悅（助理研究員）、高玉風(fēng)（助理研究員）、司艷敏（技術(shù)員）、果月紅（技術(shù)員）、博士后4人（劉思琪、李衛倩、何家驩、孫晨光），在讀博士研究生11人，碩士研究生10人。課題組既有豐富的歷史沉淀，又年輕而朝氣蓬勃，學(xué)術(shù)氣氛積極向上，致力于成為“嚴謹、求實(shí)、快樂(lè )、奮進(jìn)”的研究團隊。歡迎各位有志于科學(xué)研究、對干細胞及RNA生物學(xué)感興趣的考生報考。

     余佳，博士，長(cháng)聘教授（長(cháng)準聘系列），研究員，課題組長(cháng)

     國家杰出青年科學(xué)基金獲得者

     醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室

     中國醫學(xué)科學(xué)院基礎醫學(xué)研究所&北京協(xié)和醫學(xué)院基礎學(xué)院

     E-mail: j-yu@ibms.pumc.edu.cn; yujia_new@msn.com

個(gè)人簡(jiǎn)介

余佳，男，1978年生，研究員，博士生導師，北京協(xié)和醫學(xué)院長(cháng)聘教授（首批）、RNA與干細胞生物學(xué)課題組組長(cháng)，中國醫學(xué)科學(xué)院RNA與造血調控研究重點(diǎn)實(shí)驗室主任，醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室PI。獲得國家杰出青年科學(xué)基金(2017，生命科學(xué)部)，長(cháng)江學(xué)者獎勵計劃(2017)，百千萬(wàn)人才工程國家級人選（2019），國務(wù)院政府特殊津貼（2020）等人才項目支持。擔任科技部十三五“發(fā)育編程及其代謝調節”重點(diǎn)研發(fā)專(zhuān)項首席科學(xué)家，十四五“發(fā)育編程及其代謝調節”重點(diǎn)研發(fā)專(zhuān)項總體專(zhuān)家組、指南編寫(xiě)組成員。2006年7月畢業(yè)于中國醫學(xué)科學(xué)院/北京協(xié)和醫學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2006-2007年在美國伊利諾伊大學(xué)芝加哥分校工作(Post-doc)。2007-2009年在美國西北大學(xué)Feinberg醫學(xué)院工作(Post-doc)。2009年10月回國加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化系及醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室。作為負責人承擔國家自然科學(xué)基金委重大研究計劃、重點(diǎn)項目及面上項目等；作為負責人承擔科技部國家重點(diǎn)研發(fā)計劃、973子課題及國家重大研究計劃。余佳博士同時(shí)擔任中國醫學(xué)科學(xué)院-以色列Weizmann研究所聯(lián)合實(shí)驗室PI，中國醫學(xué)科學(xué)院“醫學(xué)與健康科技創(chuàng )新工程”創(chuàng )新團隊項目首席科學(xué)家，人血細胞分子圖譜（ABC）研究聯(lián)盟首批倡議及參加成員。余佳實(shí)驗室主要興趣集中在造血調控、干細胞命運及轉化醫學(xué)，綜合運用多種組學(xué)及計算生物學(xué)方法，干細胞培養及基因操縱等體外實(shí)驗技術(shù)，干細胞移植、基因敲除小鼠及譜系示蹤等體內技術(shù)，結合生化與分子生物學(xué)手段，研究RNA、互作蛋白質(zhì)及相關(guān)遺傳信息傳遞過(guò)程在干細胞或疾病中的功能和調控機理。在組織器官發(fā)育與疾病的細胞圖譜、非編碼RNA生成與加工新機理、干細胞命運調控新機制等方面取得突出成果，相關(guān)研究成果作為通訊作者（含共同）在Cell Stem Cell、Developmental Cell、Blood、Cell Research、Science Advances、EMBO Journal（2015，2021）、Genome Research、Nature Communications（2017，2019）、Genome Biology 、Cancer Research（2010，2015，2020）、Nucleic Acids Research（2013，2014，2017，2020）、Autophagy、Oncogene、MCB等國際主流學(xué)術(shù)期刊上發(fā)表SCI論文30余篇，被引用4000余次。獲教育部自然科學(xué)二等獎（2018）。現擔任中國生理學(xué)會(huì )血液生理專(zhuān)業(yè)委員會(huì )理事，中國細胞生物學(xué)會(huì )干細胞專(zhuān)業(yè)委員會(huì )理事， 北京市生化協(xié)會(huì )理事。擔任Blood, Nature Communications, Nucleic Acids Research, Oncogene, Cancer Research, MCB, JBC等雜志特邀審稿人。

研究方向 

RNA與干細胞生物學(xué)

研究工作簡(jiǎn)介

              RNA生物學(xué)是系統認識和研究各種RNA的生物發(fā)生、分子特征、生物學(xué)功能和分子機理的一門(mén)學(xué)科，也是生命科學(xué)領(lǐng)域的新興學(xué)科。過(guò)去二十年里，這一學(xué)科得到長(cháng)足發(fā)展，特別是高通量測序技術(shù)的出現不但幫助發(fā)現了更多編碼RNA的特征，而且鑒定了多種非編碼RNA分子，是目前國際上最前沿的領(lǐng)域之一。干細胞生物學(xué)也是目前國際上最前沿和挑戰最大的領(lǐng)域之一。闡明干細胞自我更新和分化的調控機理可為再生醫學(xué)和癌癥治療提供重要支撐。以RNA為切入點(diǎn)研究干細胞生物學(xué)具有獨特優(yōu)勢：i. 以往被視為遺傳信息傳遞中間站的messenger RNA (mRNA)其實(shí)具有遠超我們所理解的轉錄后調控方式，如RNA編輯、RNA修飾、RNA穩定性調節、RNA選擇性剪接及RNA選擇性加帽或加尾等，這些方式均會(huì )引起相應的基因表達變化，從而最終改變遺傳信息從DNA向蛋白質(zhì)的共線(xiàn)性傳遞。近期關(guān)于RNA修飾的研究已經(jīng)衍生出RNA表觀(guān)遺傳學(xué)這一學(xué)科方向，也誕生了表觀(guān)轉錄組（Epitranscriptome）概念；ii. RNA組學(xué)，特別是單細胞RNA組學(xué)的發(fā)展，使我們可以精確描繪發(fā)育層級的分子動(dòng)力學(xué)圖譜，從而推動(dòng)了目前中國、美國及歐洲的人類(lèi)細胞圖譜計劃；iii. ENCODE計劃最重要的貢獻之一：非編碼RNA的大量發(fā)現，更是大大擴充了人類(lèi)對于自身，乃至各個(gè)物種基本遺傳和進(jìn)化的認知。但該計劃也提出了未來(lái)多個(gè)重要的挑戰，即各種各樣的非編碼RNA的分子特征是什么，是否具有重要的生物學(xué)功能，有什么獨特的分子調控機制，在轉化醫學(xué)中是否有應用價(jià)值？

課題組主攻下列科學(xué)問(wèn)題：

1、造血干細胞起源、異質(zhì)性、譜系分化與生態(tài)的分子動(dòng)力學(xué)圖譜；

2、非編碼RNA加工與成熟的分子機制及其在干細胞分化與相關(guān)疾病中的作用機理；

3、胚胎及成體干細胞功能的RNA調控機理；

4、RNA代謝及調控的生理功能和轉化醫學(xué)應用。 

代表性研究成果簡(jiǎn)介

一、細胞與生態(tài)圖譜

1. 1. 利用深度RNA-sequencing結合全基因組DNA-sequencing繪制出造血譜系RNA編輯圖譜，發(fā)現調控造血干細胞分化的關(guān)鍵編輯基因及其入核后的轉錄調控機理（Blood, 2021）；[被選為封面文章，USCD教授Catriona Jamieson 在Blood同期進(jìn)行述評：Commentary: Upping the Antizyme: AZIN1 Directs Stem Cell Fate]
2. 2. 利用深度RNA-sequencing繪制出精子發(fā)育全程的lncRNA圖譜，鑒定功能性lncRNA及其轉錄調控機理（Genome Research, 2020）;
3. 3. 利用深度RNA-sequencing繪制出人垂體瘤轉錄組圖譜，結合外泌體分離與機器學(xué)習獲得首個(gè)侵襲性垂體瘤血液診斷panel并申請中國專(zhuān)利（Theranostics, 2020）;
4. 4. 利用單細胞測序技術(shù)繪制出造血干細胞發(fā)育全程的lncRNA及RNA剪接圖譜，揭示調控“內皮-造血”轉換的關(guān)鍵lncRNA及RNA可變剪接事件（Cell Stem Cell, 2019； Science Advances 2022），[其中Cell Stem Cell文章被Faculty 1000推薦為必讀文章]；
5. 5. 利用RNA-sequencing繪制出造血干細胞向粒系/單核系分化命運選擇中的自噬分子圖譜（Autophagy, 2018）；
6. 6. 利用單細胞測序技術(shù)繪制出造血干細胞發(fā)育全程自噬分子圖譜（Autophagy, 2017）。

二、非編碼RNA生成、加工、成熟及功能

1. 1. 通過(guò)系統性調查假基因的表達特征及與疾病的關(guān)聯(lián)，發(fā)現假基因來(lái)源非編碼RNA-HBBP1演化出調控人紅細胞發(fā)育及疾病的重要作用及全新機制 （Developmental Cell, 2021）; [ISEH(國際實(shí)驗血液學(xué)會(huì ))官方雜志Experimental Hematology特邀余佳和馬艷妮教授撰寫(xiě)領(lǐng)域展望：Perspective: Pseudogenes and their potential functions in hematopoiesis]
2. 2. 揭示腫瘤進(jìn)程中部分microRNA存在雙臂表達的“arm imbalance”現象，發(fā)現“靶基因RNA引導的microRNA降解”可部分解釋其發(fā)生機制，提出靶向“microRNA雙臂”的腫瘤治療新策略（Nature Communications, 2019）;
3. 3. 解決了自microRNA發(fā)現以來(lái)的一個(gè)重要科學(xué)問(wèn)題即microRNA初級轉錄本莖環(huán)結構遠端序列是否具有調節功能？證明莖環(huán)遠端序列存在RNA順式作用元件，并且這些RNA順式作用元件可通過(guò)蛋白-RNA互作及其所介導RNA高級結構參與microRNA加工（Cell Research, 2017）；
4. 4. 揭示一個(gè)或多個(gè)RNA順式作用元件通過(guò)蛋白-RNA互作及其所介導的RNA高級結構參與microRNA加工，并調控造血干細胞分化 （Nature Communications, 2017）；
5. 5. 建立蛋白質(zhì)-RNA互作事件數據庫Raid 2.0 （Nucleic Acids Research, 2017）。

三、 干細胞命運調控

1. 1. 系統性揭示染色質(zhì)結合型RNA結合蛋白（Che-RBP）在造血干細胞分化中的蛋白質(zhì)/DNA及蛋白質(zhì)/RNA結合規律，發(fā)現Che-RBP QKI-5通過(guò)調控DNA轉錄促進(jìn)單核細胞分化（Genome Biology. 2021）;
2. 2. 系統性揭示了RNA結合蛋白在胚胎干細胞多能性退出中的作用，發(fā)現hnRNPLL通過(guò)調控mRNA可變剪接促進(jìn)胚胎干細胞退出多能性（The EMBO J. 2021）;
3. 3. 鑒定胚胎干細胞定向中胚層分化的關(guān)鍵microRNA基因簇并發(fā)現其“表型冗余”現象和產(chǎn)生機理 (The EMBO J. 2015)。

四、RNA代謝的生理功能和轉化醫學(xué)應用

1. 1. 發(fā)現RNA結合蛋白介導的RNA修飾參與腫瘤發(fā)生，是腫瘤治療的新靶標（Cancer Research, 2021; Nucleic Acids Research, 2020）；
2. 2. 鑒定了多個(gè)實(shí)體腫瘤發(fā)生發(fā)展相關(guān)的microRNA并闡明其致癌機理及轉化潛力  (Cancer Research, 2010, 2015; Carcinogenesis, 2014; Journal of Hepatology, 2010)；
3. 3. 鑒定了成體造血干細胞向髓系分化的關(guān)鍵microRNA基因/基因簇 (Blood, 2012；Cell Death&Differentiation, 2014)；
4. 4. 揭示microRNA與紅系分化關(guān)鍵轉錄因子間的多重互作機制 (Nucleic Acids Research, 2013, 2014; Mol. Cel. Biol, 2013)；發(fā)現RISC復合物成員Ago2介導的microRNA間"cross talk"是紅系分化的重要分子事件(Cell Research, 2011)；
5. 5. 鑒定了多個(gè)可用于急性髓系白血病診治的microRNA靶標(Oncogene, 2015, 2016; PLoS Genetics, 2016)。

在研項目：

1. 1. 科技部國家重點(diǎn)研發(fā)計劃發(fā)育與代謝專(zhuān)項，2019-2024、造血穩態(tài)的代謝調控機理、首席科學(xué)家。
2. 2. 國家杰出青年科學(xué)基金，2018-2022、造血細胞發(fā)育調控、主持。

代表性論著(zhù) (? first author; * corresponding author):

1. 1.Qing You?, Fang Wang?, Rong Du, Jingnan Pi, Huayi Wang, Yue Huo, Jingyi Liu, Chen Wang, Jia Yu*, Yanlian Yang*, Ling Zhu*. m6A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation. Adv Mater. 2022 Dec 9:e2204910.
2. 2.Hongwei Chen? , Xin Wen? , Shanshan Liu? , Tian Sun , Hua Song , Fang Wang , Jiayue Xu, Yueyang Zhang, Yuanjin Zhao, Jia Yu* , Lingyun Sun*. Dissecting Heterogeneity Reveals a Unique BAMBIhigh MFGE8high Subpopulation of Human UC-MSCs. Adv Sci (Weinh). 2022 Nov 14. 10(1):e2202510.
3. 3.Xueju Wei?, Yue Huo?, Jingnan Pi?, Yufeng Gao?, Shuan Rao?, Manman He?, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nature Cell Biology. 2022 Aug. 24(8):1278-1290.
4. 4.Fang Wang?, Puwen Tan?, Pengcheng Zhang?, Yue Ren?, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7;8(1):eabg5369.
5. 5.Yanni Ma?*, Zhongyang Chen, Jia Yu*. Pseudogenes and their potential functions in hematopoiesis. Experimental Hematology. 2021 Nov. 103:24-29.
6. 6.Fengjiao Wang?, Jiahuan He?, Siqi Liu?, Ai Gao, Liu Yang, Guohuan Sun, Wanqiu Ding, Chuanyun Li, Fanglin Gou, Manman He, Fang Wang, Xiaoshuang Wang, Xiangnan Zhao, Ping Zhu, Shao Hao, Yanni Ma*, Hui Cheng*, Jia Yu*, Tao Cheng*. A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021 Nov 18. 138(20):1939-1952.
7. 7.Yue Ren?, Yue Huo?, Weiqian Li?, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14 22(1).290.
8. 8.Jingnan Pi?, Wen Wang?, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10): 2651-2665.
9. 9.Yanni Ma?*, Siqi Liu?, Jie Gao?, Chunyan Chen?, Xin Zhang?, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Feb 22. 56(4):478-493.e11.
10. 10.Xue Wang?, Changyun Ping?, Puwen Tan?, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729.
11. 11.Kai Li?, Jiayue Xu?, Yanyun Luo?, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.
12. 12.Xinjie Bao?, Gengchao Wang?, Shan Yu?, Jian Sun, Hualu Zhao, Yanni Ma, Fang Wang, Xiaoshuang Wang*, Renzhi Wang*, Jia Yu*. Transcriptomic analysis reveals a tumor subtype-mRNA classifier for invasive non-functioning pituitary adenoma diagnostics. Theranostics. 2021 Jan 1. 11(1):132-146.
13. 13.Tao Liu?, Qinglv Wei?, Jing Jin?, Qingya Luo, Yi Liu, Yu Yang, Chunming Cheng, Lanfang Li, Jingnan Pi, Yanmin Si, Hualiang Xiao, Li Li, Shuan Rao, Fang Wang, Jianhua Yu, Jia Yu*, Dongling Zou*, Ping Yi*. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic Acids Research. 2020 Apr 17. 48(7):3816-3831.
14. 14.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
15. 15.Jie Zhou?, Jiayue Xu?, Lingling Zhang?, Siqi Liu?, Yanni Ma?, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2): 285-298.e5.
16. 16.Lintao Zhao?, Ran He?, Haixia Long?, Bo Guo?, Qingzhu Jia, Diyuan Qin, Si-Qi Liu, Zhongyu Wang, Tong Xiang, Jue Zhang, Yulong Tan, Jiani Huang, Junying Chen, Fang Wang, Minglu Xiao, Jianbao Gao, Xinxin Yang, Hao Zeng, Xinxin Wang, Chunyan Hu, Peter B. Alexander, Alistair L. J. Symonds, Jia Yu, Yisong Wan, Qi-Jing Li*, Lilin Ye*, Bo Zhu*. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nature Medicine. 2018 Oct. 24(10):1536–1544.
17. 17.Weiqian Li?, Yue Ren, Yanmin Si, Fang Wang*, Jia Yu*. Long non-coding RNAs in hematopoietic regulation. Cell Regen (London). 2018 Oct 11. 7(2):27-32. (Review)
18. 18.Hongmei Zhao?, Xiaoshuang Wang?, Ping Yi?, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428.
19. 19.Yongfei Hu?, Yan Huang, Ying Yi, Hongwei Wang, Bing Liu*, Jia Yu*, Dong Wang*. Single-cell RNA sequencing highlights transcription activity of autophagy-related genes during hematopoietic stem cell formation in mouse embryos. Autophagy. 2017 Apr 3. 13(4):770-771.
20. 20.Fang Wang?, Wei Song?, Hongmei Zhao?, Yanni Ma, Yuxia Li, Di Zhai, JingnanPi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar. 27(3):416-439.
21. 21.Ying Yi?, Yue Zhao, Chunhua Li, Lin Zhang, Huiying Huang, Yana Li, LanlanLiu, Ping Hou, Tianyu Cui, Puwen Tan, Yongfei Hu, Ting Zhang, Yan Huang, Xiaobo Li*, Jia Yu*, Dong Wang*. RAID v2.0: an updated resource of RNA-associated interactions across organisms. Nucleic Acids Research. 2017 Jan 4. 45(D1):D115-D118.
22. 22.Rui Su?, Lei Dong?, Dongling Zou, Hongmei Zhao, Yue Ren, Feng Li, Ping Yi, Lanfang Li, Yong Zhu, Yanni Ma, Jing Wang, Fang Wang*, Jia Yu*. MicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Nov 17. 35(46):6001-6014.
23. 23.Yanni Ma?, Nan Yao?, Guang Liu?, Lei Dong, Fang Wang, Bin Wang, He Dong, Xueju Wei, Meili Zhang, Shaowei Ji, Yufang Liu, Junwu Zhang, Yangming Wang, Yue Huang*, Jia Yu*. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cell. The EMBO Journal. 2015 Feb 3. 34(3):361–378.
24. 24.Jianan Gong?, Jianxiong Li, Yi Wang, Changzhegn Liu, Hongyan Jia, Chongliang Jiang, Yuxuan Wang, Min Luo, Hongmei Zhao, Lei Dong, Wei Song, Fang Wang, Weibin Wang, Junwu Zhang*, Jia Yu*. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis. 2014 Feb. 35(2):497-506.
25. 25.Fang Wang?, Yong Zhu?, Lihua Guo?, Lei Dong, Huiwen Liu, Haixin Yin, Zhongzu Zhang, Y Li, Changzheng Liu, Yanni Ma, Wei Song, Aibin He, Qiang Wang, Linfang Wang, Junwu Zhang, Jianxiong Li, Jia Yu*. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Research. 2014 Jan. 42(1):442-457.
26. 26.Yanni Ma?, Bin Wang?, Fengbing Jiang?, Dongsheng Wang?, Huiwen Liu, Yunmeng Yan, He Dong, Fang Wang, Bei Gong, Yong Zhu, Lei Dong, Haixin Yin, Zhongzu Zhang, Hualu Zhao, Zhikui Wu, Junwu Zhang, Jingguo Zhou, Jia Yu, Jia Yu*. A Feedback Loop Consisting of MicroRNA 23a/27a and the Beta-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression. Molecular and Cellular Biology. 2013 Oct. 33(20):3994-4007.
27. 27.Yong Zhu?, Dongsheng Wang?, Fang Wang?, Tingting Li, Lei Dong, Huiwen Liu, Yanni Ma, Fengbing Jiang, Haixin Yin, Wenting Yan, Ming Luo, Z Tang, Guoyuan Zhang, Qiang Wang, Junwu Zhang, Jingguo Zhou, Jia Yu*. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Research. 2013 Apr. 41(7):4129-43.
28. 28.Jia Yu*, Fang Wang. Recent progress in microRNA study: Benefits from technique advance. SCIENCE CHINA Life Sciences. 2012 July. 55(7):649-50. (Invited comment)
29. 29.Xiaoshuang Wang?, Jianan Gong?, Jia Yu, Fang Wang, Xinhua Zhang, Xiaolin Yin, Zhenqing Tan, Zimian Luo, Guihua Yang, Chao Shen, Junwu Zhang. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood. 2012 May 24. 119(21):4992-5004.
30. 30.Fang Wang?, Jia Yu, Guihua Yang, Xiaoshuang Wang, Junwu Zhang*. Regulation of erythroid differentiation by miR-376a and its targets. Cell Research. 2011 Aug. 21(8):1196-209.
31. 31.Jia Yu?, Han Peng?, Qing Ruan, Anees Fatima, Spiro Getsios, and Robert M. Lavker. MicroRNA-205 promotes keratinocyte migration via the lipidphosphatase SHIP2. The FASEB Journal. 2010 Oct. 24(10):3950-9.
32. 32.Shuangni Yu?, Zhaohui Lu, Changzheng Liu, Yunxiao Meng, Yihui Ma, Wugan Zhao, Jianping Liu, Jia Yu*, Jie Chen*. MiRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Research. 2010 Jul 15. 70(14):6015-25.
33. 33.Changzheng Liu?, Jia Yu?, Shuangni Yu, Robert M.Lavker, Lei Cai, Wei Liu, Kegong Yang, Xiaodong He, Songsen Chen. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. Journal of Hepatology. 2010 Jul. 53(1):98-107. (Cover story)
34. 34.Robert M. Lavker?*, Jia Yu and David G Ryan. The Tiny World of MicroRNAsin the Cross Hairs of the Mammalian Eye. Human Genomics. 2009 Jul. 3(4):332-348. (Review)
35. 35.Jia Yu?, David G. Ryan?, Spiro Getsios, Michelle Oliveira-Fernandes, Anees Fatima, and Robert M. Lavker. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proceedings of the National Academy of Sciences of the USA. 2008 Dec 9. 105(49):19300-5.

     馬艷妮

     博士，助理教授（長(cháng)準聘系列），研究員，博士生導師

     國家優(yōu)秀青年科學(xué)基金獲得者

     2015年度院校“協(xié)和新星”，2017年度北京市“科技新星”

     E-mail: yanni_ma@126.com，mayanni@ibms.cams.cn

個(gè)人簡(jiǎn)介

馬艷妮，女，1981年11月出生，北京協(xié)和醫學(xué)院準聘助理教授，研究員，博士生導師。2008年7月畢業(yè)于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2008-2011年于中國科學(xué)院生物物理研究所任助理研究員。2011年7月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室工作。作為負責人承擔國家自然科學(xué)基金委面上、青年項目，作為科研骨干參與科技部973項目、國家重點(diǎn)研發(fā)計劃。獲國家“優(yōu)秀青年科學(xué)基金”（2022）、北京市“科技新星”(2017)、醫科院“青年醫學(xué)人才獎勵項目”（2018）、 “協(xié)和新星” (2015)等人才計劃支持。作為第一作者或通訊作者（含共同）在Cell Stem Cell、Developmental Cell、Blood、EMBO J（2015，2021）、Genome Research、Nature Communications、Mol Cell Bio等國際學(xué)術(shù)期刊發(fā)表SCI論文14篇。

目前研究方向為RNA代謝在多能干細胞、造血干細胞功能維持及分化中的調控機制研究。

在研項目：

1. 1. 科技部國家重點(diǎn)研發(fā)計劃發(fā)育與代謝專(zhuān)項，2019-2024、獲得性性狀通過(guò)母系傳遞的表觀(guān)遺傳機制、科研骨干。
2. 2. 國家優(yōu)秀青年科學(xué)基金，2022-2024、RNA與造血調控、主持。
3. 3. 國家自然科學(xué)基金委面上項目，2020-2023、hnRNPLL調控造血干細胞發(fā)育及多能性維持的功能和機制研究、主持。
4. 4. 國家自然科學(xué)基金委面上項目，2018-2021、長(cháng)非編碼RNA BGLT3激活胎兒期血紅蛋白的功能及機制研究、主持。

代表性論著(zhù) (? first author; * corresponding author):

1. 1.Yanni Ma?*, Zhongyang Chen, Jia Yu*. Pseudogenes and their potential functions in hematopoiesis. Experimental Hematology. 2021 Nov. 103:24-29.
2. 2.Fengjiao Wang?, Jiahuan He?, Siqi Liu?, Ai Gao, Liu Yang, Guohuan Sun, Wanqiu Ding, Chuanyun Li, Fanglin Gou, Manman He, Fang Wang, Xiaoshuang Wang, Xiangnan Zhao, Ping Zhu, Shao Hao, Yanni Ma*, Hui Cheng*, Jia Yu*, Tao Cheng*. Comprehensive RNA editome reveals edited Azin1 as a novel DDX1 partner to facilitate hematopoietic stem cell differentiation. Blood. 2021 Nov 18. 138(20):1939-1952.
3. 3.Yanni Ma?*, Siqi Liu?, Jie Gao?, Chunyan Chen?, Xin Zhang?, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Feb 22. 56(4):478-493.e11.56(4):478–493.e11.
4. 4.Xue Wang?, Changyun Ping?, Puwen Tan?, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729.
5. 5.Kai Li?, Jiayue Xu?, Yanyun Luo?, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.
6. 6.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
7. 7.Jie Zhou?, Jiayue Xu?, Lingling Zhang?, Siqi Liu?, Yanni Ma?, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2):285-298.e5.
8. 8.Yanni Ma?, Nan Yao?, Guang Liu?, Lei Dong, Fang Wang, Bin Wang, He Dong, Xueju Wei, Meili Zhang, Shaowei Ji, Yufang Liu, Junwu Zhang, Yangming Wang, Yue Huang*, Jia Yu*. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cell. The EMBO Journal. 2015 Feb 3. 34(3):361–378.
9. 9.Yanni Ma?, Bin Wang?, Fengbing Jiang?, Dongsheng Wang?, Huiwen Liu, Yunmeng Yan, He Dong, Fang Wang, Bei Gong, Yong Zhu, Lei Dong, Haixin Yin, Zhongzu Zhang, Hualu Zhao, Zhikui Wu, Junwu Zhang, Jingguo Zhou, Jia Yu, Jia Yu*. A Feedback Loop Consisting of MicroRNA 23a/27a and the Beta-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression. Molecular and Cellular Biology. 2013 Oct.33(20):3994-4007.

     王小爽

     博士，副研究員，碩士生導師

     國家重點(diǎn)研發(fā)計劃“干細胞專(zhuān)項”青年項目首席科學(xué)家

     2020年度北京市“科技新星”

     E-mail: cattle1131@163.com

個(gè)人簡(jiǎn)介

王小爽，女，1985年10月出生，博士，副研究員，碩士生導師。2011年7月畢業(yè)于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2011-2016年于中國科學(xué)院微生物研究所任助理研究員。2016年9月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室工作。作為負責人承擔科技部重點(diǎn)研發(fā)計劃“干細胞專(zhuān)項”青年項目，國家自然科學(xué)基金委青年基金、面上項目等，并獲北京市“科技新星”(2020)人才計劃支持。作為第一作者或通訊作者（含共同）在Blood、Nature Communications、J Infect Dis、Theranostics等國際學(xué)術(shù)期刊上發(fā)表SCI論文9篇。目前研究方向為非編碼RNA及RNA結合蛋白在髓系分化及白血病調控中的功能機制，以及非編碼RNA加工與成熟的分子機制及其在干細胞分化與相關(guān)疾病中的功能機理。

在研項目：

1. 1. 科技部國家重點(diǎn)研發(fā)計劃干細胞與轉化研究專(zhuān)項青年項目，2019-2023、RNA結合蛋白在T淋巴細胞發(fā)育與再生中的功能和機制研究、首席科學(xué)家。
2. 2. 國家自然科學(xué)基金委面上項目，2020-2023、RNA結合蛋白QKI5在急性髓系白血病中的轉錄調控功能及機制研究、主持。
3. 3. 北京市科技新星，2020-2023、急性髓系白血病中RNA結合蛋白的轉錄調控機制及其診療價(jià)值研究、主持。

代表性論著(zhù) (? first author; * corresponding author):

1. 1.Yue Ren?, Yue Huo?, Weiqian Li?, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. Nuclear fractionation reveals chromatin-enriched RNA-binding proteins and transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14. 22(1):290.
2. 2.Xinjie Bao?, Gengchao Wang?, Shan Yu?, Jian Sun, Hualu Zhao, Yanni Ma, Fang Wang, Xiaoshuang Wang*, Renzhi Wang*, Jia Yu*. Transcriptomic analysis reveals a tumor subtype-mRNA classifier for invasive non-functioning pituitary adenoma diagnostics. Theranostics. 2021 Jan 1. 11(1):132-146.
3. 3.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
4. 4.Hongmei Zhao?, Xiaoshuang Wang?, Ping Yi?, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428.
5. 5.Xiaoshuang Wang?, Xin Fan, Shuai Bi, Ning Li, Beinan Wang*. Toll-like Receptors 2 and 4-Mediated Reciprocal Th17 and Antibody Responses to Group A Streptococcus Infection. J Infect Dis. 2017 Feb 15. 215(4):644-652.
6. 6.Xin Fan?, Xiaoshuang Wang?, Ning Li, Honglian Cui, Baidong Hou, Bin Gao, P. Patrick Cleary*, Beinan Wang*. Sortase A Induces Th17-mediated and Antibody-independent Immunity to Heterologous Serotypes of Group A Streptococci. Plos One.2014 Sep 18. 9(9):e107638.
7. 7.Xiaoshuang Wang?, Jianan Gong?, Jia Yu, Fang Wang, Xinhua Zhang, Xiaolin Yin, Zhenqing Tan, Zimian Luo, Guihua Yang, Chao Shen, Junwu Zhang*. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood. 2012 May 24. 119(21):4992-5004.
8. 8.Fang Wang?, Xiaoshuang Wang?, Guihua Yang?, Pengfei Zhai, Zhen Xiao, Liangyu Xia, Lirong Chen, Yu Wang, Da Gao, Bintao Huang, Jing Wang, Xiaozhong Wang, Laixi Bi, Nian Liu, Yang Yu, Da Gao, Bintao Huang, Jing Wang, Daobin Zhou, Jianan Gong, Hualu Zhao, Xiuhua Bi, Jia Yu, Junwu Zhang*. Down-regulation of miR-29a and miR-142-3p and their diagnostic implication in human acute myeloid leukemia. Mol Bio Rep. 2012 Mar. 39(3):2713-22.
9. 9.Xiaoshuang Wang?, Junwu Zhang*. The microRNAs involved in human myeloid differentiation and myelogenous/myeloblastic leukemia. J Cell Mol Med. 2008 Oct. 12(5A):1445-55. (Review)

     徐嘉悅，博士，助理研究員

     E-mail: xujiayue78@126.com

個(gè)人簡(jiǎn)介

徐嘉悅，女，1988年7月出生，博士，助理研究員。2016年7月畢業(yè)于中國科學(xué)院北京基因組研究所，理學(xué)博士。2016-2018年于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室做博士后。2018-2021年于中國科學(xué)院微生物研究所任助理研究員。2021年7月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室工作。作為負責人承擔國家自然科學(xué)基金委青年基金項目。作為第一作者（含共同）在Cell Stem Cell、Genome Research、Arthritis & Rheumatology、Nature Communications、Biology Direct等國際學(xué)術(shù)期刊發(fā)表SCI論文7篇。

目前研究方向為利用多組學(xué)手段揭示非編碼RNA在造血發(fā)育中的功能和機制，以及開(kāi)展血液疾病中的翻譯組學(xué)研究。

在研項目：

國家自然科學(xué)基金委青年基金項目，2020-2022、單細胞測序技術(shù)解析重要腸道菌對腸道上皮再生與分化的影響、主持。

代表性論著(zhù) (? first author; * corresponding author):

1. 1.Beidi Chen?, Xinmiao Jia?, Jiayue Xu?, Lidan Zhao, Junyi J, Bingxuan Wu, Yue Ma, Hao Li , Xiaoxia Zuo, Wenyou Pan, Xiaohan Wang, Shuang Ye, George C. Tsokos *, Jun Wang*, Xuan Zhang*. An Autoimmunoogenic and Proinflammatory Profile Defined by the Gut Microbiota of Patients With Untreated Systemic Lupus Erythematosus. Arthritis & Rheumatology, 2021 Feb. 73(2):232-243.
2. 2.Kai Li?, Jiayue Xu?, Yanyun Luo?, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26.
3. 3.Zhengyi Zhang?, Jingnan Pi?, Dongling Zou?, Xiaoshuang Wang?, Jiayue Xu?, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397.
4. 4.Jie Zhou?, Jiayue Xu?, Lingling Zhang?, Siqi Liu?, Yanni Ma?, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, and Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2):285-298.e5.
5. 5.Linping Wang?, Jiayue Xu?, Huchen Li, Lipu Song, Yi Y, Wensheng Zhang, Guiming Liu*, Chengqiang Feng*. The complete mitochondrial genome of Paecilomyces hepiali (Ascomycota, Eurotiomycetes), MITOCHONDRIAL DNA. 2016. 27(2):916-7.
6. 6.Dapeng Wang*?, Jiayue Xu?, Jun Yu *. KGCAK: a K-mer based database for genome-wild phylogeny and complexity evaluation. Biology Direct. 2015 Sep 16. 10(53):1-2.
7. 7.Jiayue Xu?, Jing Sun?, Jinglong Yin?, Liang Wang, Shan Chi, Cui Liu, Lufeng Ren, Xumin Wang*, Tao Liu*, Shuangxiu Wu*, Jun Yu*. Comparative analysis of four essential Gracilariaceae species in China based on whole transcriptomic sequencing. Acta Oceanologica Sinica. 2014. 33(2):54-62.

     高玉風(fēng)，博士，助理研究員

     E-mail: gaoyufeng@ibms.pumc.edu.cn

個(gè)人簡(jiǎn)介

高玉風(fēng)，女，1989年11月生，博士，助理研究員。2018年6月畢業(yè)于中國科學(xué)院北京基因組研究所，基因組學(xué)專(zhuān)業(yè)，理學(xué)博士。2018年7月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生化與分子生物學(xué)系，醫學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗室工作。作為負責人承擔國家自然科學(xué)基金委青年基金項目。作為共同第一作者在國際學(xué)術(shù)期刊Blood上發(fā)表研究論文1篇，作為共作者發(fā)表SCI論文2篇。

目前研究方向為利用組學(xué)數據和生物信息學(xué)手段描述和刻畫(huà)造血干細胞發(fā)育過(guò)程中的分子動(dòng)態(tài)圖譜，以及疾病中的基因組、轉錄組及翻譯組學(xué)研究。

在研項目：

國家自然科學(xué)基金委青年基金項目，2022-2024、腫瘤中異常紅系前體細胞（EPC）的起源及特征分析、主持。

代表性論著(zhù) (? first author; * corresponding author):

1. 1.Xueju Wei?, Yue Huo?, Jingnan Pi?, Yufeng Gao?, Shuan Rao?, Manman He?, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nature Cell Biology. 2022 Aug. 24(8):1278-1290.
2. 2.Yingchi Zhang?, Yufeng Gao?, Hui Zhang?, Jingliao Zhang, Fuhong He, Aleˇs Hn′?zda, Maoxiang Qian, Xiaoming Liu, Yoshihiro Gocho, Ching-Hon Pui, Tao Cheng, Qianfei Wang, Jun J. Yang*, Xiaofan Zhu*, Xin Liu*. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. Blood. 2018 May 17. 131(20):2256-2261.
3. 3.Jingnan Pi?, Wen Wang?, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10):2651-2665.
4. 4.Liu Xin*, Xiumei Hong, Hui-Ju Tsai, Karen K. Mestan, Min Shi, Amira Kefi, Ke Hao, Qi Chen, Guoying Wang, Deanna Caruso, Hua Geng, Yufeng Gao, Jianlin He, Rajesh Kumar, Hongjian Wang, Yunxian Yu, Tami Bartell, Xiao-Di Tan, Robert P. Schleimer, Daniel E. Weeks, Jacqueline A. Pongracic, Xiaobin Wang. Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine. 2018 Mar. 97(9):e0043-e0043.

     王芳

     博士，教授，博士生導師

     國家優(yōu)秀青年科學(xué)基金獲得者

     E-mail: wo_wfang@hotmail.com

個(gè)人簡(jiǎn)介

王芳，女，1983年2月生，教授，博士生導師。2009年畢業(yè)于北京協(xié)和醫學(xué)院，獲博士學(xué)位，后留所工作至今。2012年晉升副教授，2017年晉升教授，同年獲聘博士生導師。作為負責人承擔國家自然科學(xué)基金委青年、面上項目，作為科研骨干參與科技部973項目，國家重點(diǎn)研發(fā)計劃。獲科技部重點(diǎn)研發(fā)計劃”青年科學(xué)家項目” (2022)、國家“優(yōu)秀青年科學(xué)基金”（2021）、醫科院“青年醫學(xué)人才獎勵項目”（2018）、 “協(xié)和新星” (2016)等人才計劃支持。作為第一作者或通訊作者（含共同）在Nature Cell Biology、Cell Research、Nature Communications、Genome Biology、 Cancer Research、Nucleic Acids Research、Autophagy、Oncogene、JBC等國際學(xué)術(shù)期刊發(fā)表SCI論文20篇。獲教育部自然科學(xué)二等獎（2018）。

目前研究方向為轉錄后調控與造血發(fā)育及血液系統疾病。

在研項目：

1.   科技部國家重點(diǎn)研發(fā)計劃干細胞專(zhuān)項，2022-2026、造血發(fā)育及再生的翻譯調控研究、主持。

2.   國家優(yōu)秀青年科學(xué)基金，2021-2023、造血分化調控、主持。

3.   國家自然科學(xué)基金委面上項目，2020-2023、miRNA初級轉錄本作為新型lncRNA調節造血紅系分化的功能和機制研究、主持。

代表性論著(zhù) (? first author; * corresponding author):

1. 1.Qing You?, Fang Wang?, Rong Du, Jingnan Pi, Huayi Wang, Yue Huo, Jingyi Liu, Chen Wang, Jia Yu*, Yanlian Yang*, Ling Zhu*. m6A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation. Adv Mater. 2022 Dec 9:e2204910.
2. 2.Xueju Wei?, Yue Huo?, Jingnan Pi?, Yufeng Gao?, Shuan Rao?, Manman He?, Qinglv Wei, Peng Song, Yiying Chen, Dongxu Lu, Wei Song, Junbo Liang, lingjie Xu, Haixia Wang, Guolin Hong, Yuehong Guo, Yanmin Si, Jiayue Xu, Xiaoshuang Wang, Yanni Ma, Shuyang Yu, Dongling Zou*, Jing Jin*, Fang Wang*, Jia Yu*. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nature Cell Biology. 2022 Aug. 24(8):1278-1290.
3. 3.Fang Wang?, Puwen Tan?, Pengcheng Zhang?, Yue Ren?, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7. 8(1):eabg5369.
4. 4.Yue Ren?, Yue Huo?, Weiqian Li?, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. Nuclear fractionation reveals chromatin-enriched RNA-binding proteins and transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14. 22(1):290.
5. 5.Jingnan Pi?, Wen Wang?, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10): 2651-2665.
6. 6.Yan Huang?, Puwen Tan, Xiaoshuang Wang, Ying Yi, Yongfei Hu, Dong Wang, Wang F*. Transcriptomic insights into temporal expression pattern of autophage genes during monocytic and granulocytic differentiation. Autophagy. 2018 Feb 21. 14(3):558-559.
7. 7.Hongmei Zhao?, Xiaoshuang Wang?, Ping Yi?, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428.
8. 8.Fang Wang?, Wei Song?, Hongmei Zhao?, Yanni Ma, Yuxia Li, Di Zhai, JingnanPi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar. 27(3):416-439.
9. 9.Rui Su?, Lei Dong?, Dongling Zou, Hongmei Zhao, Yue Ren, Feng Li, Ping Yi, Lanfang Li, Yong Zhu, Yanni Ma, Jing Wang, Fang Wang*, Jia Yu*. MicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Nov 17. 35(46):6001-6014.
10. 10.Lanfang Li?, Qingya Luo, Zhe Xie, Guiqin Li, Chengyi Mao, Yi Liu, Xin Wen, Na Yin, Jianzhong Cao, Jing Wang, Li Li, Jianhua Yu, Fang Wang*, Ping Yi*. Characterization of the expression of the RNA binding protein eIF4G1 and its clinicopathological correlation with serous ovarian cancer. PLoS One. 2016 Sep 26. 11(9):e0163447.
11. 11.Peng-Fei Zhai?, Fang Wang?, Rui Su, Hai-Shuang Lin, Chong-Liang Jiang, Gui-Hua Yang, Jia Yu, Jun-Wu Zhang*. The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis. J Biol Chem. 2014 Aug 15. 289(33):22600-13.
12. 12.Yuxia Li, Hua Bai, Zhongzu Zhang, Weihua Li, Lei Dong, Xueju Wei, Yanni Ma, Junwu Zhang, Jia Yu, Guotao Sun*, Fang Wang*. The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2. Mol. Cells. 2014 Mar. 37(3):1-7.
13. 13.Fang Wang?, Yong Zhu?, Lihua Guo?, Lei Dong, Huiwen Liu, Haixin Yin, Zhongzu Zhang, Yuxia Li, Changzheng Liu, Yanni Ma, Wei Song, Aibin He, Qiang Wang, Linfang Wang, Junwu Zhang, Jianxiong Li, Jia Yu*. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Research. 2014 Jan. 42(1):442-57.
14. 14.Yong Zhu?, Dongsheng Wang?, Fang Wang?, Tingting Li, Lei Dong, Huiwen Liu, Yanni Ma, Fengbing Jiang, Haixin Yin, Wenting Yan, Ming Luo, Z Tang, Guoyuan Zhang, Qiang Wang, Junwu Zhang, Jingguo Zhou, Jia Yu*. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Research. 2013 Apr. 41(7):4129-43.
15. 15.Fang Wang?, Xiao-Shuang Wang, Gui-Hua Yang, Peng-Fei Zhai, Peng-Fei Zhai, Zhen Xiao, Liang-Yu Xia, Li-Rong Chen, Yu Wang, Xiao-Zhong Wang, Lai-Xi Bi, Nian Liu, Yang Yu, Da Gao, Bin-Tao Huang, Jing Wang, Dao-Bin Zhou, Jia-Nan Gong, Hua-Lu Zhao, Xiu-Hua Bi, Jia Yu, Jun-Wu Zhang*. miR-29a and miR-142-3p downregulation and diagnostic implication in human acute myeloid leukemia. Mol Biol Rep. 2012 Mar. 39(3):2713-22.
16. 16.Fang Wang?, Jia Yu, Guihua Yang, Xiaoshuang Wang, Junwu Zhang*. Regulation of erythroid differentiation by miR-376a and its targets. Cell Research. 2011 Aug. 21(8): 1196-209.
17. 17.Jin-Yun Yuan?, Fang Wang?, Jia Yu?, Gui-Hua Yang,Xiao-Ling Liu, Jun-Wu Zhang*. MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells. J. Cell. Mol. Med. Nov-Dec 2009. 13(11-12):4551-9.
18. 18.Jia Yu?, Fang Wang?, Gui-Hua Yang, Fan-Long Wang, Yan-Ni Ma, Zhan-Wen Du, Jun-Wu Zhang*. Human miRNA Clusters: genomic organization and expression profile in leukemia cell lines. Biochem Biophy Res Commun. 2006 Oct 13. 349(1):59-68.