劉力

介紹：劉力,男，博士，研究員，博士生導師。康奈爾大學醫(yī)學院博士后，南開大學分子病毒學博士。從1991年1月起,先后在美國國家動物疾病中心、康奈爾大學醫(yī)學院及斯隆凱特林研究所(Sloan Kettering)從事多年動物呼吸道病毒的免疫生物學及人腺病毒轉錄后期RNA加工的基因調控等方面的研究工作。1998年6月回國，歷任中國醫(yī)學科學院基礎醫(yī)學研究所/北京協(xié)和醫(yī)學院基礎學院病原微生物研究室副研究員，研究員，博士研究生指導教師。2001-2007,清華大學基因組研究所兼職副教授，博士研究生副指導教師。2004年起任《基礎醫(yī)學與臨床》常務編委。2014年起《Frontiers in Bioscience》執(zhí)行編輯(managing editor),2017年起任編輯(editor)。2016年起《轉化醫(yī)學電子雜志》編委， 2017年起《轉化醫(yī)學電子雜志》學術委員。2017年起為《Cancer Translational Medicine》雜志編委。現為美國微生物學會貢獻會員，歐美同學會醫(yī)師學會會員，中國微循環(huán)學會會員，中國微循環(huán)學會轉化醫(yī)學專業(yè)委員會常務委員。國家科技重大專項-重大新藥創(chuàng)制（2017）答辯專家，國家自然科學基金委員會面上項目函審專家，北京市自然科學基金面上項目函審專家、北京市豐臺區(qū)科委重點項目答辯專家、天津市自然科學基金面上項目及杰出青年基金函審專家，天津市自然科學基金委員會杰出青年基金答辯專家、浙江省自然科學基金項目函審專家，四川省科學技術獎勵函審專家，河北省自然科學基金函審專家，黑龍江省自然科學基金函審專家，教育部學位中心學位論文函審專家。為The Lancet, Molecular Pharmaceutics, PLoS One, BBA-Molecular Cell Research, Antiviral Res, BMC Cancer等十八家國際SCI期刊同行評議專家。在中文核心期刊及SCI期刊發(fā)表研究論文共70余篇，其中在Cancer Res, mBio, Mol Cell Biol等國際主流雜志發(fā)表SCI研究論文32篇（第一及通訊作者文章27篇）。已培養(yǎng)畢業(yè)碩士研究生18名，博士研究生9名。

聯(lián)系方式：辦公室電話: 69156454

          電子郵件地址: lliu@pumc.edu.cn

          通信地址: 北京市東城區(qū)東單三條五號老科研樓336室

主要英文論文 (*通訊或共同通訊作者)

1. Yajuan Gao, Li Liu*. Multifunction of cytosolic DNA sensor. Journal of Advances in Health, 2019, 1(1): 49-56.

2. Sulin Zeng, Wen H. Shen*, Li Liu*. Senescence and Cancer. Cancer Translational Medicine 2018, 4(3):70-74. 

3. Li Liu*, Wei Chen. Leader sequences of coronavirus are altered during infection. Frontiers in Bioscience-Landmark, 2018, Jan 1, 23: 27-35.

4. Yi-Rong Xiang, Li Liu*，2Eating2 cancer cells by blocking CD47 signaling: cancer therapy by targeting the innate immune checkpoint. Cancer Translational Medicine 2017, 3(6):200-208.

5. We-Ye Shi, Xiao Yang, Bo Huang, Wen H Shen, Li Liu*. NOK mediates glycolysis and nuclear PDC associated histone acetylation. Frontiers in Bioscience-Landmark, 2017, 22:1792-1804.

6.Shi WY, Cao C, Li Liu*. Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway. Int J Mol Sci. 2016 Nov 2;17(11). pii: E1832.

7. Yi Wang and Li Liu*. The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern to Promote Beta Interferon Induction via a Toll-Like- Receptor-Related TRAF3-Independent Mechanism. mBio, 2016,(1): e01872- 15. (Cover story)  

8. Zhiqiang Xia, Fang Liu, Jian Zhang and Li Liu*. Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion. PLoS One, 2015, 10(7):e0132399.   

9. Sheng-Qi Hou and Li Liu*. NOK mediated mitogenic signaling is altered by P203L and V395I mutations. Front Biosci (Landmark Ed), 2015, 20:1179-89.       

10. Xu G, Gao Z, He W, Ma Y, Feng X, Cai T, Lu F, Liu L, Li W*. microRNA expression in hepatitis B virus infected primary treeshrew hepatocytes and the independence of intracellular miR-122 level for de novo HBV infection in culture. Virology. 2014 Jan 5;448:247-54..

11. Shi WY, Che CY, Li Liu*. Human interleukin 23 receptor induces cell apoptosis in mammalian cells by intrinsic mitochondrial pathway associated with the down-regulation of RAS/mitogen-activated protein kinase and signal transducers and activators of transcription factor 3 signaling pathways. Int J Mol Sci. 2013 Dec 18;14(12):24656-69..

12. Rong Guo, Yi Wang, Wei-Ye Shi, Bin Liu, Sheng-Qi Hou and Li Liu*. MicroRNA miR-491-5p Targeting both TP53 and Bcl-XL Induces Cell Apoptosis in SW1990 Pancreatic Cancer Cells through Mitochondria Mediated Pathway. Molecules 2012, 17(12), 14733-14747.   

13. Ying-Li Cao, Ying Wang, Rong Guo, Fan Yang, Yun Zhang, Shu-Hui Wang, Li Liu*. Identification and characterization of three novel small interference RNAs that effectively down-regulate the isolated nucleocapsid gene expression of SARS coronavirus. Molecules, 2011 Feb 11;16(2):1544-58.   

14. Ying Wang, Ying-Li Cao, Fan Yang, Yun Zhang, Shu-Hui Wang, Li Liu*. Small interfering RNA effectively inhibits the expression of SARS coronavirus membrane gene at two novel targeting sites. Molecules, 2010 Oct 18;15(10):7197-207.   

15. Xue Yao, Yang Su, Chang Liu, Juan Tan, Li Liu, Yun-Qi Geng, Wen-Tao Qiao*. Establishment of an indicator cell line for monitoring bovine immunodeficiency virus infection and inhibitor susceptibility. J Virol Methods. 2010 Jan;163(1):25-30.

16. Fan Yang, Yu-Ping Xu, Jian Li, Su-Su Duan, Ying-Jie Fu, Yun Zhang, Yan Zhao, Wen-Tao Qiao, Qi-Min Chen, Yun-Qi Geng, Chang-Yan Che, Ying-Li Cao,Ying Wang, Lei Zhang, Lin Long, Jie He, Quan-Cai Cui, Shu-Chang Chen, Shu-Hui Wang, Li Liu*. 2009. Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression. The International Journal of Biochemistry and Cell Biology, 41(11):2240-2250.   

17. Li Liu, Jian Li, Yu-Ping Xu, Wen-Tao Qiao, Qi-Min Chen, Yun-Qi Geng*. RNA silencing suppressor p19 regulates the expressions of cell cycle related genes. Progress in Biochemistry and Biophysics (rapid communications), 2009 May, 36(5): 541-548. 

18. Ying-Hua Li, Yin-Yin Wang, Shan Zhong, Zhi-Li Rong, Yong-Ming Ren, Zhi-Yong Li, Shu-Ping Zhang, Zhi-Jie Chang, Li Liu*. Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling. 2009 January, Mol Cells, Vol. 27(1): 39-45.

19. Ying-Hua Li, Yu Rong, Zhijie Chang, Li Liu*. 2008. NOK activates stat3 signaling by a Jak2-dependent mechanism. Progress in Biochemistry and Biophysics (rapid communications), 35(2):143-150.   

20. Ying-Hua Li, Zhijie Chang, Li Liu*. 2008. NOK interacts with akt and enhances its activation. Progress in Biochemistry and Biophysics (rapid communications), 35(1):29-34.

21. Zhe Ma, Peng Hao, Xue Yao, Chang Liu, Juan Tan, Li Liu, Rongge Yang, Yunqi Geng, Qimin Chen* and Wentao Qiao*. 2008. Establishment of an indicator cell line to quantify Bovine Foamy Virus infection. Journal of Basic Microbiology, 48(4): 278–283.

22. Ying-Hua Li, Shan Zhong, Zhi-Li Rong, Yong-Ming Ren, Zhi-Yong Li, Shu-Ping Zhang, Zhijie Chang, Li Liu*. 2007. The carboxyl terminal tyrosine 417 residue of NOK has an autoinhibitory effect on NOK-mediated signaling transductions. Biochemical and Biophysical Research Communications, 356(2):444-9.

23. Li Liu*. 2006. Functional characterization of the C-terminal domain of mouse capping enzyme. Cell Biochemistry and Function, 35(2):143-150;   

24. Yu Rong, Long Cheng, Hongxiu Ning, Jizhen Zou, Yuanjiang Zhang, Fang Xu, Li Liu, Zhijie Chang*, and Xin-Yuan Fu*. 2006. Wilms' Tumor 1 and Signal Transducers and Activators of Transcription 3 Synergistically Promote Cell Proliferation: A Possible Mechanism in Sporadic Wilms' Tumor. Cancer Res, 66: 8049-8057.   

25. Xiang-Yue Zhang, Hai-Jing Zhang, Yun Zhang, Ying-Jie Fu, Jie He, Li-Ping Zhu, Shu-hui Wang, Li Liu*. 2006. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics, Vol 57(12): 934-943.   

26. Tie-Shi Li, Xue-Ni Li, Zhi-Jie Chang, Xin-Yuan Fu, and Li Liu*. 2006. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen- activated protein kinase signaling pathway. Cellular Signaling, 18(8):1287-98.   

27. Li Liu*. 2005. Characterization of an upstream regulatory element of adenovirus L1 poly (A) site. Virology, 337(1):124-35.   

28. Yue Chen, Ying-Hua Li, Xi-Ping Chen, Li-Ming Gong, Shu-Ping Zhang, Zhi-Jie Chang, Xiu-Fang Zhang*, Xin-Yuan Fu*, and Li Liu*. 2005. Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Cancer Res.65 (23): 10838-10846.   

29. Fan Yang, Yun Zhang, Ying-Li Cao, Shu-Hui Wang , and Li Liu*. 2005. Establishment and utilization of a tetracycline-controlled inducible RNA interfering system to repress gene expression in chronic myelogenous leukemia cells. Acta Bioch. Biophys. Sin. (Shanghai), 37(12):851-6.   

30．Li Liu*, Xin-Zi Yu, Tie-Shi Li, Lian-Xia Song, Pei-La Chen, Ying-Hua Li, Shi-Dong Wang, Yue Chen, Yong-Ming Ren, Shu-Ping Zhang, Zhi-Jie Chang, and Xin-Yuan Fu*. 2004. A novel protein tyrosine kinase NOK that shares homology with PDGF/FGF receptors, induces tumorigenesis and metastasis in nude mice. Cancer Res., 64 (10): 3491-3499..

31．Shiqin Xiong, Qiuhui Zhao, Zhili Rong, Guanrong Huang, Yiling Huang, Peila Chen, Shuping Zhang, Li Liu, Zhijie Chang*. 2003. hSef inhibits PC-12 cell differentiation By interfering with Ras-mitogen-activated protein kinase MAPK signaling. J Biol Chem, 278(50):50273-82.   

32. Li Liu, Howard D. Lehmkuhl*, and Malin L. Kaeberle. 1999. Synergistic effects of bovine respiratory syncytial virus and non-cytopathic bovine viral diarrhea virus on selected bovine alveolar macrophage functions. Can.J. Vet.Med., 63(1): 41-48.   

33．Li Liu*, Shuhui Wang. 1999. The reversible inhibition of mimosine on rDNA plasmid replication in unfertilized Xenopus eggs. Chinese Science Bulletin, Vol 44(18): 1669-1672.   

34．John C. Prescott#, Li Liu#, and Erik Falck-Pedersen*. 1997. Sequence- mediated regulation of adenovirus gene expression by repression of mRNA accumulation. Mol. Cell. Biol., 17:2207-2216. (#equal contribution，1997 SCI IF=10.025)

教材與專著章節(jié)（近5年）

1） 劉力參編，第四章 病毒DNA基因組復制。【分子病毒學】第三版/研究生，主編 黃文林，人民衛(wèi)生出版社，出版時間：2016年6月。書號ISBN：9787117219020;

2） 劉力參編，第三十一章 其他重要病毒。【醫(yī)學微生物學學習指導及習題集】，主編 李明遠，人民衛(wèi)生出版社，2016年3月第1版, 2016年3月第一次印刷  p233-240。書號 ISBN 978-7-117-21777-4/R·21778;

3） Li Liu. Chapter 19. The NOK receptor family, book name: Receptor Tyrosine kinases: family and subfamilies, edited by Deric L. Wheeler and Yosef Yarden, published in January 2015 by Humana Press, p843－859.  

4） 劉力參編，第三十一章 其他重要病毒。【醫(yī)學微生物學】第三版/長學制，主編 李明遠、徐志凱，人民衛(wèi)生出版社，2015年6月第3版第一次印刷，p413－429.書號 ISBN 978-7-117-20499-6/R × 20500;