陳等

陳等，男，1994年畢業(yè)于蘭州醫學(xué)院預防醫學(xué)系，獲醫學(xué)學(xué)士學(xué)位。1997年畢業(yè)于西安醫科大學(xué)公共衛生學(xué)院勞動(dòng)衛生與衛生毒理學(xué)專(zhuān)業(yè)，獲醫學(xué)碩士學(xué)位。2003年畢業(yè)于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生物化學(xué)與分子生物學(xué)專(zhuān)業(yè)，獲理學(xué)博士學(xué)位。2004.11-2010.7在美國伯明翰阿拉巴馬大學(xué)醫學(xué)院藥理毒理學(xué)系及綜合癌癥中心做博士后。2010年12月至今在中國醫學(xué)科學(xué)院基礎醫學(xué)研究所生物化學(xué)與分子生物學(xué)系工作，副研究員，碩士研究生導師，主要研究方向為腫瘤發(fā)病分子機制和真核基因表達調控等。目前主持國家自然科學(xué)基金面上項目一項，參加中國醫學(xué)科學(xué)院醫學(xué)與健康科技創(chuàng )新工程項目一項。

聯(lián)系方式：

地址：北京市東城區東單三條5號醫科院基礎所老科研樓658房間

郵編：100005

電話(huà)：010-69156980

Email: chendeng2001@hotmail.com

代表性論文（^#第一作者，^*通訊作者）：

1. Zhao W^#, Zhang S, Wang X, Ma X, Huang B, Chen H, Chen D*. ETS1 targets RYBP transcription to inhibit tumor cell proliferation. Biochem Biophys Res Commun.2019, 509(3):810-816.

2. Li Meng^#, Zhang Shiqiang, Zhao Wen, Hou Congcong, Ma Xiaoli, Li Xuekun, Huang Bingren, Chen Hong, Chen Deng*. RYBP modulates stability and function of Ring1B through targeting UBE3A. FASEB J. 2019, 33(1):683-695.

3. Zhao Q^#, Cai W^#, Zhang X, Tian S, Zhang J, Li H, Hou C, Ma X, Chen H, Huang B^*, Chen D^*. RYBP expression is regulated by KLF4 and Sp1 and is related to hepatocellular carcinoma prognosis. J Biol Chem. 2017, 292(6):2143-2158.

4. Tan K^#, Zhang X^#, Cong X, Huang B, Chen H^*, Chen D^*. Tumor suppressor RYBP harbors three nuclear localization signals and its cytoplasm-located mutant exerts more potent anti-cancer activities than corresponding wild type. Cell Signal. 2017, 29(1):127-137.

5. Ma W^#, Zhang X^#, Li M, Ma X, Huang B, Chen H^*, Chen D^*. Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway. Cell Signal. 2016, 28(8):779-87.

6. Tian S, Hui X, Fan Z, Li Q, Zhang J, Yang X, Ma X, Huang B^*, Chen D^*, Chen H^*. Suppression of hepatocellular carcinoma proliferation and hepatitis B surface antigen secretion with interferon-l1 and PEG-interferon-l1. FASEB J. 2014, 28(8):3528-39.

7. Zhang J, Ma W, Tian S, Fan Z, Ma X, Yang X, Zhao Q, Tan K, Chen H^*, Chen D^*, Huang BR^*. RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI. Cell Signal. 2014, 26(1): 162–172.

8. Chen D^#, Wang W, Qin JJ, Wang MH, Murugesan S, Nadkarni DH, Velu SE, Wang H, Zhang R^*. Identification of the ZAK-MKK4-JNK-TGFβSignaling Pathway as a Molecular Target for Novel Synthetic Iminoquinone Anticancer Compound BA-TPQ. Curr Cancer Drug Targets. 2013, 13(6): 651-660.

9. Chen D^#, Zhang J, Li M, Rayburn ER, Wang H, Zhang R^*. RYBP stabilizes p53 by modulating MDM2. EMBO Rep. 2009, 10(2): 166-72.

10. Chen D^#, Zhang Z^#, Li M, Wang W, Li Y, Rayburn E R, Hill D L, Wang H^* and Zhang R^*. Ribosomal protein S7 as a novel modulator of p53–MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.  Oncogene. 2007, 26(35):5029–37.

11. Chen D^#, Zhang JW*, Zhang ZX, Wu YN, Qu QM. Association of a2-macroglobulin polymorphisms and Alzheimer disease in Mainland Chinese. J Neurol Sci. 2004, 217(1):13-15.

12. Li XQ^#, Chen D^#, Zhang ZX, Qu QM, Zhang JW*. Genetic Association between Cathepsin D Polymorphism and Alzheimer’s Disease in Chinese Han Population. Dement Geriatr Cogn Disord. 2004,18(2):115-119.