朱蕾
朱蕾，醫學(xué)博士，教授，研究生導師。現任中國藥理學(xué)會(huì )抗炎免疫藥理專(zhuān)業(yè)委員會(huì )委員，中國藥理學(xué)會(huì )抗炎免疫藥理專(zhuān)業(yè)委員會(huì )青年委員會(huì )常務(wù)委員，中國藥理學(xué)會(huì )表觀(guān)遺傳藥理學(xué)專(zhuān)業(yè)委員會(huì )委員，《醫藥導報》青年編委，教育部學(xué)位中心評議專(zhuān)家，北京市自然科學(xué)基金評審專(zhuān)家。2016年，獲“中國藥理學(xué)會(huì )青年藥理學(xué)家獎”。
承擔和參與包括國家自然科學(xué)基金、科技部“十一五”和“十二五”重大新藥創(chuàng )制科技重大專(zhuān)項、中國醫學(xué)科學(xué)院醫學(xué)與健康科技創(chuàng )新工程項目等多項課題。發(fā)表研究論文三十余篇，擔任British Journal of Pharmacology，Journal of Pharmacology and Experimental Therapeutics，Brain Behavior and Immunity，European Journal of Inflammation等雜志審稿人。
研究方向：
1. 抗炎免疫藥理學(xué)：炎癥免疫性疾病發(fā)病機制、新靶點(diǎn)及新藥物研究，并采用小分子探針技術(shù)，結合細胞生物學(xué)和分子生物學(xué)方法，進(jìn)行藥物靶分子篩選和作用機制探討。
2. 創(chuàng )新藥物基礎和臨床研究：新型抗自身免疫性疾病藥物羧胺三唑的臨床前研究以及羧胺三唑臨床新用途的研究，并與北京協(xié)和醫院風(fēng)濕免疫科協(xié)作開(kāi)展相關(guān)轉化醫學(xué)研究。
聯(lián)系方式：
leizhu2004@126.com
Tel: 010-69156402
代表性論文：
1. Shan Lu, Mengyuan Duan, Zehao Guo, Yongting Zhou, Danwei Wu, Xiaojuan Zhang, Yicheng Wang, Caiying Ye, Rui Ju, Juan Li, Dechang Zhang, Lei Zhu. Carboxyamidotriazole exerts anti-inflammatory activity in lipopolysaccharide?induced RAW264.7 macrophages by inhibiting NF-κB and MAPKs pathways. Exp Ther Med. 2020, 20: 1455-1466.
2. Bingqing Zhang, Mengyuan Duan, Bo Long, Baozhong Zhang, Dongmei Wang, Yun Zhang, Jialin Chen, Xiaoming Huang, Yang Jiao, Lei Zhu, Xuejun Zeng. Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes. Mol Med Rep. 2019, 20: 1645-1654.
3. Ting-Ting Zhang, Rui Xue, Shi-Yong Fan, Qiong-Yin Fan, Lei An, Juan Li, Lei Zhu, Yu-Hua Ran, Li-Ming Zhang, Bo-Hua Zhong, Yun-Feng Li, Cai-Ying Ye, You-Zhi Zhang. Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord. J Neuroinflammation. 2018, 5: 176.
4. Xiaowan Du, Wei Chen, Yufeng Wang, Chen Chen, Lei Guo, Rui Ju, Juan Li, Dechang Zhang, Lei Zhu, Caiying Ye. Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation. Int Immunopharmacol. 2017, 45: 16-25.
5. Ting-ting Zhang, Rui Xue, Lei Zhu, Juan Li, Qiong-yin Fan, Bo-hua Zhong, Yun-feng Li, Cai-ying Ye, and You-zhi Zhang. Evaluation of the analgesic effects of ammoxetine, a novel potent serotonin and norepinephrine reuptake inhibitor. Acta Pharmacol Sin. 2016, 37: 1154-1165.
6. Lei Zhu, Juan Li, Lei Guo, Xiaoli Yu, Danwei Wu, Lifeng Luo, Lingzhi Zhu, Wei Chen, Chen Chen, Caiying Ye, Dechang Zhang. Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis. Brit J Pharmacol. 2015, 172: 3446-3459.