劉曉軍

研究方向：2型糖尿病分子病理機制研究和藥物篩選

介紹：劉曉軍，男，研究員，博士研究生導師。主要從事2型糖尿病分子病理機制研究和藥物篩選。參與研究的項目《中國人2型糖尿病易感基因生物學(xué)功能及作用機制的研究》獲2008年中華醫學(xué)科技獎三等獎。2011年獲北京協(xié)和醫學(xué)院人才發(fā)展規劃“協(xié)和新星”資助。2011年獲醫科院基礎所“先進(jìn)科研工作者”稱(chēng)號。國家自然科學(xué)基金，北京市自然科學(xué)基金評審專(zhuān)家。Cell Proliferation、Plos One等雜志審稿專(zhuān)家。發(fā)表學(xué)術(shù)論文30余篇。

聯(lián)系方式：Email: xiaojunliu@ibms.pumc.edu.cn      Tel: 010-69156424

代表性論文： (* Corresponding author)

(1) Gao M, Zhao W, Li C, Xie X, Li M, Bi Y, Fang F, Du Y*, Liu X*. Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. Biochem Biophys Res Commun. 2018 Oct 20;505(1):93-98. doi: 10.1016/j.bbrc.2018.09.078. Epub 2018 Sep 18.

(2) Geng C, Xu H, Zhang Y, Gao Y, Li M, Liu X, Gao M, Wang X, Liu X*, Fang F*, Chang Y*. Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. Sci China Life Sci. 2017 Nov;60(11):1234-1241. doi: 10.1007/s11427-016-9027-6. Epub 2017 Jun 29.

(3) Yang YG, Li MX, Kou L, Zhou Y, Qin YW, Liu XJ*, Chen Z*. Long Noncoding RNA Expression Signatures of Abdominal Aortic Aneurysm Revealed by Microarray. Biomed Environ Sci. 2016 Oct;29(10):713-723.

(4) Zhang Y, Geng C, Liu X, Li M, Gao M, Liu X*, Fang F*, Chang Y*. Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1. Mol Metab. 2016 Nov 17;6(1):138-147. doi: 10.1016/j.molmet.2016.11.002. eCollection 2017 Jan.

(5) Geng C, Zhang Y, Gao Y, Tao W, Zhang H, Liu X*, Fang F*, Chang Y*. Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice. Biochem Biophys Res Commun. 2016 Mar 18;471(4):444-9. doi: 10.1016/j.bbrc.2016.02.059. Epub 2016 Feb 20.

(6) Liu X*, Gao Y, Li M, Geng C, Xu H, Yang Y, Guo Y, Jiao T, Fang F*, Chang Y*. Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet. J Hepatol. 2015 Sep;63(3):713-21. doi: 10.1016/j.jhep.2015.05.018. Epub 2015 May 27.

(7) Liu X*, Cui Y, Li M, Xu H, Zuo J, Fang F*, Chang Y*. Cobalt protoporphyrin induces HO-1 expression mediated partially by FOXO1 and reduces mitochondria-derived reactive oxygen species production. PLoS One. 2013 Nov 8;8(11):e80521. doi: 10.1371/journal.pone.0080521. eCollection 2013.

(8) Liu X, Qiao A, Ke Y, Kong X, Liang J, Wang R, Ouyang X, Zuo J, Chang Y, Fang F. FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells. FEBS Lett. 2010 Oct 22;584(20):4330-4. doi: 10.1016/j.febslet.2010.09.027. Epub 2010 Sep 23.

(9) Liu X, Feng Q, Chen Y, Zuo J, Gupta N, Chang Y, Fang F. Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. J Proteome Res. 2009 Mar;8(3):1255-62. doi: 10.1021/pr800850a.

(10) Liu XJ, Yang C, Gupta N, Zuo J, Chang YS, Fang FD. Protein kinase C-zeta regulation of GLUT4 translocation through actin remodeling in CHO cells. J Mol Med (Berl). 2007 Aug;85(8):851-61. Epub 2007 Jul 10.