張衛奇課題組

張衛奇，生物醫學(xué)工程系課題組長(cháng)，副研究員，碩士生導師；

2004.09-2008.07于湖南師范大學(xué)生物技術(shù)專(zhuān)業(yè)獲學(xué)士學(xué)位；

2008.09-2013.07于北京協(xié)和醫學(xué)院生物醫學(xué)工程專(zhuān)業(yè)獲博士學(xué)位；

2014.02-2018.12 在康奈爾大學(xué)醫學(xué)院放射醫學(xué)系做博士后研究；

2019.02加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所&北京協(xié)和醫學(xué)院基礎學(xué)院生物醫學(xué)工程系，任課題組長(cháng)。目前，作為負責人承擔了北京市科技新星計劃、中國醫學(xué)科學(xué)院創(chuàng )新工程子課題、協(xié)和青年基金和國家重點(diǎn)實(shí)驗室自主課題等課題任務(wù)。

研究方向：

課題組主要研究領(lǐng)域為藥物遞送與分子影像，旨在利用基礎醫學(xué)、生物學(xué)、藥學(xué)與材料學(xué)等多學(xué)科交叉的研究手段，提高腫瘤等疾病治療和診斷的效率。相關(guān)成果已在ACS Nano、Biomaterials、 Journal of Controlled Release、 ACS Materials Letters與Carbohydrate Polymers等專(zhuān)業(yè)期刊發(fā)表論文35篇，其中第一作者/通訊作者（含共同）論文22篇。申請中國專(zhuān)利3項，參與制定中國國家標準2項。近期課題組研究方向將主要包括：

（1）以藥物-天然生物大分子相互作用為基礎的納米藥物載體設計和應用。

（2）多功能納米藥物在腫瘤成像與治療中的應用。

（3）納米生物材料（藥物載體）的細胞生物學(xué)效應。

教學(xué)工作：

研究生課程《生物醫學(xué)光學(xué)》課程負責人，另外承擔了八年制、“4+4”臨床醫學(xué)試點(diǎn)班和研究生《生物醫學(xué)工程》、《納米醫學(xué)概論》、《生物物理學(xué)》和《生理學(xué)的物理分析》課程的部分授課任務(wù)。

聯(lián)系方式：

北京市東城區東單三條5號，可勝大樓 129

電話(huà)：010-69156937

郵箱： zwq ibms.pumc.edu.cn

課題組成員：

課題組工作人員：

鄧虹，博士，助理研究員

2012年于中國科學(xué)院化學(xué)研究所獲博士學(xué)位。2012-2020年于中國科學(xué)院化學(xué)研究所任助理研究員。2020年加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所任助理研究員。主要研究方向為腫瘤光動(dòng)力治療，迄今已在Journal of Medicinal Chemistry、Carbohydrate Polymers、Journal of Biomedical Nanotechnology和 Dyes and Pigments 等期刊發(fā)表論文10余篇，申請中國專(zhuān)利3項。

張憶一，博士，助理研究員

2021年1月博士畢業(yè)于北京科技大學(xué)化學(xué)專(zhuān)業(yè)，同年9月加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所任助理研究員。主要研究方向為納米藥物載體與光熱治療應用，迄今已在Nano Today, Advanced Healthcare Materials和Analytica Chimica Acta等期刊發(fā)表論文10余篇。

課題組學(xué)生：

高夢(mèng)涵，博士研究生，本科畢業(yè)于中央民族大學(xué)生物學(xué)專(zhuān)業(yè)

劉潤萌，碩士研究生，本科畢業(yè)于四川大學(xué)藥學(xué)專(zhuān)業(yè)

侯偉， 碩士研究生，本科畢業(yè)于四川大學(xué)生物學(xué)專(zhuān)業(yè)

李嘉怡，碩士研究生，本科畢業(yè)于鄭州大學(xué)藥學(xué)專(zhuān)業(yè)

茍小蓉，碩士研究生，本科畢業(yè)于沈陽(yáng)藥科大學(xué)藥學(xué)專(zhuān)業(yè)

張紫紋，訪(fǎng)問(wèn)學(xué)生

陳佳鈺，訪(fǎng)問(wèn)學(xué)生

已畢業(yè)學(xué)生：

王慧敏

發(fā)表論文 (*通訊作者，#第一作者)

1. Hong Deng, Xue Yang, Huimin Wang, Menghan Gao, Yiyi Zhang, Runmeng Liu, Haiyan Xu*, Weiqi Zhang*. Tailoring the surface charges of iron-crosslinked dextran nanogels towards improved tumor-associated macrophage targeting. Carbohydrate Polymers. 2024, 325, 121585.

2. Menghan Gao, Hong Deng, Yiyi Zhang, Huimin Wang, Runmeng Liu, Wei Hou, Weiqi Zhang*. Hyaluronan nanogel co-loaded with chloroquine to enhance intracellular cisplatin delivery through lysosomal permeabilization and lysophagy inhibition. Carbohydrate Polymers. 2024, 323, 121415.

3. Huimin Wang, Hong Deng, Menghan Gao, Yiyi Zhang, Runmeng Liu, Wei Hou, Haiyan Xu*, and Weiqi Zhang*. Radiotherapy Potentiates the P-Selectin Targeted Cancer Drug Delivery Based on a Cisplatin and Mitoxantrone Coassembled Fucoidan Nanogel. ACS Materials Letters. 2023, 5, 2843. (Cover Article)

4. Hua Guo#, Huimin Wang#, Hong Deng, Yiyi Zhang, Xue Yang*, Weiqi Zhang*. Facile preparation of toluidine blue-loaded DNA nanogels for anticancer photodynamic therapy, Frontiers in Bioengineering and Biotechnology. 2023, 11, 1180448.

5. Weiqi Zhang*, Baoji Du, Menghan Gao, Ching-Hsuan Tung*. A hybrid nanogel to preserve lysosome integrity for fluorescence imaging. ACS Nano. 2021, 15, 16442.

6. Huimin Wang, Hong Deng, Menghan Gao, Weiqi Zhang*. Self-assembled nanogels based on ionic gelation of natural polysaccharides for drug delivery. Frontiers in Bioengineering and Biotechnology. 2021, 9, 703559.

7. Menghan Gao, Hong Deng, Weiqi Zhang*. Hyaluronan based multifunctional nano-carriers for combination cancer therapy. Current Topics in Medicinal Chemistry. 2021, 21, 126.

8. Doudou Yan#, Hui Wei#, Xinning Lai, Yangyang Ge, Shilin Xu, Jie Meng, Tao Wen, Jian Liu, Weiqi Zhang*, Jianxiang Wang*, Haiyan Xu*. Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy of refractory acute myeloid leukemia. Journal of Controlled Release. 2020, 327, 766.

9. Weiqi Zhang#, Bo Han#, Xinning Lai, Chen Xiao, Shilin Xu, Xianghui Meng, Zifu Li, Jie Meng, Tao Wen, Xiangliang Yang, Jian Liu, Haiyan Xu. Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells. Chemical Communications. 2020, 56, 1255.

10. Weiqi Zhang, Ching-Hsuan Tung. Lysosome enlargement enhanced photochemotherapy using a multifunctional nanogel. ACS Applied Materials & Interfaces. 2018, 10, 4343.

11. Weiqi Zhang, Ching-Hsuan Tung. Redox-responsive cisplatin nanogel for anticancer drug delivery. Chemical Communications, 2018, 54, 8367.

12. Weiqi Zhang, Ching-Hsuan Tung. Real-time visualization of lysosome destruction using a photosensitive toluidine blue nanogel. Chemistry-A European Journal. 2018, 24, 2089.

13. Weiqi Zhang#, Xianghui Meng#, Huike Liu, Lifei Xie, Jian Liu, Haiyan Xu. Ratio of polycations and serum is a crucial index determining the RNAi efficiency of polyplexes. ACS Applied Materials & Interfaces. 2017, 9, 43529.

14. Weiqi Zhang, Ching-Hsuan Tung. Sequence-independent DNA nanogel as a potential drug carrier. Macromolecular Rapid Communications. 2017, 38, 1700366.

15. Weiqi Zhang, Ching-Hsuan Tung. Cisplatin cross-linked multifunctional nanodrugplexes for combination therapy. ACS Applied Materials & Interfaces. 2017, 9, 854.

16. Weiqi Zhang, Zhe Zhang, Ching-Hsuan Tung. Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels. Chemical Communications. 2017, 53, 779.

17. Weiqi Zhang#, Jian Liu#, Yasuhiko Tabata, Jie Meng, Haiyan Xu. The effect of serum in culture on RNAi efficacy through modulation of polyplexes size. Biomaterials, 2014, 35, 567.

18. Weiqi Zhang, Yinglu Ji, Xiaochun Wu, Haiyan Xu. Trafficking of gold nanorods in breast cancer cells: uptake, lysosome maturation and elimination. ACS Applied Materials & Interfaces, 2013, 5, 9856.

19. Weiqi Zhang, Yinglu Ji, Jie Meng, Xiaochun Wu, Haiyan Xu. Probing the behaviors of gold nanorods in metastatic breast cancer cells based on UV-vis-NIR absorption spectroscopy. PLoS one, 2012, 7, e31957.

20. Weiqi Zhang#, Jie Meng#, Yinglu Ji, Xiaojin Li, Hua Kong, Xiaochun Wu, Haiyan Xu. Inhibiting metastasis of breast cancer cells in vitro using gold nanorod-siRNA delivery system, Nanoscale, 2011, 3, 3923.

21. Xuelian Cheng#, Weiqi Zhang#, Yinglu Ji, Jie Meng, Hua Guo, Jian Liu, Xiaochun Wu, Haiyan Xu. Revealing silver cytotoxicity using Au Nanorods/Ag shell nanostructures: disrupting cell membrane and causing apoptosis through oxidative damage, RSC advances, 2013, 3, 2296.

22. Weiqi Zhang, Haiyan Xu. Tailoring the RNAi efficiency of polyplexes. Bioengineered. 2014, 5, 152.

23. Tao Wang, Weiqi Zhang, Wanshu Chen, Jie Meng, Qinglin Hu, Jian Liu, Tao Wen, Bing Han, Haiyan Xu. As4S4 nanoparticles promote effective terminal erythropoiesis in bone marrow mononuclear cells from patients with myelodysplastic syndromes. Nano Today, 2023, 52, 101965.
24. Shilin Xu, Meichen Zhang, Xiaocui Fang, Jie Meng, Haiyan Xing, Doudou Yan, Jian Liu, Yanlian Yang, Tao Wen, Weiqi Zhang, Jianxiang Wang, Chen Wang, Haiyan Xu. A novel CD123-targeted therapeutic peptide loaded by micellar delivery system combats refractory acute myeloid leukemia. Journal of Hematology & Oncology. 2021, 14, 193.
25. Seung Koo Lee, Myung Shin Han, Weiqi Zhang, Ching-Hsuan Tung. Multilayered activatable nanoprobe for ultra-bright tumor imaging. Macromolecular Bioscience. 2019, 19, 1900260.
26. Baoji Du, Weiqi Zhang, Ching-Hsuan Tung. A multiresponsive nanohybrid to enhance the lysosomal delivery of oxygen and photosensitizers. Chemistry–A European Journal. 2019, 25, 12801.
27. Hua Guo, Harikrishna Kommidi, Uday B Maachani, Julia C Voronina, Weiqi Zhang, Rajiv S Magge, Jana Ivanidze, Amy P Wu, Mark M Souweidane, Omer Aras, Richard Ting. An [18F]-positron emitting fluorophore allows safe evaluation of small molecule distribution in the CSF, CSF Fistulas, and CNS device placement. Molecular Pharmaceutics. 2019, 16, 3636.
28. Hua Guo, Harikrishna Kommidi, Yogindra Vedvyas, Jaclyn E McCloskey, Weiqi Zhang, Nandi Chen, Fuad Nurili, Amy P Wu, Haluk B Sayman, Oguz Akin, Erik A Rodriguez, Omer Aras, Moonsoo M Jin, Richard Ting. A fluorescent, [18F]-positron-emitting agent for imaging prostate-specific membrane antigen allows genetic reporting in adoptively transferred, genetically modified cells. ACS Chemical Biology. 2019, 14, 1449.
29. Baoji Du, Weiqi Zhang, Ching-Hsuan Tung. Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy. Chemical Communications. 2019, 55, 5926.
30. Tae Sup Lee, Young Kim, Weiqi Zhang, In Ho Song, Ching-Hsuan Tung. Facile metabolic glycan labeling strategy for exosome tracking. Biochim Biophys Acta. 2018, 1862, 1091.
31. Wenjuan Ma, Jian Liu, Jundan Xie, Xiuyan Zhang, Haixia Zhou, Hong Yao, Weiqi Zhang, Dawei Guo, Lingying Zhu, Lun Xiao, Depei Wu, Haiyan Xu, Suning Chen, Yun Zhao. Modulating the growth and imatinib sensitivity of chronic myeloid leukemia stem/progenitor cells with pullulan/microRNA nanoparticles in vitro. Journal of Biomedical Nanotechnology. 2015, 11, 1961.
32. Jie Meng, Yinglu Ji, Jian Liu, Xuelian Cheng, Hua Guo, Weiqi Zhang, Xiaochun Wu, Haiyan Xu. Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice, Nanotoxicology, 2014, 8, 686.
33. Jie Meng, Xuelian Cheng, Jian Liu, Weiqi Zhang, Xiaojin Li, Hua Kong, Haiyan Xu. Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation. PLoS one, 2012, 7, e38995.
34. Man Yang, Jie Meng, Xuelian Cheng, Jing Lei, Hua Guo, Weiqi Zhang, Hua Kong, Haiyan Xu. Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis. Theranostics, 2012, 2, 258.
35. Jie Meng, Man Yang, Fumin Jia, Hua Kong, Weiqi Zhang, Chaoying Wang, Jianmin Xing, Sishen Xie, Haiyan Xu. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity. Nanotechnology, 2010, 21, 145104.