李雋，籍貫河北，本科畢業(yè)于北京大學(xué)醫學(xué)部基礎醫學(xué)專(zhuān)業(yè)，2010年在美國Texas A&M University 獲得生物化學(xué)與生物物理博士學(xué)位。2010-2018年師從于哈佛醫學(xué)院遺傳系David Sinclair教授進(jìn)行博士后研究。2018年8月至今，受聘于中國醫學(xué)科學(xué)院基礎醫學(xué)研究所/北京協(xié)和醫學(xué)院基礎醫學(xué)院，目前擔任生物化學(xué)與分子生物學(xué)系課題組長(cháng)，研究員。2018年入選中國醫學(xué)科學(xué)院/北京協(xié)和醫學(xué)院 “高端科技人才”引進(jìn)專(zhuān)項支持計劃“優(yōu)秀青年人才”。

本課題組主要從事衰老的分子機制和抗衰老干預方法的研究和應用。具體研究方向包括：

     （1）NAD代謝對衰老進(jìn)程的調控

     （2）細胞衰老的發(fā)生機制及調控

     （3）DNA損傷/修復對細胞及機體水平衰老的影響和調控

      目前課題組成員包括助研1名，技術(shù)員2名 ，實(shí)驗室管理員1人，碩士研究生5人，博士生2人。計劃招聘助理研究員1名（研究崗），博士后1名, 同時(shí)也歡迎對衰老研究有興趣的本科生或研究生進(jìn)行交換培養或實(shí)習。

      聯(lián)系方式：北京市東城區東單三條5號，老科研樓 429房間，郵編 100005，Email：jun_li@ibms.pumc.edu.cn

      代表性論文：

1.    Qing Tan, Xiaoqian Zhang, Shuxiang Li, Wenbin Liu, Jiaqi Yan, Siqi Wang, Feng Cui, Dan Li, Jun Li*. DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis. Free Radical Blology and Medicine. 207 (2023) 32-44.

2.    Feng Cui, Xueying Han, Xiaoqian Zhang, Siqi Wang, Na Liang, Qing Tan,Wuga Sha, Jun Li*. ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction. Cells. 2023, 12(1), 145.

3.    Qing Tan, Na Liang, Xiaoqian Zhang, Jun Li*. Dynamic aging: channeled through microenvironment. Frontiers in Physiology. 2021, 12:702276.

4.    Evandro F. Fang, Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, Johannes Frank, Jing Liao, Huachun Zou, Ninie Y. Wang, Jing Wu, Xiaoting Liu, Tao Li, Yuan Fang, Zhangming Niu, Guang Yang, Jiangshui Hong, Qian Wang, Guobing Chen, Jun Li, Hou-Zao Chen, Lin Kang, Huanxing Su, Brian C. Gilmour, Xinqiang Zhu, Hong Jiang, Na He, Jun Tao, Sean Xiao Leng, Tanjun Tong, Jean Woo*. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks, Ageing Research Reviews, 2020;101174,

5.    Emma Bolderson*, Joshua T Burgess, Jun Li, Neha S Gandhi, Didier Boucher, Laura V Croft, Samuel Beard, Jennifer J Plowman, Amila Suraweera, Mark N Adams, Ali Naqi, Shu-Dong Zhang, David A Sinclair, Kenneth J O'Byrne, Derek J Richard*. Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Nature Communication. 2019;10(1):5501.

6.    Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J.Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn and David A. Sinclair*. A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging. Science, 2017, 355(6331): 1312-1317.

7.    Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Hilde Nilsen, Vilhelm A. Bohr*. NAD+ replenishment significantly improves outcomes in Ataxia telangiectasia models via mitophagy and DNA repair, Cell Metabolism, 2016, 24(4): 566-581.

8.    Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA*. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism, Cell cycle. 2013,12(14): 2233-2240.

9.    Hubbard, P., Gomes, A., Dai, H., Li, J., Case, A., Considine, T., Riera, T., Lee, J., Yen, ES, Lamming, D., Pentelute, B., Schuman, E., Stevens, L., Ling, A., Armour, S., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S., Blum, C., Disch, J., Ng, PY., Howitz, K., Hamaro, Y., Moss, J., Perni, R., Ellis, J., Vlasuk, G. and Sinclair, D.A*. Evidence for a common mechanism of Sirt1 activation by small molecules. Science, 2013, 339(6124): 1216-1219.

10. Jun Li and Paul Fitzpatrick*. Regulation of Phenylalanine Hydroxylase: Conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry, Arch Biochem Biophys. 2013, 535(2): 115-119.

11. Jun Li, Udayar Ilangovan, Susan Daubner, Andy Hinck, Paul Fitzpatrick*. Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase. Arch Biochem Biophys. 2011, 505(2): 250-255.

12. Jun Li, Larry Dangott, and Paul Fitzpatrick*. Regulation of phenylalanine Hydroxylase: Conformational changes upon phenylalanine binding detected by H/D exchange and mass spectrometry. Biochemistry. 2010, 49(15): 3327-3335.

13. Jun Li and Paul Fitzpatrick*. Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad. Arch Biochem Biophys. 2008, 475: 164-168.