王晨軒，研究員，博士生導師。1986年生于北京。中國醫學(xué)科學(xué)院基礎醫學(xué)研究所/北京協(xié)和醫學(xué)院基礎學(xué)院，生物物理與結構生物學(xué)系課題組長(cháng)，院校準長(cháng)聘教職系列，中國生物物理學(xué)會(huì )納米生物學(xué)分  會(huì )優(yōu)秀青年學(xué)者（2023年）。在Sci Adv, PNAS, ACS Cent Sci, JACS, Nano Lett等國際期刊上發(fā)表論文60余篇，獲得國家專(zhuān)利授權16項。當前研究方向為疾病相關(guān)蛋白質(zhì)折疊、組裝、相變與調控。課題 組隸屬于重大疾病共性機制研究全國重點(diǎn)實(shí)驗室。實(shí)驗室有副研究員2人，博士與碩士研究生8人。主講八年制與研究生課《生物物理學(xué)》，參與《納米醫學(xué)概論》、《化學(xué)生物學(xué)》、《生理學(xué)的物理分 析》等研究生課教學(xué)任務(wù)。

聯(lián)系方式

北京市東城區東單三條5號，老科研樓 461，郵編 100005

Email：wangcx@ibms.pumc.edu.cn

教育及工作經(jīng)歷

2004-2008年，蘭州大學(xué)國家理科化學(xué)基地班，本科。

2008-2013年，中國科學(xué)院國家納米科學(xué)中心與清華大學(xué)化學(xué)系聯(lián)合培養研究生，物理化學(xué)專(zhuān)業(yè)。導師王琛研究員、楊延蓮研究員、李艷梅教授。研究方向：淀粉樣蛋白折疊結構的研究及多肽-藥物相互作用。2013年獲清華大學(xué)理學(xué)博士學(xué)位。

2010年，丹麥奧胡斯大學(xué)多學(xué)科交叉納米中心訪(fǎng)問(wèn)學(xué)者，合作導師董明東教授。

2013-2018年，美國威斯康星大學(xué)麥迪遜校區化學(xué)系，化學(xué)與生物工程系博士后。合作導師美國工程院院士Nicholas L. Abbott教授，美國科學(xué)院院士Samuel H. Gellman教授。研究方向：多肽折疊結構與單分子力學(xué)研究。

2018至今，中國醫學(xué)科學(xué)院基礎醫學(xué)研究所/北京協(xié)和醫學(xué)院基礎學(xué)院生物物理與結構生物學(xué)系，課題組長(cháng)。歷任副研究員、碩士生導師、研究員、博士生導師。

研究方向：疾病相關(guān)蛋白質(zhì)組裝與調控

蛋白質(zhì)的正確折疊與組裝是維持人體生理機能的必需。肽鏈通過(guò)精密地調控分子間相互作用自組裝形成有序三維分子結構，進(jìn)一步組裝、聚集、相分離，形成執行生理功能的分子機器與無(wú)膜細胞器。蛋白質(zhì)組裝穩態(tài)失衡是一系列退行性疾病共同的病理生理基礎。研究蛋白質(zhì)組裝過(guò)程與結構，認識自組裝過(guò)程中的分子間相互作用的本質(zhì)與規律，實(shí)現對自組裝過(guò)程與功能的有效調控對蛋白質(zhì)組裝相關(guān)疾病的預防和治療有重要意義，從經(jīng)典藥物治療到相關(guān)新型藥物治療的興起，從微觀(guān)層面對發(fā)病分子機理的闡述到宏觀(guān)層面治療模式的創(chuàng )新，新的認識將在未來(lái)改變相關(guān)疾病的診治模式，為患者改善預后帶來(lái)新的機遇。

課題組遵循“認識組裝-調控組裝-利用組裝”的研究思路，發(fā)展掃描隧道顯微術(shù)、原子力探針顯微術(shù)、核磁共振波譜技術(shù)、X-射線(xiàn)單晶衍射、光散射等新穎的物理、物理化學(xué)方法用于生物大分子的結構測定，在單分子水平理解與重大疾病發(fā)生、發(fā)展密切相關(guān)的蛋白、多肽的折疊、組裝結構和過(guò)程，認識蛋白、多肽折疊組裝過(guò)程中的相互作用本質(zhì)與調控規律。

當前，課題組開(kāi)展的研究課題包括：

（1）蛋白質(zhì)折疊、組裝與分子識別的物理化學(xué)機制（Sci Adv, 2023; ACS Cent Sci, 2023; Nano Lett, 2023; Mater Today Phys, 2024; J Am Chem Soc, 2017; Nature, 2015）

（2）蛋白質(zhì)折疊與組裝調控的生物學(xué)與醫學(xué)應用：靶向夏科-萊登晶體的藥物干預及其在慢性鼻鼻竇炎治療中的應用（Nano Lett, 2022）

（3）藥物的選擇性寡聚化識別淀粉樣蛋白組裝體的分子機制以及生物學(xué)功能（Sci Adv, 2020）

課題組導師團隊

招生要求：

課題組開(kāi)展多學(xué)科交叉研究，目前實(shí)驗室成員的教育背景涵蓋了生物學(xué)、化學(xué)、藥學(xué)、物理、基礎醫學(xué)、檢驗醫學(xué)、生物信息學(xué)、化學(xué)工程、材料科學(xué)、法醫。歡迎生物學(xué)、生物技術(shù)、藥學(xué)、基礎醫學(xué)、檢驗醫學(xué)、生物工程、生物信息學(xué)及相關(guān)專(zhuān)業(yè)的學(xué)生報考。

招生要求：（1）本科專(zhuān)業(yè)主干課成績(jì)優(yōu)秀；（2）熱愛(ài)科學(xué)研究與基礎研究，對未知領(lǐng)域有強烈好奇心、獻身精神；（3）有團隊合作精神；（4）中文表達與寫(xiě)作能力優(yōu)異，良好的普通話(huà)書(shū)面語(yǔ)溝通、交流與演講能力；（5）英文讀寫(xiě)能力合格，全國大學(xué)英語(yǔ)六級考試成績(jì)及格。

課題組掠影

在讀學(xué)生

已畢業(yè)學(xué)生

課題組歷年發(fā)表論文

2024 Publications

64. Zhongyi Jian#, Ruonan Wang#, Shanshan Mo, Zhun Deng, Shuyuan Li, Zhenyan Li, Mingzhan Wang, Yanlian Yang, Chen Wang, Wenbo Zhang, Lanlan Yu*, Chenxuan Wang*, Structural evolution of the conformational ensembles in peptide fibrillar aggregates, Materials Today Physics, 2024, 44, 101437, DOI: 10.1016/j.mtphys.2024.101437.

2023 Publications

63. Wenbo Zhang#, Ruonan Wang#, Mingwei Liu#, Shucong Li, Asher E. Vokoun, Weichen Deng, Robert L. Dupont, Feiyi Zhang, Shuyuan Li, Yang Wang, Zhenyu Liu, Yongfang Zheng, Shuli Liu, Yanlian Yang, Chen Wang, Lanlan Yu*, Yuxing Yao, Xiaoguang Wang*, Chenxuan Wang*, Single-molecule visualization determines conformational sub-state ensembles in β-sheet-rich peptide fibrils, Science Advances, 2023, 9(27), eadg794, DOI: 10.1126/sciadv.adg7943.

62. Lanlan Yu#, Ruonan Wang#, Shucong Li, Ufuoma I. Kara, Eric C. Boerner, Boyuan Chen, Feiyi Zhang, Zhongyi Jian, Shuyuan Li, Mingwei Liu, Yang Wang, Shuli Liu, Yanlian Yang, Chen Wang, Wenbo Zhang*, Yuxing Yao, Xiaoguang Wang*, Chenxuan Wang*, Experimental insights into conformational ensembles of assembled sheet peptides, ACS Central Science, 2023, 9(7), 1480–1487, DOI: 10.1021/acscentsci.3c00230.

61. Wenbo Zhang#, Mingwei Liu#, Yang Wang#, Xin Wang, Ruonan Wang, Shuyuan Li, Lanlan Yu, Feiyi Zhang, Chenxuan Wang*, b-Sheet assembly translates conservative single-site mutation into a perturbation in macroscopic structure, Nano Letters, 2023, 23(6), 2370-2378, DOI: 10.1021/acs.nanolett.3c00311.

60. Chenxuan Wang*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical organization of supramolecular systems: from fundamentals to biomedical applications, volume II, Frontiers in Bioengineering and Biotechnology, 2023, 11, 1177799, DOI: 10.3389/fbioe.2023.1177799.

2022 Publications

59. Meichen Zhang#, Yangyang Ge#, Shilin Xu, Xiaocui Fang, Jie Meng, Lanlan Yu, Chenxuan Wang, Jian Liu, Tao Wen, Yanlian Yang, Chen Wang*, Haiyan Xu*, Nanomicelles co-loading CXCR4 antagonist and doxorubicin combat the refractory acute myeloid leukemia, Pharmacological Research, 2022, 185, 106503, DOI: 10.1016/j.phrs.2022.106503.

58. Lanlan Yu#, Ruonan Wang#, Tao Wen#, Lei Liu, Tao Wang, Shuli Liu, Haiyan Xu*, Chenxuan Wang*, Peptide binder with high-affinity for the SARS-CoV-2 spike receptor-binding domain, ACS Applied Materials & Interfaces, 2022, 14(25), 28527–28536, DOI: 10.1021/acsami.2c03707.

57. Yan Zhao#, Shanshan Mo#, Lanlan Yu#, Xiaolu Li, Yun Hao, Wenbo Zhang, Qi Zhang, Ping Wang, Xiangdong Wang*, Chenxuan Wang*, Luo Zhang*, Crystalline state determines the potency of galectin-10 protein assembly to induce inflammation, Nano Letters, 2022, 22(6), 2350-2357, DOI: 10.1021/acs.nanolett.1c04817.

56. Feiyi Zhang#, Lanlan Yu#, Zhun Deng, Shuli Liu, Chenxuan Wang*, Lei Liu*, Composition-dependent wettability of nature-inspired homo poly(amino acid) coating and its influences on bacterial adhesion, European Polymer Journal, 2022, 168, 111127, DOI: 10.1016/j.eurpolymj.2022.111127.

55. Wenbo Zhang#, Mingwei Liu#, Lanlan Yu#, Shanshan Mo, Zhun Deng, Shuli Liu, Yanlian Yang, Chen Wang, Chenxuan Wang*, Perturbation effect of single polar group substitution on the self-association of amphiphilic peptide helices, Journal of Colloid and Interface Science, 2022, 610, 1005-1014, DOI: 10.1016/j.jcis.2021.11.154.

54. Zhichao Lou#, Qiuyi Wang, Xiaodi Zhou, Ufuoma I. Kara, Rajdeep S. Mamtani, Hualiang Lv*, Meng Zhang, Zhihong Yang, Yanjun Li, Chenxuan Wang*, Solomon Adera*, Xiaoguang Wang*, An angle-insensitive electromagnetic absorber enabling a wideband absorption, Journal of Materials Science & Technology, 2022, 113, 33-39, DOI: 10.1016/j.jmst.2021.11.007.

2021 Publications

53. Wenbo Zhang#, Mingwei Liu#, Robert L. Dupont, Kai Huang, Lanlan Yu, Shuli Liu, Xiaoguang Wang*, Chenxuan Wang*, Conservation and identity selection of cationic residues flanking the hydrophobic regions in intermediate filament superfamily, Frontiers in Chemistry, 2021, 9, 752630, doi: 10.3389/fchem.2021.752630.

52. Feiyi Zhang#, Lanlan Yu#, Wenbo Zhang#, Lei Liu*, Chenxuan Wang*, A minireview on the perturbation effects of polar groups to direct nanoscale hydrophobic interaction and amphiphilic peptide assembly, RSC Advances, 2021, 11, 28667-28673, doi: 10.1039/d1ra05463e.

51. Chenxuan Wang#*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical organization of supramolecular systems: from fundamentals to biomedical applications, Frontiers in Bioengineering and Biotechnology, 2021, 9, 754980, doi: 10.3389/fbioe.2021.754980.

50. Lanlan Yu#, Zhun Deng#, Wenbo Zhang, Shuli Liu, Feiyi Zhang, Jianjian Zhou, Chunhua Ma, Chenxuan Wang*, Opposite Regulatory Effects of immobilized cations on the folding versus assembly of melittin, Frontiers in Chemistry, 2021, 9, 685947, doi: 10.3389/fchem.2021.685947.

49. Yan Zhao#, Xiaolu Li#, Wenbo Zhang#, Lanlan Yu#, Yang Wang, Zhun Deng, Mingwei Liu, Shanshan Mo, Ruonan Wang, Jinming Zhao, Shuli Liu, Yun Hao, Xiangdong Wang, Tianjiao Ji*, Luo Zhang*, Chenxuan Wang*, Trends in the biological functions and medical applications of extracellular vesicles and analogues, Acta Pharmaceutica Sinica B, 2021, 11(8), 2114-2135, doi: 10.1016/j.apsb.2021.03.012.

48. Lanlan Yu#, Yongfang Zheng, Xiaocui Fang, Yimin Zou, Chenxuan Wang*, Yanlian Yang*, Chen Wang*, Composition-dependent multivalency of peptide-peptide interactions revealed by tryptophan-scanning mutagenesis, Journal of Peptide Science, 2021, 27, e3310, doi: 10.1002/psc.3310.

47. Shan He#, Xinyue He, Lei Liu, Wenbo Zhang, Lanlan Yu, Zhun Deng, Zhang Feiyi, Shanshan Mo, Yue Fan, Xinyue Zhao, Lun Wang, Chenxuan Wang*, Shuyang Zhang*, The structural understanding of transthyretin misfolding and the inspired drug approaches for the treatment of heart failure associated with transthyretin amyloidosis, Frontiers in Pharmacology, 2021, 12, 628184, doi: 10.3389/fphar.2021.628184.

46. Chenxuan Wang#, Naomi A. Biok, Karthik Nayani, Xiaoguang Wang, Hongseung Yeon, Chi-Kuen Derek Ma, Samuel H. Gellman*, Nicholas L. Abbott*, Cationic side chain identity directs the hydrophobically driven self-assembly of amphiphilic β-peptides in aqueous solution, Langmuir, 2021, 37, 3288-3298, doi: 10.1021/acs.langmuir.0c03255.

2020 Publications

45. Lanlan Yu#, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang*, Yanlian Yang, Chen Wang, Chenxuan Wang*, Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, Science Advances, 2020, 6(32), eabc1449, doi: 10.1126/sciadv.abc1449.

44. Wenbo Zhang#, Shanshan Mo#, Mingwei Liu#, Lei Liu, Lanlan Yu*,   Chenxuan Wang*, Rationally designed protein building blocks for programmable hierarchical architectures, Frontiers in Chemistry, 2020, 8, 587975, doi: 10.3389/fchem.2020.587975.

43. Lanlan Yu#, Zhun Deng#, Lei Liu, Wenbo Zhang*, Chenxuan Wang*, Plant-derived nanovesicles: a novel form of nanomedicine, Frontiers in Bioengineering and Biotechnology, 2020, 8, 584391, doi: 10.3389/fbioe.2020.584391.

42. Wenbo Zhang#, Lanlan Yu, Tianjiao Ji*, Chenxuan Wang*, Tumor microenvironment-responsive peptide based supramolecular drug delivery system, Frontiers in Chemistry, 2020, 8, 549, doi: 10.3389/fchem.2020.00549.

41. Hongseung Yeon#, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Influence of immobilized cations on the thermodynamic signature of hydrophobic interactions at chemically heterogeneous surfaces, Molecular Systems Design and Engineering, 2020, 5(4), 835-846, doi: 10.1039/d0me00016g.

40. Qize Xuan#, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang*, Yibing Wang*, Ping Wang, Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity, Chemical Communications, 2020, 56(11), 1633-1636, doi: 10.1039/c9cc08671d.

2019 Publications

39. Naomi A. Biok#, Alexander D. Passow, Chenxuan Wang, Craig A. Bingman, Nicholas L. Abbott*, Samuel H. Gellman*, Retention of coiled-coil dimer formation in the absence of ion pairing at positions flanking the hydrophobic core, Biochemistry, 2019, 58(48), 4821-4826, doi: 10.1021/acs.biochem.9b00668.

38. Chenxuan Wang#, Travis Nelson, Dayue Chen, Joseph Christopher Ellis, Nicholas L. Abbott*, Understanding Lipopolysaccharide Aggregation and its Influence on Activation of Factor C, Journal of Colloid and Interface Science, 2019, 552, 540-553, doi: 10.1016/j.jcis.2019.05.013.

37. Xiaoyun Li#, Zhu Liang#, Jianchao Du#, Zhiqing Wang, Song Mei, Zhiqing Li, Yan Zhao, Dandan Zhao, Yiming Ma, Jun Ye, Jiantao Xu, Yu Zhao, Jiahui Chang, Yuhao Qin, Lanlan Yu, Chenxuan Wang*, Chengyu Jiang*, Herbal decoctosome is a novel form of medicine, Science China-Life Sciences, 2019, 62(3), 333-348, doi: 10.1007/s11427-018-9508-0.

36. Zhihui Yao#, Brian P. Cary, Craig A. Bingman, Chenxuan Wang, Dale F. Kreitler, Kenneth A. Satyshur, Katrina T. Forest, Samuel H. Gellman*, Use of a stereochemical strategy to probe the mechanism of phenol-soluble modulin alpha 3 toxicity, Journal of the American Chemical Society, 2019, 141(19), 7660-7664, doi: 10.1021/jacs.9b00349.

35. Qunxing Huang#, Qiong Zhao, Jiaxi Peng, Ooolalla Yu, Chenxuan Wang, Yimin Zou, Yanlei Su, Ling Zhu*, Chen Wang*, Yanlian Yang*, Peptide-polyphenol (KLVFF/EGCG) binary modulators for inhibiting aggregation and neurotoxicity of amyloid-beta peptide, ACS Omega, 2019, 4(2), 4233-4242, doi: 10.1021/acsomega.8b02797.

2018 Publications

34. Reza Abbasi#, Chenxuan Wang, Yiqun Bai, Nicholas L. Abbott*, Phosphorylation status of peptide monolayers modulates hydrogen bonding and orientations of nematic liquid crystals, Liquid Crystal, 2018, 45 (13-15), 2253-2268, doi: 10.1080/02678292.2018.1509389.

2017 Publications

33. Chenxuan Wang#, C. Derek Ma, Hongseung Yeon, Xiaoguang Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Nonadditive interactions mediated by water at chemically heterogeneous surfaces: nonionic polar groups and hydrophobic interactions, Journal of the American Chemical Society, 2017, 139(51), 18536-18544, doi: 10.1021/jacs.7b08367.

32. Hongseung Yeon#, Chenxuan Wang, Reid C. Van Lehn, Nicholas L. Abbott*, Influence of order within nonpolar monolayers on hydrophobic interactions, Langmuir, 2017, 33(19), 4628-4637, doi: 10.1021/acs.langmuir.7b00226.

31. Timothy J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Redox-triggered mixing and demixing of surfactants within assemblies formed in solution and at surfaces, Journal of Colloid and Interface Science, 2017, 502, 122-133, doi: 10.1016/j.jcis.2017.04.052.

30. Aihua Yang#, Chenxuan Wang, Baomin Song, Wendi Zhang, Yuanyuan Guo, Rong Yang, Guangjun Nie, Yanlian Yang*, Chen Wang*, Attenuation of beta-amyloid toxicity in vitro and in vivo by accelerated aggregation, Neuroscience Bulletin, 2017, 33(4), 405-412, doi: 10.1007/s12264-017-0144-z.

2016 Publications

29. C. Derek Ma#, Claribel Acevedo-Vélez, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Interaction of the hydrophobic tip of an atomic force microscope with oligopeptides immobilized using short and long tethers, Langmuir, 2016, 32(12), 2985-2995, doi: 10.1021/acs.langmuir.5b04618.

28. Juan Liu#, Tuo Wei, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowei Ma, Xingjie Liang*, Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance, Biomaterials, 2016, 91, 44-56, doi: 10.1016/j.biomaterials.2016.03.013.

2015 Publications

27. C. Derek Ma#, Chenxuan Wang, Claribel Acevedo-Vélez, Samuel H. Gellman*, Nicholas L. Abbott*, Modulation of hydrophobic interactions by proximally immobilized ions, Nature, 2015, 517(7534), 347-U443 doi: 10.1038/nature14018.

26. Yanmei Wang#, Chenxuan Wang#, Zhiqiang Cheng, Dongdong Zhang, Shaopeng Li, Lusheng Song, Wenfei Zhou, Mo Yang, Zhiyou Wang, Zheng Zheng, Baohang Han, Chen Wang*, Yanlian Yang*, Jinsong Zhu*, SPRi determination of inter-peptide interaction by using 3D supramolecular co-assembly polyrotaxane film, Biosensors and Bioelectronics, 2015, 66, 38-44, doi: 10.1016/j.bios.2014.11.025.

25. Timothy J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Influence of self-assembling redox mediators on charge transfer at hydrophobic electrodes, Langmuir, 2015, 31(39), 10638-10648, doi: 10.1021/acs.langmuir.5b02212.

24. Yang Sun#, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo, Dangsheng Li, Bo Li, Qihan Li, Nanshan Zhong, Chen Wang, Josef M. Penninger, Chengyu Jiang*, Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice, Particle and Fibre Toxicology, 2015, 12, 4, doi: 10.1186/s12989-015-0080-x.

2014 Publications

23. Yiqun Bai#, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott*, Liquid crystals anchored on mixed monolayers of chiral versus achiral molecules: continuous change in orientation as a function of enantiomeric excess, Angewandte Chemie International Edition, 2014, 53 (31), 8079-8083, doi: 10.1002/anie.201402770.

22. Huiwen Du#, Denghua Li, Yibin Wang, Chenxuan Wang, Ping Li, Yanlian Yang*, Chen Wang*, Peptide-assisted directional adsorption of purple membrane at the liquid-solid interface, Journal of Physical Chemistry C, 2014, 118 (51), 29770-29776, doi: 10.1021/jp5077017.

2013 Publications

21. Min Zhang#, Xiaobo Mao, Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang*, Wei Liang*, Chen Wang*, The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr), Biomaterials, 2013, 34 (4), 1383-1390, doi: 10.1016/j.biomaterials.2012.10.067.

20. Min Zhang#, Xiaobo Mao, Yue Yu, Chenxuan Wang, Yanlian Yang*, Chen Wang*, Nanomaterials for reducing amyloid cytotoxicity, Advanced Materials, 2013, 25(28), 3780-3801, doi: 10.1002/adma.201301210.

19. Huiwen Du#, Denghua Li, Yibing Wang, Chenxuan Wang, Dongdong Zhang, Yanlian Yang*, Chen Wang*, Determination of the surface charge density and temperature dependence of purple membrane by electric force microscopy, Journal of Physical Chemistry B, 2013, 117(34), 9895-9899, doi: 10.1021/jp403075w.

18. Ting Zhou#, Axel Llizo, Ping Li, Chenxuan Wang, Yuanyuan Guo, Mingqi Ao, Linling Bai, Chen Wang*, Yanlian Yang*, Guiying Xu*, High transfection efficiency of homogeneous DNA nanoparticles induced by imidazolium gemini surfactant as nonviral vector, Journal of Physical Chemistry C, 2013, 117(50), 26573-26581, doi: 10.1021/jp4061363.

2012 Publications

17. Chenxuan Wang#, Aihua Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang*, Chen Wang*, Observation of molecular inhibition and binding structures of amyloid peptides, Nanoscale, 2012, 4(6), 1895-1909, doi: 10.1039/c2nr11508e.

16. Yuanyuan Guo#, Chenxuan Wang, Jingfei Hou, Aihua Yang, Xuemei Zhang, Yibing Wang, Min Zhang, Yanlian Yang*, Chen Wang*, Odd-even sequence effect of surface-mediated peptide assemblies observed by scanning tunneling microscopy, Chinese Journal of Chemistry, 2012, 30 (9), 1987-1991, doi: 10.1002/cjoc.201200656.

15. Jie Song#, Menglin Chen, Viduthalai Regina, Chenxuan Wang, Rikke Meyer, Erqing Xie, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Safe and effective Ag nanoparticles immobilized antimicrobial nanononwovens, Advanced Engineering Materials, 2012, 14(5), B240-B246, doi: 10.1002/adem.201180085.

14. Peng Liu#, Shuai Zhang, Meisha Chen, Qian Liu, Chenxuan Wang, Chen Wang, Yanmei Li*, Flemming Besenbacher, Mingdong Dong*, Co-assembly of human islet amyloid polypeptide (hIAPP)/insulin, Chemical Communications, 2012, 48(2), 191-193, doi: 10.1039/c1cc14285b.

2011 Publications

13. Xiaobo Mao#, Chenxuan Wang#, Xingkui Wu, Lei Liu, Lan Zhang, Lin Niu, Yanlian Yang*, Chen Wang*, Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies, Proceedings of the National Academy of Sciences of the USA, 2011, 108(49), 19605-19610, doi: 10.1073/pnas.1102971108.

12. Chenxuan Wang#, Xiaobo Mao#, Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibin Wang, Yanlian Yang*, Chen Wang*, Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy, Chemical Communications, 2011, 47(38), 10638-10640, doi: 10.1039/c1cc12380g.

11. Xiaobo Mao#, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Molecular level studies on binding modes of labeling molecules with polyalanine peptides, Nanoscale, 2011, 3(4), 1592-1599, doi: 10.1039/c0nr00782j.

10. Xiaobo Mao#, Yuanyuan Guo, Chenxuan Wang, Min Zhang, Xiaojing Ma, Lei Liu, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy, ACS Chemical Neuroscience, 2011, 2(6), 281-287, doi: 10.1021/cn200006h.

9. Zengguang Cheng#, Qiaoyu Zhou, Chenxuan Wang, Qiang Li, Chen Wang, Ying Fang*, Toward intrinsic graphene surfaces: a systematic study on thermal annealing and wet-chemical treatment of SiO2-supported graphene devices, Nano Letter, 2011, 11(2), 767-771, doi: 10.1021/nl103977d.

8. Jie Song#, Menglin Chen, Mikkel Buster Olesen, Chenxuan Wang, Rasmus Havelund, Qiang Li, Erqing Xie, Rong Yang, Peter Boggild, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Direct electrospinning of Ag/polyvinylpyrrolidone nanocables, Nanoscale, 2011, 3(12), 4966-4971, doi: 10.1039/c1nr10512d.

7. Weiwei He#, Shuai Hou, Xiaobo Mao, Xiaochun Wu*, Yinglu Jin, Jianbo Liu, Xiaona Hu, Ke Zhang, Chenxuan Wang, Yanlian Yang, Qi Wang, Peptide-tailored assembling of Au nanorods, Chemical Communications, 2011, 47(19), 5482-5484, doi: 10.1039/c1cc10394f.

2010 Publications

6. Xiaobo Mao#, Chenxuan Wang, Lei Liu, Xiaojing Ma, Lin Niu, Yanlian Yang*, Chen Wang*, Study on the fine structure of polypeptides at solid-liquid interfaces by scanning tunneling microscopy, Acta Physico-Chimica Sinica, 2010, 26(4), 850-861, doi: 10.3866/PKU.WHXB20100440.

5. Xuemei Zhou#, Hongchao Yang, Chenxuan Wang, Yinfang Cui, Xiaobo Mao, Cong Wang, Yinshu Wang, Gang Liu*, Visible light induced photocatalytic degradation rhodamine B on one-dimensional iron oxide particles, Journal of Physical Chemistry C, 2010, 114(40), 17051-17061, doi: 10.1021/jp103816e.

4. Xiaobo Mao#, Hongchao Yang, Xuemei Zhou, Chenxuan Wang, Yinshu Wang, Yanlian Yang, Chen Wang, Gang Liu*, Straight and Branched Goethite Topology by Oriented Attachment at High pH, Crystal Growth & Design, 2010, 10(2), 504-509, doi: 10.1021/cg900392m.

3. Tao Zhang#, Zengguang Cheng, Yibing Wang, Zhongjun Li, Chenxuan Wang, Yibao Li, Ying Fang*, Self-assembled 1-octadecanethiol monolayers on graphene for mercury detection, Nano Letters, 2010, 10(11), 4738-4741, doi: 10.1021/nl1032556.

2. Hongchao Yang#, Xuemei Zhou, Tengteng Tang, Xiaoying Qi, Chenxuan Wang, Jinyao Lan, Yinshu Wang, Yanlian Yang, Gang Liu*, Anisotropic growth of multi-twinned goethite particles by oriented aggregation, CrystEngComm, 2010, 12(12), 4007-4009, doi: 10.1039/c0ce00437e.

1. Jie Jiang#, Xiaoliang Tang, Wei Dou, Huihui Zhang, Weisheng Liu*, Chenxuan Wang, Jiangrong Zheng, Synthesis and characterization of the ligand based on benzoxazole and its transition metal complexes: DNA-binding and antitumor activity, Journal of Inorganic Biochemistry, 2010, 104(5), 583-591, doi: 10.1016/j.jinorgbio.2010.01.011.

著(zhù)作

Books and Chapters

3. Lanlan Yu#, Yanlian Yang, Chen Wang, Chenxuan Wang*. Peptide Assemblies on Surfaces: A Study Using Scanning Tunneling Microscopy. In: Xuehai Yan (eds) Peptide Self-Assembly and Engineering, 2 Volumes: Fundamentals, Structures, and Applications. 2024, Wiley-VCH, Weinheim, Germany.

2. Wenbo Zhang#, Lanlan Yu, Chenxuan Wang*. Intermolecular interactions and self-assembly of peptide-based nanomaterials against human pathogenic bacteria. In: Haiyan Xu, Ning Gu. (eds) Nanotechnology in regenerative medicine and drug delivery therapy. 2020, Springer, Singapore

1. 王晨軒#，楊延蓮*，王琛*. 《納米生物醫學(xué)光電子學(xué)前沿》第七章《淀粉樣蛋白的結構分析研究進(jìn)展》科學(xué)出版社，2013年，北京

發(fā)明專(zhuān)利

Patents

16. 王晨軒，張文博，王洋，李淑媛. 二甲雙胍及其它含胍化合物在逆轉Gal-10結晶趨勢并緩解相關(guān)疾病中應用。國家發(fā)明專(zhuān)利. 授權公告日2024-03-19, 專(zhuān)利號 ZL202210534642.4

15. 王晨軒，張羅，莫珊珊，王向東，于蘭蘭，趙妍，李小璐，張文博，郝蘊. 多肽在制備治療2型免疫疾病的藥物中的應用。國家發(fā)明專(zhuān)利. 授權公告日2022-08-19, 專(zhuān)利號 ZL202111008545.3

14. 王晨軒，莫珊珊，于蘭蘭，張羅，趙妍，王向東，李小璐，張文博，郝蘊. 用于治療2型免疫疾病的多肽。國家發(fā)明專(zhuān)利. 授權公告日2022-08-19, 專(zhuān)利號 ZL202111008519.0

13. 王晨軒，于蘭蘭，王若楠，許海燕，溫濤. 一種親和肽在制備抗冠狀病毒藥物中的應用。國家發(fā)明專(zhuān)利. 授權公告日2022-07-15, 專(zhuān)利號 ZL202110178816.3

12. 王晨軒，莫珊珊，張羅，趙妍，于蘭蘭，王向東，李小璐，張文博，郝蘊. 靶向夏科-萊登結晶蛋白的多肽及其應用。國家發(fā)明專(zhuān)利. 授權公告日2022-05-03, 專(zhuān)利號 ZL202111008517.1

11. 王晨軒，于蘭蘭，王若楠，許海燕，溫濤. 一種親和肽M5穩定的納米金顆粒及其制備方法和用途。國家發(fā)明專(zhuān)利. 授權公告日2022-04-01, 專(zhuān)利號 ZL202110529881.6

10. 王晨軒，于蘭蘭，王若楠，許海燕，溫濤. 一種新型冠狀病毒主蛋白酶的親和肽M1及其應用。國家發(fā)明專(zhuān)利. 授權公告日2022-02-08, 專(zhuān)利號 ZL202110231722.8

9. 王晨軒，于蘭蘭，王琛，楊延蓮. 一種研究蛋白質(zhì)及藥物-蛋白質(zhì)復合體構象多態(tài)性的方法。國家發(fā)明專(zhuān)利. 授權公告日2021-03-05,專(zhuān)利號 ZL202010070997.3

8. 王晨軒，鄧準，于蘭蘭，張文博，祖瑞涓，鄭明睿. 一種低溶血活性的蜂毒肽及其應用。國家發(fā)明專(zhuān)利. 授權公告日2020-04-28,專(zhuān)利號 ZL201910854177.0

7. 王晨軒，鄧準，于蘭蘭，張文博，祖瑞涓，鄭明睿. 一種蜂毒肽變體及其應用。國家發(fā)明專(zhuān)利. 授權公告日2020-05-12,專(zhuān)利號 ZL201910854956.0

6. 王琛，王晨軒，王艷梅，朱勁松，楊延蓮. 與gp41蛋白結合的多肽、多肽芯片、其制備方法和應用。國家發(fā)明專(zhuān)利. 授權公告日2017-03-01,專(zhuān)利號 ZL201310298420.8

5. 王琛，王晨軒，王艷梅，朱勁松，楊延蓮. 與gp120蛋白結合的多肽、多肽芯片、其制備方法和應用。國家發(fā)明專(zhuān)利. 授權公告日2017-06-27,專(zhuān)利號 ZL201310298450.9

4. 張敏，李平，王晨軒，楊延蓮，王琛. 抑制b淀粉樣蛋白聚集和毒性的多肽抑制劑及其應用。國家發(fā)明專(zhuān)利. 授權公告日2017-12-12,專(zhuān)利號 ZL201310294070.8

3. 王琛，楊?lèi)?ài)華，王晨軒，楊延蓮. 調節b淀粉樣蛋白生理毒性的多肽。國家發(fā)明專(zhuān)利. 授權公告日2017-12-26,專(zhuān)利號 ZL201310421560.X

2. 王琛，張敏，王晨軒，楊延蓮. 一種抑制人胰淀素聚集或毒性的多肽、試劑及其應用。國家發(fā)明專(zhuān)利. 授權公告日2015-11-25,專(zhuān)利號 ZL201210410206.2

1. 王琛，楊延蓮，許海燕，李瀟瑾，張衛奇，孟潔，王晨軒. 一種增強腫瘤細胞對抗腫瘤藥物敏感性的多肽及其應用。國家發(fā)明專(zhuān)利.授權公告日2018-5-4,專(zhuān)利號 ZL201310298419.5