佟偉民

佟偉民課題組簡(jiǎn)介

科研領(lǐng)域與方向：

本課題組是中國醫學(xué)科學(xué)院基礎醫學(xué)研究所特聘教授兼協(xié)和學(xué)者佟偉民教授于2007年回國成立的科研團隊。研究興趣與方向主要有以下三方面：

1、以臨床重大生命健康問(wèn)題為驅動(dòng)、分別從分子、細胞及整體實(shí)驗動(dòng)物水平切入系統性研究表觀(guān)轉錄標記RNA m6A甲基化在腫瘤與神經(jīng)退行性病等重大疾病發(fā)生過(guò)程中的功能與機制。通過(guò)與臨床緊密合作，致力于基礎科研與臨床實(shí)踐的契合與轉化，以達到通過(guò)科研成果幫助臨床醫生解決實(shí)際問(wèn)題的目的。

2、利用不同類(lèi)型的基因工程修飾小鼠，探討蛋白磷酸酶在神經(jīng)發(fā)育與神經(jīng)退行性病變過(guò)程中的作用與機制，同時(shí)構建相應的疾病模型用于篩選神經(jīng)退行性病的藥物。

課題組成員：

佟偉民，博士，教授，博士生導師，課題組長(cháng)

中國醫學(xué)科學(xué)院非人靈長(cháng)類(lèi)醫學(xué)研究中心 副主任

北京協(xié)和醫學(xué)院基礎學(xué)院病理學(xué)系特聘教授、協(xié)和學(xué)者

聯(lián)系電話(huà)：010-69156945

電子郵箱：wmtong(AT)ibms.pumc.edu.cn

牛亞梅，博士，研究員、博士生導師

聯(lián)系電話(huà)：010-69156499

電子郵箱：niuym(AT)ibms.pumc.edu.cn

馬春卉，博士，助理研究員

聯(lián)系電話(huà)：010-69156945

電子郵箱：machunhui(AT)ibms.pumc.edu.cn

李晴，碩士，科研助理

聯(lián)系電話(huà)：010-69156499

電子郵箱：liqing(AT)ibms.pumc.edu.cn

課題組研究生：

博士研究生：潘文琦、陳顏、許月思、李一凡、魏楠

碩士研究生：肖靈鳳、巫喬、付玉潔

聯(lián)合培養研究生：劉思夢(mèng)、沈文平、葉立果

課題組每年招收1-2名碩士、博士研究生，歡迎對本課題組研究方向感興趣的同學(xué)報考。同時(shí)，課題組歡迎本科階段的同學(xué)入組實(shí)習/見(jiàn)習。

主要在研項目：

1. 科技創(chuàng )新2030-重大項目（2021-2026）
2. 中國醫學(xué)科學(xué)院醫學(xué)與健康科技創(chuàng )新工程重大協(xié)同創(chuàng )新項目（2021-2025）
3. 國家重點(diǎn)研發(fā)計劃（2020-2024）

代表性論文: (#共同第一作者；*共同通訊作者)

1. Dong, T., Zhang, Z.Q., Sun, L.H., Zhang, W., Zhu, Z., Lin, L., Yang, L., Lv, A., Liu, C., Li, Q., Yang, R.F., Zhang, X., Niu, Y., Chen, H.Z., Liu, D.P.*, and Tong, W.M.* (2023). Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy. Brain Pathol, e13157.
2. Zhang, Z.W.#, Teng, X.#, Zhao, F.#, Ma, C.#, Zhang, J., Xiao, L.F., Wang, Y., Chang, M., Tian, Y., Li, C., Zhang, Z., Song, S*., Tong, W.M. *, Liu, P*., and Niu, Y.* (2022). METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep 41, 111530.
3. Wang, Z.#, Zhou, Y.#, Bao, L., Li, D., Lv, J., Wang, D., Li, S., Liu, J., Qin, C.*, Tong, W.M.*, and Huang, B.* (2022). Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages. Signal Transduct Target Ther 7, 116.
4. Lyu, C.#, Niu, Y.#, Lai, W., Wang, Y., Wang, Y., Dai, P., Ma, C., Chen, S., Li, Y., Jiang, G., Liang, Z., Ma, W., Gao, Z.*, Tong, W.M.*, and Wang, H.* (2022). Rare and misincorporated DNA N(6)-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells. Cell Discov 8, 39.
5. Gao, C.C.#, Li, M.#, Deng, W.#, Ma, C.H., Chen, Y.S., Sun, Y.Q., Du, T., Liu, Q.L., Li, W.J., Zhang, B., Sun, L., Liu, S.M., Li, F., Qi, F., Qu, Y., Ge, X., Liu, J., Wang, P., Niu, Y., Liang, Z., Zhao, Y.L., Huang, B., Peng, X.Z., Yang, Y.*, Qin, C.*, Tong, W.M.*, and Yang, Y.G.* (2022). Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques. Protein Cell 13, 920-939.
6. Cai, Z., Zhang, Y., Yang, L., Ma, C., Fei, Y., Ding, J., Song, W., Tong, W.M.*, Niu, Y.*, and Li, H.* (2022). ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity. Cell Mol Biol Lett 27, 101.
7. Wu, S.L.#, Zhang, X.#, Chang, M., Huang, C., Qian, J., Li, Q., Yuan, F., Sun, L., Yu, X., Cui, X., Jiang, J., Cui, M., Liu, Y., Wu, H.W., Liang, Z.Y., Wang, X., Niu, Y.*, Tong, W.M.*, and Jin, F.* (2021). Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer. Genomics Proteomics Bioinformatics 19, 64-79.
8. Cai, Z., Niu, Y.*, and Li, H.* (2021). RNA N6-methyladenosine modification, spermatogenesis, and human male infertility. Molecular human reproduction 27.
9. Yang, L., Wu, S., Ma, C., Song, S., Jin, F., Niu, Y.*, and Tong, W.M.* (2020). RNA m(6)A Methylation Regulators Subclassify Luminal Subtype in Breast Cancer. Front Oncol 10, 611191
10. Ma, C.#, Chang, M.#, Lv, H.#, Zhang, Z.W., Zhang, W., He, X., Wu, G., Zhao, S., Zhang, Y., Wang, D., Teng, X., Liu, C., Li, Q., Klungland, A., Niu, Y.*, Song, S.*, and Tong, W.M.* (2018). RNA m(6)A methylation participates in regulation of postnatal development of the mouse cerebellum. Genome Biol 19, 68.
11. Chang, M.#, Lv, H.#, Zhang, W., Ma, C., He, X., Zhao, S., Zhang, Z.W., Zeng, Y.X., Song, S., Niu, Y.*, and Tong, W.M.* (2017). Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain. Open Biol 7.
12. Yang, H., Liu, P., Zhang, J., Peng, X., Lu, Z., Yu, S., Meng, Y., Tong, W.M.*, and Chen, J.* (2016). Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated by miR-193b. Oncogene 35, 3647-3657.
13. Zheng, G.#, Dahl, J.A.#, Niu, Y.#, Fedorcsak, P., Huang, C.M., Li, C.J., V?gb?, C.B., Shi, Y., Wang, W.L., Song, S.H., Lu, Z., Bosmans, R.P., Dai, Q., Hao, Y.J., Yang, X., Zhao, W.M., Tong, W.M., Wang, X.J., Bogdan, F., Furu, K., Fu, Y., Jia, G., Zhao, X., Liu, J., Krokan, H.E., Klungland, A.*, Yang, Y.G.*, and He, C.* (2013). ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell 49, 18-29.
14. Niu, Y., Zhao, X., Wu, Y.S., Li, M.M., Wang, X.J., and Yang, Y.G.* (2013). N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics Proteomics Bioinformatics 11, 8-17.
15. Li, R., Yang, Y.G., Gao, Y., Wang, Z.Q., and Tong, W.M.* (2012). A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell Res 22, 859-872.
16. Guan, J.#, Tong, W.M.#, Ding, W.#, Du, S., Xiao, Z., Han, Q., Zhu, Z., Bao, X., Shi, X., Wu, C., Cao, J., Yang, Y., Ma, W., Li, G., Yao, Y., Gao, J., Wei, J., Dai, J.*, and Wang, R.* (2012). Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model. Biomaterials 33, 1386-1395.

聯(lián)系地址：

中國醫學(xué)科學(xué)院基礎醫學(xué)研究所暨北京協(xié)和醫學(xué)院基礎學(xué)院病理學(xué)系

北京東單三條5號，100005

電話(huà)：010 6915 6499

E-mail：niuym(AT )ibms.pumc.edu.cn