劉雁勇

        劉雁勇，教授，博士生導師，現任中國藥理學(xué)會(huì )抗衰老與老年癡呆專(zhuān)業(yè)委員會(huì )委員，中國老年學(xué)及老年醫學(xué)學(xué)會(huì )老年病學(xué)分會(huì )認知障礙專(zhuān)家委員會(huì )委員，中國研究型醫院學(xué)會(huì )神經(jīng)再生與修復專(zhuān)業(yè)委員會(huì )委員，北京藥理學(xué)會(huì )理事，北京藥理學(xué)會(huì )心腦血管藥理專(zhuān)業(yè)委員會(huì )委員、北京藥理學(xué)會(huì )神經(jīng)精神藥理專(zhuān)業(yè)委員會(huì )常務(wù)委員。
        課題組致力于神經(jīng)精神疾患和腫瘤發(fā)病機制和創(chuàng )新藥物的研究，承擔、參與包括科技重大專(zhuān)項、國家重大科學(xué)研究計劃課題及國家重點(diǎn)基礎研究發(fā)展計劃（973計劃）等課題，已獲5項國家發(fā)明專(zhuān)利授權。申請國際專(zhuān)利1項，目前已獲韓國授權，歐洲、美國、日本專(zhuān)利在審查中。
        課題組具有良好的原代細胞及細胞系培養、動(dòng)物模型建立及行為學(xué)評價(jià)等研究平臺及技術(shù)儲備，研究策略集成藥理、藥化、藥分、藥劑以及生物學(xué)等交叉學(xué)科。

研究興趣與方向：

（1）神經(jīng)精神藥理學(xué)： 關(guān)注抑郁癥、神經(jīng)退行性疾病的發(fā)病機制及創(chuàng )新藥物研究。采用包括蛋白組學(xué)、平面微陣列電極等技術(shù)，重點(diǎn)研究神經(jīng)環(huán)路重建、突觸發(fā)生與疾病發(fā)生的關(guān)系，并探討新干預靶點(diǎn)及創(chuàng )新藥物的設計與評價(jià)。
        （2）腫瘤藥理學(xué)：利用多肽偶聯(lián)、納米等技術(shù)，發(fā)展新型腫瘤分子靶向藥物；關(guān)注精神、免疫等因素在腫瘤發(fā)生、發(fā)展中的作用。

         課題團隊：

左萍萍，研究員，博士生導師（返聘）
        楊楠，副研究員，碩士生導師
        黃薇，助理研究員
        鄭吉，實(shí)習研究員

授權專(zhuān)利：

1. 左萍萍，劉雁勇，楊楠，陳友生，紀超。5-(4-羥基-3-甲氧基苯亞甲基) 羅丹寧在制備治療帕金森氏病藥物中的用途申請日期：2011.3.14，授權日：2014.7.9，ZL 201110060538.8；
        2. 左萍萍，劉雁勇，楊楠，姜堯，張慧豐。一種腫瘤特異性靶向多肽及其應用，申請日期：2013.6.26，授權日：2014.10.8；授權號：ZL 201310258476.0；
        3. 左萍萍，劉雁勇，楊楠，姜堯，張慧豐。一種腫瘤特異性靶向多肽及其應用，申請日期：2013.6.26，授權日：2016.11.2；授權號：ZL 201410246052.7；
        4. 劉雁勇，楊楠，左萍萍。Hsp90抑制肽偶聯(lián)物及其在腫瘤治療中的應用。申請日期：2015.10.20，授權日：2017.09.26，授權號：ZL 201510203194.X；
        5. 劉雁勇，楊楠，左萍萍。5-(4-羥基-3-甲氧基苯亞甲基) 羅丹寧在制備治療預防或治療腦神經(jīng)組織損傷的藥物中的用途申請日期：2015.101.0，授權日：2017.8.16，ZL 2015106513424.
        6. 劉雁勇，楊楠，左萍萍。Hsp90抑制肽偶聯(lián)物及其在腫瘤治療中的應用。韓國授權號：10-1858654，申請日期：2017.09.13；授權日：2018.05.10.

發(fā)表相關(guān)論文：

1.   Wei Huang#, Yuan Liu#, Jun Wang, Xia Yuan, Hong-Wei Jin, Liang-Ren Zhang, Jian-Ting Zhang, Zhen-Ming Liu*, Jing-Rong Cui. Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. European Journal of Medicinal  Chemistry 2018; 157: 887–897. (Co-author)
        2.   Wei Huang#, Xia Yuan, Ting Sun, Shujie Fan, Jun Wang, Quan Zhou, Wei Guo, Fuxiang Ran, Zemei Ge, Huayu Yang, Runtao Li*, Jingrong Cui*. Proteasome inhibitor YSY01A abrogates constitutive STAT3 signaling via down-regulation of Gp130 and JAK2 in human A549 lung cancer cells. Frontiers in Pharmacology 2017; 8(476): 1–10.
        3.  Yao Jiang#, Nan Yang#, Huifeng Zhang, Bo Sun, ChunyingHou, Chao Ji, Ji Zheng, Yanyong Liu*, Pingping Zuo*. Enhanced in vivo Antitumor Efficacy of Dual-functional Peptide-modified Docetaxel Nanoparticles through Tumor Targeting and Hsp90 Inhibition. J Controlled Release 2016；221: 26–36.
        4.  Mingyang Wang#,Yi Zhang#, Lu Feng,Ji Zheng, Shujie Fan, Junya Liu, Nan Yang*, Yanyong Liu*, Pingping Zuo. Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia–reperfusion injury in rats by targeting multiple cellular processes.  Neuropsychiatric Disease and Treatment 2017:13 927–935.
        5.  Mingyang Wang, Lu Feng, Ji Zheng, Junya Liu, Shujie Fan, Jun Zhao, Nan Yang, Yanyong Liu*, Zhanjun Yang*, Caiying Ye*, Pingping Zuo. Improvement of mitochondrial function mediated the neuroprotective effect of 5-(4-hydroxy-3-dimethoxybenzylidene)-2-thioxo-4-thiazolidinone in rats with cerebral ischemia reperfusion injuries. Oncotarget. 2017 Sep 22; 8(37): 61193–61202.
        6.  ChunyingHou, Bo Sun, Yao Jiang, Ji Zheng, Nan Yang, Chao Ji, Zhen Liang, Jiaojiao Shi, Rui Zhang, Yanyong Liu*, Caiying Ye*, PingpingZuo*. MicroRNA-31 inhibits lung adenocarcinoma stem-like cells via down-regulation of MET-PI3K-Akt signaling pathway. Anti-Cancer Agents in Medicinal Chemistry 2016, 16, 501-518.
        7.  Nan Yang#, Yao Jiang#, Huifeng Zhang#, Bo Sun, ChunyingHou, Ji Zheng, Yanyong Liu*, Pingping Zuo*. Active targeting docetaxel-PLA nanoparticles eradicate the circulating lung cancer stem like cells and inhibit the liver metastasis. Mol Pharmaceut 2015, 12, 232?239.
        8.  Bo Sun, Nan Yang, Yao Jiang, Huifeng Zhang, Chunying Hou, Chao Ji, Yanyong Liu*, Pingping Zuo*.Antagomir-1290 suppresses CD133+ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase. Tumor Biol.  2015; 36:6223–6230.
        9.  Zhen Liang#, Nan Yang#, Yao Jiang, Chunying Hou, Ji Zheng, Jiaojiao Shi, Rui Zhang, Dongmei Li, Yanyong Liu*, Pingping Zuo*. Targeting Docetaxel-PLA nanoparticles simultaneously inhibit tumor growth and liver metastases of small cell lung cancer. Int J Pharm. 2015; 494 (1): 337–345.
        10. Nan Yang#, Yan-yong Liu#, Yinglu Ji, Zhili Ren, Jie Meng, Chao Ji, Jian Liu, Ji Zheng, Xiaochun Wu*, Pingping Zuo*, Haiyan Xu*. Motor coordination   dysfunction induced by gold nanorods core /silver shell nanostructures in mice: disruption in mitochondrial transport and neurotransmitter release involved. RSC Advances 2014, 4, 59472- 59480.（Co-author）
        11. Zhang H, N Yang, B. Sun, Y. Jiang, C. Hou, C. Ji, Y. Zhang, Yanyong Liu*, Pingping Zuo*. CD133 positive cells isolated from A549 cell line exhibited high liver metastatic potential. Neoplasma 2014, 61:153-160.
        12. MingyangWang#,Yi Zhang#, Lu Feng,Ji Zheng, Shujie Fan, Junya Liu, Nan Yang*, Yanyong Liu*, Pingping Zuo. Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia–reperfusion injury in rats by targeting multiple cellular processes.  Neuropsychiatric Disease and Treatment 2017:13 927–935.
        13. Mingyang Wang, Lu Feng, Ji Zheng, Junya Liu, Shujie Fan, Jun Zhao, Nan Yang, Yanyong Liu*, Zhanjun Yang*, Caiying Ye*, Pingping Zuo. Improvement of mitochondrial function mediated the neuroprotective effect of 5-(4-hydroxy-3-dimethoxybenzylidene)-2-thioxo-4-thiazolidinone in rats with cerebral ischemia reperfusion injuries. Oncotarget. 2017 May 22. doi: 10.18632/oncotarget.18048.
        14. Dongmei Li#, Ji Zheng#, Mingyang Wang, Lu Feng, Yanyong Liu*, Nan Yang*, Pingping Zuo. Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy. Journal of Ethnopharmacology. 2016; 186：181-188.
        15. Dongmei Li, Ji Zheng, Mingyang Wang, Lu Feng, Yanyong Liu*, Nan Yang*, Pingping Zuo. Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice. Psychiatry Research. 2016; 245:141-147.
        16. Zhili Ren#, Nan Yang#, Chao Ji, Ji Zheng, Tao Wang, Yanyong Liu*, Pingping Zuo*. Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)- thiazolidinone in MPTP induced Parkinsonism model in mice. Neuropharmacology. 2015;93:209-218.
        17. Nan Yang#, Zhili Ren#, Ji Zheng#, Lu Feng, Dongmei Li, Kai Gao, Lianfeng Zhang, Yanyong Liu*, Pingping Zuo. 5-(4-hydroxy-3-dimethoxybenzylidene)-rhodanine (RD-1)-improved mitochondrial function prevents anxiety- and depressive-like states induced by chronic corticosterone injections in mice. Neuropharmacology 2016; 105: 587-593.
        18. Rui Zhang, Nan Yang, Chao Ji, Ji Zheng, Zhen Liang, Chun-Ying Hou, Yan-Yong Liu*, Ping-Ping Zuo*.  Aceglutamide attenuated motor dysfunctions induced by cerebral ischemia injury through suppressing TRAF1-mediated apoptosis signaling pathway. Restorative Neurology and Neuroscience 2015; 33:741–759.
        19. Nan Yang, He Liu, Yao Jiang, Ji Zheng, Dong-mei Li, Chao Ji, Yan-yong Liu*, Pingping Zuo. Improved cognitive function in minimal hepatic encephalopathy rat model：neuroplasticity enhancement. Neural Regeneration Research. 2015, 10(9):1457-1462.
        20. Jie Xu, Rui Zhang, Pingping Zuo, Nan Yang, Chao Ji, Weiran Liu, Yun Wang, Hui Wang, Anshi Wu, Yun Yue, Yanyong Liu*. Aggravation Effect of Isoflurane on Ab25–35-Induced Apoptosis and Tau Hyperphosphorylation in PC12 Cells. Cell Mol Neurobiol  2012; 32:1343–1351. （11）
        21. Tao Wang#, Yanyong Liu#, Nan Yang, Chao Ji, Piu Chan, Pingping Zuo. Anti-parkinsonian effects of octacosanol in MPTP-treated mice. Neural Regen Res. 2012;7(14):1080-1087. (Co-author).
        22. Yanyong Liu#, Haji AkberAisa, Chao Ji, Nan Yang, Haibo Zhu, PingpingZuo. Effects of GossypiumHerbaceam Extract Administration on the Learning and Memory Function in the Naturally Aged Rats: Neuronal Niche Improvement. J Alzheimer’s Dis 2012; 31:101–111.
        23. Yanyong Liu, Nan Yang, Wenyu Hao, Qing Zhao, Tianyi Ying, Shangyi Liu, Qing Li, Yan Liang, Tao Wang, Yilong Dong, Chao Ji, and Pingping Zuo. Dynamic proteomic analysis of protein expression profiles in whole brain of Balb/c mice subjected to unpredictable chronic mild stress: implications for depressive disorders and future therapies. NeurochemInt 2011; 58: 904-913.
        24. Yanyong Liu, Nan Yang, PingpingZuo. cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of Balb/c mice. Cell Mol Neurobiol 2010;30(7):1035-1047.
        25. Yan-yong Liu, Ling Hu, Chao Ji, Dongwen Chen, Xi Shen, Nan Yang, Yun Yue, Jing-mei Jiang, Xia Hong, Qinsheng Ge, Pingping Zuo. Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women. Acta Pharmacologica Sinica 2009; 30: 1065–1070.
        26. Qing Zhang*, Yanyong Liu*, Nan Yang, Xuancai Wan, Pingping Zuo. Nasal administration of cholera toxin B subunit-nerve growth factor improves the space learning and memory abilities in β-amyloid protein25-35-induced amnesic mice. Neuroscience 2008; 155: 234–240.（Co-author）.