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人體解剖與組織胚胎學(xué)系

馬超

負責人：馬超，1999年獲協(xié)和醫科大學(xué)八年制醫學(xué)博士學(xué)位，同年進(jìn)入協(xié)和醫院外科任住院醫師，2000年赴美國耶魯大學(xué)醫學(xué)院麻醉系進(jìn)行博士后研究，2003年起任Associate Research Scientist，2008年起任耶魯大學(xué)醫學(xué)院助理教授。2011年12月回醫科院基礎所工作，任人體解剖與組織胚胎學(xué)系主任、教授、博士生導師。獲得“協(xié)和學(xué)者”榮譽(yù)稱(chēng)號、“中國青年解剖科學(xué)家”、院校“優(yōu)秀教師”、北京腦科學(xué)與類(lèi)腦中心“北腦學(xué)者”、北京市及全國高等教育教學(xué)成果獎等。

主要研究方向：

1. 慢性痛與癢的神經(jīng)機制 Neural Mechanisms of Chronic Pain & Itch

        慢性痛是我國乃至全世界范圍內嚴重影響人們健康生活質(zhì)量的主要問(wèn)題之一。在醫科院基礎所原謝益寬教授實(shí)驗室的基礎上，我們已經(jīng)建立起了一個(gè)神經(jīng)生物學(xué)研究實(shí)驗室和科研梯隊，以神經(jīng)電生理、藥理學(xué)、影像學(xué)、免疫組化和動(dòng)物行為學(xué)為主要手段，以背根神經(jīng)節在體和離體記錄平臺為技術(shù)特色，重點(diǎn)研究慢性痛的免疫相關(guān)機制以及外周感覺(jué)神經(jīng)元的異位放電機理。

        在此基礎上，我還與耶魯大學(xué)醫學(xué)院、協(xié)和醫院等科研和臨床機構開(kāi)展積極合作，將研究范圍推廣到慢性痛與瘙癢患者的病理改變和治療。癢覺(jué)的研究在世界范圍內仍處于起步階段，而其臨床價(jià)值越來(lái)越受到人們的重視。運用類(lèi)似的方法和思路，癢覺(jué)及瘙癢癥的基礎與臨床研究可以與慢性痛的研究同步開(kāi)展。

2. 國家發(fā)育和功能人腦組織資源庫建設與研究項目： National Human Brain bank for Development and Function

        國家發(fā)育和功能人腦組織庫是在北京協(xié)和醫學(xué)院遺體捐獻接收站基礎上建立的以收集保藏人腦組織、服務(wù)國內神經(jīng)科學(xué)相關(guān)研究為目的的公益機構。2019年6月正式納入科技部國家科技資源共享服務(wù)平臺：國家發(fā)育和功能人腦組織資源庫。 截至2020年10月，已接受并保存了319例全腦組織樣本。以人腦組織為基礎，開(kāi)展人腦庫標準化建設、人腦衰老與癡呆相關(guān)的神經(jīng)病理及其相關(guān)機制和多種組學(xué)研究。與北京協(xié)和醫院合作建立了“基于人體組織器官庫的老年人群前瞻性隊列”，完善捐獻者生前神經(jīng)系統檢查（包括MRI等影像學(xué)檢查）及認知評估，結合去世后神經(jīng)病理評估，建立信息完善的組織樣本資源平臺。已為本院校及國內其他單位的多個(gè)研究課題組提供了寶貴的人腦組織樣本，有力的支持了中國的腦科學(xué)與腦疾病研究。

        目前該研究項目已經(jīng)獲得中國醫學(xué)科學(xué)院人體組織器官資源庫建設項目支持。

課題組成員：

現有教授2人（馬超，謝益寬），助理研究員3人，主管技師1人，在讀博士研究生1人，碩士研究生4人，八年制醫學(xué)生科研訓練3人，“大學(xué)生創(chuàng )新基金”5人

熱忱歡迎有志于神經(jīng)生物學(xué)研究的老師和同學(xué)加入！

聯(lián)系方式：Email: mcpumc@163.com ，電話(huà): 010-69156469（Lab）

課題組網(wǎng)頁(yè)：http://anatomy.m.giaogiaogiao.com/viewname.asp?/940.html

 

課題組及人體解剖與組織胚胎學(xué)系師生合影



近5年代表性論著(zhù) （*: 通訊作者）

 [科研論文]

  1. 1.Liu P, Yang Q, Yu N, Cao Y, Wang X, Wang Z, Qiu WY, Ma C*. Phenylalanine Metabolism Is Dysregulated in Human Hippocampus with Alzheimer's Disease Related Pathological Changes. J Alzheimers Dis83(2):609-622, 2021.
  2. 2.Guo Z, Shao C, Zhang Y, Qiu W, Li W, Zhu W, Yang Q, Huang Y, Pan L, Dong Y,Sun H, Xiao X, Sun W*, Ma C*, Zhang L*. A Global Multiregional Proteomic Map of the Human Cerebral Cortex. Genomics, Proteomics & Bioinformatics[Accepted June 24, 2021]
  3. 3.Cui H, Su W, Cao Y, Ma C*,Qiu W*. The altered anatomical distribution of ACE2 in the brain with Alzheimer's Disease pathology. Front Cell Dev Biol2021.
  4. 4.Jia Y, Wang X, Chen Y, Qiu W, Ge W*, MaC*. Proteomic and Transcriptomic Analyses Reveal Pathological Changes in the Entorhinal Cortex Region that Correlate Well with Dysregulation of Ion Transport in Patients with Alzheimer’s Disease. Mol Neurobiol58:4007–4027, 2021.
  5. 5.Cui H, Su W, Cao Y, Ma L, Xu G, Mou W, Zhang Hanlin, Yu Jiawen, Ma C*, ZhangX*,Huang Y. Lack of spinal Neuropeptide Y is involved in mechanical itch in aged mice. Font Aging Neurosci2021.
  6. 6.SuW, Cui H, Wu D, Yu J, Ma L, Zhang X, Huang Y*, Ma C*. Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis. J Neuroinflammation 18:65, 2021
  7. 7.Wang T, Tao J, Fang Y, Ma C*.The Role of Pruriceptors in Enhancing Sensitivity to Pruritogens in a Murine Chronic Compression Model of Dorsal Root Ganglion. Molecular Brain14:15, 2021
  8. 8.Cong C, Zhang W, Qian X, Qiu W*, Ma C*. Significant Overlap of α-Synuclein, Amyloid-β and Phospho-Tau Pathologies in Neuropathological Diagnosis of Lewy-related Pathology: Evidence from China Human Brain Bank. J Alzheimers Dis80:447-458, 2021
  9. 9.Wang T, Zhang Y, Chen W, Tao J, Xue Q, Ge W, Dou W*,Ma C*.Proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy: effects of topical treatment.Biomedicine & Pharmacotherapy133:110844, 2021
  10. 10.Fang Y, Han S, Li X, Xie Y, Zhu B, Gao X*, Ma C*. Cutaneous Hypersensitivity as an Indicator of Visceral Inflammation via C-Nociceptor’s Axon Bifurcation. Neurosci Bull37:45-54, 2021
  11. 11.Liu F, Shen X, Su S, Cui H, Fang Y Wang T, Zhang L,Huang Y, Ma C*.FcγRI-coupled signaling in peripheral nociceptors mediates joint pain in a rat model of rheumatoid arthritis.ArthritisRheumatol72(10):1668-78,2020
  12. 12.He Y, .L, Fang Y, Dan Z, Shen Y, Tan G, Huang Y*, Ma C*. Electrospun PLGA Nanomembrane: A Novel Formulation of Extended- Release Bupivacaine Delivery Reducing Postoperative Pain. Materials & Design 193:108768, 2020
  13. 13.Liu Y, Liu H, Li C, Ma C*, Ge W*. Proteome Profiling of Lung Tissues in Chronic Obstructive Pulmonary Disease (COPD): Platelet and Macrophage Dysfunction Contribute to the Pathogenesis of COPD. Int J Chron Obstruct Pulmon Dis 15:973-980，2020.
  14. 14.Zhang W, ZhangQ, Yang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*,Ma C*.Contribution of Alzheimer’s Disease Neuropathologic Change to the Cognitive Dysfunction in Human Brains with Lewy Body-Related Pathology. Neurobio Aging91:56-65, 2020.
  15. 15.Zhu J, Chen ZY, Fang Y, Duan W, Xie Y, Ma C*. Injury of the Muscular Nerve but not Cutaneous Nerve Drives Acute Neuropathic Pain. Neurosci Bull36:453–462,2020. [Cover Article]
  16. 16.Fang Y, Zhu J, Duan W, Xie Y, Ma C*. Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain. Neurosci Bull36:1-10, 2019.
  17. 17.Chen Z, Wang T, Fang Y, Luo D, Anderson M, Huang Q, He S, Song X, Cui H, Dong X, Xie Y, Guan Y*, Ma C*. Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy. Sci Rep9:7651, 2019.
  18. 18.Jiang H, Cui H, Wang T, Shimada SG, Sun R, Tan Z, Ma C*, LaMotte RH*. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain BehavImmun80:464–473, 2019.
  19. 19.Wang X, Xia W, Li K, Zhang Y, Ge W*, Ma C*.Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse.J Neurol Sci 399:125-139, 2019.
  20. 20.Xiong F, Ge W*, Ma C*. Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association15(3):429–440,2019. doi: 10.1016/j.jalz.2018.10.006.
  21. 21.Yang Q, Chen K, Zhang H, Zhang W, Gong C, Zhang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W*,Ma C*. Correlations between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease among Han Chinese. Neurosci Bull35(2):193-204, 2019
  22. 22.Zhang F, Wei J, Li X, Ma C*, Gao Y*. Early candidate urine biomarkers for detecting Alzheimer's disease before beta amyloid plaque deposition in an APP (swe)/PSEN1dE9 transgenic mouse model. J Alzheimers Dis66:613–637, 2018.
  23. 23.Zhang H, Chen K, Wang N, Zhang D, Yang Q, Zhang Q, Liu P, Wang M, Gong C, Hong X, Qiu W, Qian X, Chen Y*, Ma C*. Analysis of Brain Donors' Demographic and Medical Characteristics to Facilitate the Construction of a Human Brain Bank in China. J Alzheimers Dis66:1245–1254, 2018.
  24. 24.Xu Z, Wang T, Guo X, Li Y, Hu Y, Ma C*, Wang J*. The relationship of serum antigen-specific and total immunoglobulin E with adult cardiovascular diseases. Int J Med Sci 15 (11):1098-1104, 2018.doi: 10.7150/ijms.25857.
  25. 25.Wang Z, Liu F, Wei M, Qiu Y, Ma C*, Shen L*, Huang Y*.Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway. J Neuroinflammation 15(1):179, 2018.
  26. 26.Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C*, LaMotte RH*. Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.Neurosci Lett668:154–158,2018.
  27. 27.Li J, Zhang W, Wang X, Yuan T, Liu P, Wang T, Shen L, Huang Y, Li N, You H, Xiao T, Feng F*, Ma C*. Functional magnetic resonance imaging reveals differences in brain activation in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy. PLoS One13(1): e0190699, 2018.
  28. 28.Qiu W, Yang Q, Zhang W, Wang N, Zhang D, Huang Y, Ma C*. The Correlations Between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and Alzheimer’s Disease. Curr Alz Res15:1-12, 2018.

[綜述和論著(zhù)]

  1. 29.Li HY*, Wang F, Chen M, Zheng ZJ, Yin YJ, Hu J, Li H, Sammer A, Feigl G, Maurer N, Ma C*, Ji FS*. An acupoint-originated human interstitial fluid circulatory network. Chin Med J, 2021.
  2. 30.Tang K, Wang M, Zhang H, Zhang Q, Yang Q, Chen K, Wang N, Zhang D, Qiu W*,Ma C*. The top 100 most-cited articles citing human brain banking from 1970 to 2020: a bibliometric analysis. Cell and Tissue Banking, 21:685–697, 2020.
  3. 31.SuS, Cui H, WangT, ShenX. Ma C*. Pain: A Potential New Label of COVID-19.Brain Behav Immun87:159-160, 2020.
  4. 32.He Y, Qin L, Huang Y, Ma C*. Advances of Nano-Structured Extended-Release Local Anesthetics. Nanoscale Res Lett 15:13, 2020.
  5. 33.Vornholt E, Luo D, Qiu W, McMichael GO, Liu Y, Gillespie N, Ma C*, Vladimirov VI*.Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations. Neurosci Biobehav Rev102:195-207, 2019.
  6. 34.Ma C*, Bao AM, Yan XX, Swaab DF. Progress in Human Brain Banking in China.Neurosci Bull.35(2):179-182, 2019.
  7. 35.Qiu W, Zhang H, Bao A, Zhu K, Huang Y, Yan X, Zhang J, Zhong C, Shen Y, Zhou J, Zheng X, Zhang L, Shu Y, Tang B, Zhang Z, Wang G, Zhou R, Sun B, Gong C, Duan S, Ma C*. Standardized Operational Protocol for Human Brain Banking in China.Neurosci Bull.35(2):270-276, 2019.