蔣澄宇

導師簡(jiǎn)介：

蔣澄宇，中國醫學(xué)科學(xué)院基礎醫學(xué)研究所研究員，北京協(xié)和醫學(xué)院教授。畢業(yè)于中國科學(xué)技術(shù)大學(xué)生物系，獲理學(xué)學(xué)士學(xué)位；美國布朗大學(xué)醫學(xué)院病理與實(shí)驗室藥學(xué)系，獲博士學(xué)位。隨后于哈佛醫學(xué)院麻省總醫院從事博士后工作。蔣澄宇回國后致力于植物藥新組分小RNA的藥理學(xué)及呼吸系統肺損傷相關(guān)疾病研究。發(fā)現了草藥新的有效成分小RNA以脂質(zhì)湯劑體形式進(jìn)入機體的遞送方式，闡述了植物來(lái)源小RNA的藥效機理。解析了不同病原體引起的病死率高達20%-50%的嚴重呼吸窘迫綜合癥（ARDS）的分子機制，提出了臨床診斷或干預方法。研究論文發(fā)表在Nature，Nature Medicine，Molecular Psychiatry，Cell Research和Nature Communications等雜志，連續5年入選愛(ài)思唯爾中國高被引學(xué)者榜單。蔣澄宇現任中國生物化學(xué)與分子生物學(xué)學(xué)會(huì )副理事長(cháng)，北京市生物化學(xué)與分子生物學(xué)學(xué)會(huì )理事長(cháng)。先后獲得國家杰出青年基金，中國青年女科學(xué)家等榮譽(yù)稱(chēng)號，是973研究計劃呼吸系統疾病領(lǐng)域項目的首席科學(xué)家。

實(shí)驗室簡(jiǎn)介：

實(shí)驗室自從2003年建立以來(lái)，長(cháng)期致力于呼吸系統肺損傷相關(guān)疾病的致病機理的研究和藥物研發(fā)。闡述了SARS冠狀病毒，禽流感H5N1，甲流，和艾博拉等病毒和微納米細顆粒物引發(fā)致病的分子機理。研究成果發(fā)表在《自然》、《自然·醫學(xué)》、《自然·通訊》、和《科學(xué)·信號》等雜志上。曾獲得中, 美, 歐盟等國專(zhuān)利，并曾獨家轉讓給世界排名前五名的制藥公司和歐盟的生物技術(shù)公司。目前課題組有教授1名，副研究員1名，助理研究員1名，高級技師1名，博士后2名，技術(shù)員2名，研究生10余名。

代表性論文：

1.             Du, J., Liang, Z., Xu, J., Zhao, Y., Li, X., Zhang, Y., ... & Jiang, C. (2017). Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7. Science China Life Sciences, 1-12.

2.         Zhang, Y.L., Tang, J., Yang, N., Liu, Q., Zhang, Q.C., Zhang, Y.X., Li, N., Zhao, Y., Li, S.W., Liu, S., Zhou, H.D., Li, X., Tian, M.Y., Deng, J.J., Xie, P., Sun, Y., Lu, H.J., Zhang, M.Q., Jin, N.Y., Jiang, C., FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN, Journal of Immunology, 2016

3.         Ju X., Yan Y., Liu Q., Li N., Sheng M., Zhang L., Li X., Liang Z., Huang F., Liu K., Zhao Y., Zhang Y., Zou Z., Du J., Zhong Y., Zhou H., Yang P., Lu H., Tian M., Li D., Zhang J., Jin N., Jiang C. Neuraminidase of influenza A virus binds lysosome-associated membrane proteins directly and induces lysosome rupture, Journal of Virology, 2015

4.             Zou, Z, Yan, Y, Shu, Y, Gao, R, Sun, Y, Li, X, Ju, X, Liang, Z, Liu, Q, Zhao, Y, Guo, F, Bai, T, Han, Z, Zhu, J, Zhou, H, Huang, F, Li, C, Lu, H, Li, N, Li, D, Jin, N, Penninger*, JM, Jiang*, C (2014) Angiotensin-Converting Enzyme 2 protects from lethal Avian Influenca A H5N1 Infections Nat Commun 10.1038/ncomms4594.

5.             Huang, F, Guo, J, Zou, Z, Liu, J, Cao, B, Zhang, S, Li, H, Wang, W, Sheng, M, Liu, S, Pan, J, Bao, C, Zeng, M, Xiao, H, Qian, G, Hu, X, Chen, Y, Chen, Y, Zhao, Y, Liu, Q, Zhou, H, Zhu, J, Gao, H, Yang, S, Liu X, Zheng, S, Yang, J, Diao, H, Cao, H, Wu, Y, Zhao, M, Tan, S, Guo, D, Zhao, X, Ye,Y, Wu, W, Xu, Y, Penninger, JM, Li, D, Gao*, G, Jiang*, C, Li*, L (2014) Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun 10.1038/ncomms4595

6.             Xu*, C, Ju, X, Song, D, Huang, F, Tang D, Zou, Z, Zhang, C, Joshi, T, Jia, L, Xu, W, Xu, K, Wang, Q, Xiong, Y, Guo, Z, Chen, X, Huang, F, Xu, J, Zhong, Y, Zhu, Y, Peg, Y, Wang, L, Zhang, X, Jiang, R, Li, D, Jiang, T, Xu, D, Jiang*, C (2014) An association analysis between psychophysical characteristics and genome-wide gene expression changes in human adaption to the extreme climate at the Antarctic Dome Argus Mol Psychiatry 10.1038/mp.2014.72.

7.             Sheng, M, Zhong, Y, Chen, Y, Du, J, Ju, X, Zhao, C, Zhang, G, Zhang, L, Liu, K, Yang, N, Xie, P, Li, D, Zhang*, M.Q, Jiang*, C (2014) Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro Sci China Life Sci. 57(10):959-72

8.             Wang, W, Yang, P, Zhong, Y, Zhao, Z, Xing, L, Zhao, Y, Zou, Z, Zhang, Y, Li, C, Li, T, Wang, C, Wang, Z, Yu, X, Cao, B, Gao, X, Penninger, J, Wang*, X, Jiang*, C (2013) Monoclonal Antibody Against CXCL-10/ IP-10 Ameliorated Influenza A (H1N1) Induced Acute Lung Injury. Cell Res. 23:577-580

9.             Yan, Y, Zou, Z, Sun, Y, Li, X, Xu, K, Wei, Y, Jin*, N, Jiang*, C (2013) Anti-Malaria Drug Chloroquine is Highly Effective in Treating Avian Influenza A H5N1 Virus Infection in an Animal Model Cell Res. 23:300-302

10.         Zhang, Y, Deng, J, Zhang, Y, Guo, F, Li, C, Zou, Z, Xi, W, Tang, J, Sun, Y, Yang, P, Han, Z, Jiang*, C (2013) Functionalized Single-Walled Carbon Nanotubes Cause Reversible Acute Lung Injury and Induce Fibrosis in Mice J. Mol. Med. 91:117-128

11.      Sun, Y, Li, C, Shu, Y, Wang, H, Ju, X, Zou, Z，Wang, H, Rao, S, Guo, F, Liu, H, Nan, W, Zhao, Y, Yan, Y, Tang, J, Zhao, C, Yang, P, Liu, K, Wang, S, Lu, H, Li, X, Tan, L, Gao, R, Song, J, Gao, X, Tan, X, Qin, Y, Xu, K, Li D, Jin*, N, Jiang*, C (2012) Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection. Science Signaling (Cover Story) 5 (212) ra16

12.      Yang, N, Ma, P, Lang, J, Zhang, Y, Deng, J, Ju, X, Zhang, G, Jiang*, C (2012) Phosphatidylinositol 4-Kinase III_ Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry. J. Biol. Chem. 287(11) 8457-8467

13.      Li, C, Yang, P, Sun, Y, Li, T, Wang, C, Wang, Z, Zou, Z, Yan, Y, Wang, W, Wang, C, Chen, Z, Xing, L, Tang, C, Ju, X, Guo, F, Deng, J, Zhao, Y, Yang, P, Tang, J, Wang, H, Zhao, Z, Yin, Z, Cao, B, Wang*, X, Jiang*, C (2012) IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus. Cell Res. 22:528-538