国产精品玖玖玖在线观看_免疫學(xué)系-中國醫學(xué)科學(xué)院基礎醫學(xué)研究所

葛微

葛微教授

葛微博士，教授，博士生導師，中國醫學(xué)科學(xué)院基礎醫學(xué)研究所免疫系課題組長(cháng)（PI）

葛微教授本科畢業(yè)于北京師范大學(xué)化學(xué)系，2005年在牛津大學(xué)取得博士學(xué)位，師從Professor Sir Jack. E. Baldwin，2005-2012年在牛津大學(xué)Professor Christopher J Schofield課題組做博士后研究。2013年回國后被聘為中國醫學(xué)科學(xué)院基礎醫學(xué)研究所免疫系教授，博士生導師，獲得協(xié)和學(xué)者稱(chēng)號。在Alzheimer’s & Dementia，Nature Chemical Biology, Angewandte Chemie，Leukemia和Bone Research等期刊上以通訊作者的身份發(fā)表SCI論文70余篇，取得國際PTC發(fā)明專(zhuān)利3項。主持國家自然科學(xué)基金面上項目2項，諾和諾德英才基金1項。參與國家自然科學(xué)基金2項。

培養博士后2名，研究生15名，其中獲得國家獎學(xué)金7人次，北京市優(yōu)秀畢業(yè)生3人次。學(xué)生獲得校內基金7項。

研究興趣和方向

1. 基于中國人腦的神經(jīng)退行性疾病分子機制研究。

2. 結直腸癌的免疫應答分子機制的研究。

Publications:

2022年（6篇） 2021年（7篇） 2020年（5篇） 2019年（12篇） 2018年（8篇） 2017（10篇） 2016（9篇） 2015年（6篇） 2014年（8篇） 2013年（3篇） 2012-2008年（13篇）【超鏈接】

聯(lián)系方式：

辦公電話(huà)：010-69156470

郵箱：gewei@ibms.cams.cn；gewei666@hotmail.com

辦公室：可勝大樓347室

（鏈接）

2022年

(1) Liu H, Xie Y, Wang X, Abboud MI, Ma C, Ge W, Schofield CJ, Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease. Alzheimer’s Dement. 2022 July, DOI: 10.1002/alz.12733

(2) Hou W, Pan M, Ge W, Xiao Y, Serum extracellular vesicle stratifin is a biomarker of perineural invasion in patients with colorectal cancer and predicts worse prognosis, Front. Oncol. 2022 July doi: 10.3389/fonc.2022.912584

(3) Dan Luo, Haotian Liu, Hanyou Liu , Wei Wu , Hanyang Zhu , Wei Ge , Chao Ma. Long RNA Profiles of Human Brain Extracellular Vesicles Provide New Insights into the Pathogenesis of Alzheimer’s Disease. Aging and disease. 2022 https://doi.org/10.14336/AD.2022.0607

(4) Gao Y, Liu J, Wang J, Liu Y, Zeng LH, Ge W, Ma C. Proteomic analysis of human hippocampal subfields provides new insights into the pathogenesis of Alzheimer's disease and the role of glial cells. Brain Pathol. 2022 Jan 11:e13047. doi: 10.1111/bpa.13047.

(5) Zhan S, Wang T, Li J, Zhu H, Ge W, Li J. Asporin Interacts With HER2 to Promote Thyroid Cancer Metastasis via the MAPK/EMT Signaling Pathway. Original Research. Frontiers in Oncology. 2022;12doi:10.3389/fonc.2022.762180

(6) 占少華, 矯禎浩, 葛微, 王天笑. 散發(fā)性甲狀腺髓樣癌組織中Asporin蛋白的臨床價(jià)值[J]. 基礎醫學(xué)與臨床, 2022, 42(8): 1269-1271.

2021年

(1) Gao, Y., Chen, Y., Wang, L., Li, C., & Ge, W. (2021). Serum-derived extracellular vesicles inhibit osteoclastogenesis in active-phase patients with SAPHO syndrome. Ther Adv Musculoskelet Dis, 13, 1759720x211006966. doi:10.1177/1759720x211006966

(2) Jia, Y., Wang, X., Chen, Y., Qiu, W., Ge, W., & Ma, C. (2021). Proteomic and Transcriptomic Analyses Reveal Pathological Changes in the Entorhinal Cortex Region that Correlate Well with Dysregulation of Ion Transport in Patients with Alzheimer's Disease. Mol Neurobiol. doi:10.1007/s12035-021-02356-3

(3) Wang, T., Zhang, Y., Chen, W., Tao, J., Xue, Q., Ge, W., . . . Ma, C. (2021). Proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy: Effects of topical treatment. Biomedicine & Pharmacotherapy, 133, 110844. doi:https://doi.org/10.1016/j.biopha.2020.110844

(4) Wang, X., Han, C., Jia, Y., Wang, J., Ge, W., & Duan, L. (2021). Proteomic Profiling of Exosomes From Hemorrhagic Moyamoya Disease and Dysfunction of Mitochondria in Endothelial Cells. Stroke, Strokeaha120032297. doi:10.1161/strokeaha.120.032297

(5) Zhang P, Zhang Y, Pan M, Liu Z, Li J, Peng L, Zhou J, Hu C, Liu S, Zeng X, Ge W, Zhang W. Proteomic analyses of plasma-derived exosomes in immunoglobulin (Ig) G4-related disease and their potential roles in B cell differentiation and tissue damage. J Autoimmun. 2021 Aug;122:102650. doi: 10.1016/j.jaut.2021.102650. Epub 2021 Jun 6. PMID: 34107438.

(6) Zhang, Y., Li, C. Y., Ge, W., & Xiao, Y. (2021). Exploration of the Key Proteins in the Normal-Adenoma-Carcinoma Sequence of Colorectal Cancer Evolution Using In-Depth Quantitative Proteomics. J Oncol, 2021, 5570058. doi:10.1155/2021/5570058

(7) Zhang Y, Pan M, Li CY, Li JY, Ge W, Xu L, Xiao Y. Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis. Bioengineered. 2021 Dec;12(1):6831-6843. doi: 10.1080/21655979.2021.1971036.

2020年

(1) Zhang Y, Liu Y, Jia Y, Zhao Y, Ma C, Bao X, Meng X, Dou W, Wang X, Ge W. Proteomic profiling of sclerotic hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy. Epilepsy Res. 2020 Oct;166:106412. doi: 10.1016/j.eplepsyres.2020.106412. Epub 2020 Jul 1. PMID: 32668389.

(2) Wang X, Chen K, Pan M, Ge W, He Z. Comparison of proteome alterations during aging in the temporal lobe of humans and rhesus macaques. Exp Brain Res. 2020 Sep;238(9):1963-1976. doi: 10.1007/s00221-020-05855-2. Epub 2020 Jun 22. PMID: 32572507.

(3) Meng S, Xia W, Pan M, Jia Y, He Z, Ge W. Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys. BMC Neurosci. 2020 Jan 15;21(1):2. doi: 10.1186/s12868-020-0550-4. PMID: 31941443; PMCID: PMC6964096.

(4) Luo D, Ge W. MeCP2 Promotes Colorectal Cancer Metastasis by Modulating ZEB1 Transcription. Cancers (Basel). 2020 Mar 23;12(3):758. doi: 10.3390/cancers12030758. PMID: 32210086; PMCID: PMC7140043.

(5) Liu Y, Liu H, Li C, Ma C, Ge W. Proteome Profiling of Lung Tissues in Chronic Obstructive Pulmonary Disease (COPD): Platelet and Macrophage Dysfunction Contribute to the Pathogenesis of COPD. Int J Chron Obstruct Pulmon Dis. 2020 May 5;15:973-980. doi: 10.2147/COPD.S246845. PMID: 32440109; PMCID: PMC7211305.

2019年

(1) Zhong ME, Chen Y, Zhang G, Xu L, Ge W, Wu B. LncRNA H19 regulates PI3K-Akt signal pathway by functioning as a ceRNA and predicts poor prognosis in colorectal cancer: integrative analysis of dysregulated ncRNA-associated ceRNA network. Cancer Cell Int. 2019 May 30;19:148. doi: 10.1186/s12935-019-0866-2. PMID: 31164794; PMCID: PMC6543669.

(2) Zhong ME, Chen Y, Xiao Y, Xu L, Zhang G, Lu J, Qiu H, Ge W, Wu B. Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. EBioMedicine. 2019 Dec;50:211-223. doi: 10.1016/j.ebiom.2019.11.003. Epub 2019 Nov 18. PMID: 31753726; PMCID: PMC6921233.

(3) Zhan S, Wang T, Wang M, Li J, Ge W. In-Depth Proteomics Analysis to Identify Biomarkers of Papillary Thyroid Cancer Patients Older Than 45 Years with Different Degrees of Lymph Node Metastases. Proteomics Clin Appl. 2019 Sep;13(5):e1900030. doi: 10.1002/prca.201900030. Epub 2019 Jun 7. PMID: 31148369.

(4) Zhan S, Wang T, Wang M, Li J, Ge W. In-Depth Proteomics Analysis to Identify Biomarkers of Papillary Thyroid Cancer Patients Older Than 45 Years with Different Degrees of Lymph Node Metastases. Proteomics Clin Appl. 2019 Sep;13(5):e1900030. doi: 10.1002/prca.201900030. Epub 2019 Jun 7. PMID: 31148369.

(5) Zhan S, Li J, Ge W. Multifaceted Roles of Asporin in Cancer: Current Understanding. Front Oncol. 2019 Sep 24;9:948. doi: 10.3389/fonc.2019.00948. PMID: 31608236; PMCID: PMC6771297.

(6) Xiong F, Ge W, Ma C. Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease. Alzheimers Dement. 2019 Mar;15(3):429-440. doi: 10.1016/j.jalz.2018.10.006. Epub 2019 Jan 2. PMID: 30502339.

(7) Xie Y, Zhang L, Xiong Q, Gao Y, Ge W, Tang P. Bench-to-bedside strategies for osteoporotic fracture: From osteoimmunology to mechanosensation. Bone Res. 2019 Aug 15;7:25. doi: 10.1038/s41413-019-0066-7. PMID: 31646015; PMCID: PMC6804735.

(8) Xie Y, Zhan S, Ge W, Tang P. The potential risks of C-C chemokine receptor 5-edited babies in bone development. Bone Res. 2019 Jan 29;7:4. doi: 10.1038/s41413-019-0044-0. PMID: 30701110; PMCID: PMC6351561.

(9) Xie Y, Pan M, Gao Y, Zhang L, Ge W, Tang P. Dose-dependent roles of aspirin and other non-steroidal anti-inflammatory drugs in abnormal bone remodeling and skeletal regeneration. Cell Biosci. 2019 Dec 23;9:103. doi: 10.1186/s13578-019-0369-9. PMID: 31890152; PMCID: PMC6929289.

(10) Wang X, Xia W, Li K, Zhang Y, Ge W, Ma C. Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse. J Neurol Sci. 2019 Apr 15;399:125-139. doi: 10.1016/j.jns.2019.02.022. Epub 2019 Feb 14. PMID: 30798110.

(11) Wang X, Liu Y, Jia Y, Liu H, Bao X, He Z, Ge W. Proteome Profiling of Cerebral Vessels in Rhesus Macaques: Dysregulation of Antioxidant Activity and Extracellular Matrix Proteins Contributes to Cerebrovascular Aging in Rhesus Macaques. Front Aging Neurosci. 2019 Oct 23;11:293. doi: 10.3389/fnagi.2019.00293. PMID: 31708766; PMCID: PMC6819311.

(12) Meng S, Zhan S, Dou W, Ge W. The interactome and proteomic responses of ALKBH7 in cell lines by in-depth proteomics analysis. Proteome Sci. 2019 Dec 29;17:8. doi: 10.1186/s12953-019-0156-x. PMID: 31889914; PMCID: PMC6935500.

2018年

(1) Zhan S, Wang T, Ge W, Li J. Multiple roles of Ring 1 and YY1 binding protein in physiology and disease. J Cell Mol Med. 2018 Apr;22(4):2046-2054. doi: 10.1111/jcmm.13503. Epub 2018 Jan 31. PMID: 29383875; PMCID: PMC5867070.

(2) Zhan S, Li J, Wang T, Ge W. Quantitative Proteomics Analysis of Sporadic Medullary Thyroid Cancer Reveals FN1 as a Potential Novel Candidate Prognostic Biomarker. Oncologist. 2018 Dec;23(12):1415-1425. doi: 10.1634/theoncologist.2017-0399. Epub 2018 May 8. PMID: 29739896; PMCID: PMC6292558.

(3) Xu B, Zhang Y, Zhan S, Wang X, Zhang H, Meng X, Ge W. Proteomic Profiling of Brain and Testis Reveals the Diverse Changes in Ribosomal Proteins in fmr1 Knockout Mice. Neuroscience. 2018 Feb 10;371:469-483. doi: 10.1016/j.neuroscience.2017.12.023. Epub 2017 Dec 30. PMID: 29292077.

(4) Xie Y, Gao Y, Zhang L, Chen Y, Ge W, Tang P. Involvement of serum-derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone-related proteins. Aging Cell. 2018 Jun;17(3):e12758. doi: 10.1111/acel.12758. Epub 2018 Mar 30. PMID: 29603567; PMCID: PMC5946082.

(5) Luo D, Zhan S, Xia W, Huang L, Ge W, Wang T. Proteomics study of serum exosomes from papillary thyroid cancer patients. Endocr Relat Cancer. 2018 Oct;25(10):879-891. doi: 10.1530/ERC-17-0547. Epub 2018 Jun 12. PMID: 29895528.

(6) Guo Y, Xu B, Sun Z, Wu Y, Shi W, Wang J, Meng X, Ge W, Wang G. Quantitative protein profiling and pathway analysis of spinal arteriovenous malformations. Microvasc Res. 2018 Nov;120:47-54. doi: 10.1016/j.mvr.2018.06.002. Epub 2018 Jun 12. PMID: 29902475.

(7) Gao Y, Ge W. The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis. Cell Death Dis. 2018 Jan 18;9(2):33. doi: 10.1038/s41419-017-0040-5. PMID: 29348610; PMCID: PMC5833786.

(8) 孟姝, 王霞, 葛微,等. 化學(xué)生物學(xué)小班教學(xué)方法研究與實(shí)踐[J]. 基礎醫學(xué)與臨床, 2018, 38(2):4.

2017年

(1) Xu B, Zhao Y, Wang X, Gong P, Wei G. MZH29 is a novel potent inhibitor that overcomes drug resistance-FLT3 mutations in acute myeloid leukemia. Leukemia 2017, 31: 913-921.

(2) Yanpan Gao, Yanyu Chen, Shaohua Zhan, Wenhao Zhang, Feng Xiong and Wei Ge. Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses. Oncotarget, 2017, Vol. 8, (No. 5), pp: 7420-7440.

(3) Shaohua Zhan, Tianxiao Wang, Wei Ge. Multiple functions of the E3 ubiquitin ligase CHIP in immunity. Int Rev Immunol. 2017 Jun 2:1-13.

(4) Rachel Chun Yee Tam, Michelle Wing Man Li, Yan Pan Gao, Yuen Ting Pang, Sheng Yan, Wei Ge, Chak Sing Lau. Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research. 2017 Mar 15;352(2):304-312.

(5) Qingzhong He, Wei Ge. The tandem Agenet domain of fragile X mental retardation protein interacts with FUS. Scientific reports, 2017, 7, 962.

(6) Benhong Xu*, Yanpan Gao*, Shaohua Zhan and Wei Ge. Quantitative proteomic profiling for clarification of the crucial roles of lysosomes in microbial infections. Molecular Immunology. 2017, 87, 122-131.

(7) Fuxing Zuo, Feng Xiong, Xia Wang, Xueyuan Li, Renzhi Wang, Wei Ge, Xinjie Bao. Intrastriatal Transplantation of Human Neural Stem Cells Restores the Impaired Subventricular Zone in Parkinsonian Mice. Stem Cells 2017 35 (6): 1519-1531.

(8) Yanyu Chen, Yong Xie, Lai Xu, Shaohua Zhan, Yi Xiao, Yanpan Gao, Bin Wu, Wei Ge. Protein content and functional characteristics of serum-purified exosomes from patients with colorectal cancer revealed by quantitative proteomics. International Journal of Cancer. 2017 Feb 15;140(4):900-913.

(9) Xia Wang, Qiang Hao, Yuanli Zhao, Yi Guo, Wei Ge. Dysregulation of cell-cell interactions in brain arteriovenous malformations: A quantitative proteomic study. Proteomics Clin Appl 2017 11(5-6).

(10) Yong Xie, Yanyu Chen, Licheng Zhang, Wei Ge, Peifu Tang. The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodeling. J Cell Mol Med 2017, 21, 1033-1041.

2016年

(1) Xu L, Gao Y, Chen Y, Xiao Y, He Q, Qiu H, Ge W. Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer. Oncotarget 2016, 7, 43868-43893.

(2) Xiong Q, Zhan S, Zhang N, Ge W, Wang T: Protein progiling of papillary thyroid carcinoma with and without lymph node metastasis: a proteomic study. Int J Clin Exp Pathol 2016, 9(3):3057-3069.

(3) Xu B, Xiong F, Tian R, Zhan S, Gao Y, Qiu W, Wang R, Ge W, Ma C: Temporal lobe in human aging: A quantitative protein profiling study of samples from Chinese Human Brain Bank. Exp Gerontol 2016, 73:31-41.

(4) Xu B, Tian R, Wang X, Zhan S, Wang R, Guo Y, Ge W: Protein profile changes in the frontotemporal lobes in human severe traumatic brain injury. Brain Res 2016, 1642:344-52.

(5) Xu B, Gao Y, Zhan S, Xiong F, Qiu W, Qian X, Wang T, Wang N, Zhang D, Yang Q, Wang R, Bao X, Dou W, Tian R, Meng S, Gai WP, Huang Y, Yan XX, Ge W, Ma C: Quantitative protein profiling of hippocampus during human aging. Neurobiol Aging 2016, 39:46-56.

(6) Xiong Q, Zhang L, Zhan S, Ge W, Tang P: Investigation of proteome changes in osteoclastogenesis in low serum culture system using quantitative proteomics. Proteome Sci 2016, 14:8.

(7) Xiong Q, Zhang L, Ge W, Tang P: The roles of interferons in osteoclasts and osteoclastogenesis. Joint Bone Spine 2016, 83(3):276-81.

(8) Xin L, Xu B, Ma L, Hou Q, Ye M, Meng S, Ding X, Ge W: Proteomics study reveals that the dysregulation of focal adhesion and ribosome contribute to early pregnancy loss. Proteomics Clin Appl 2016, 10(5):554-563.

(9) Xiong Q, Ge W. Gene mutations in Cushing’s disease. Biomedical Reports. 2016, 5(3):277-282.

2015年

(1) Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, Su X, Liu J, Ge W, Levine RL, Li N, Cao X: Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature 2015, 525(7569):389-393

(2) Yang J, Gao Y, Liu W, Ge W, Zhao R: The degradation and mineralization of acephate by ionization irradiation. Environ Prog Sustain 2015, 34(2):324-332.

(3) Xiong Q, Zhang L, Xin L, Gao Y, Peng Y, Tang P, Ge W: Proteomic study of different culture medium serum volume fractions on RANKL-dependent RAW264.7 cells differentiating into osteoclasts. Proteome Sci 2015, 13:16.

(4) Xiong Q, Tang P, Gao Y, Zhang L, Ge W: Proteomic Analysis of Estrogen-Mediated Signal Transduction in Osteoclasts Formation. Biomed Res Int 2015, 2015:596789.

(5) Xie Y, Zhang L, Gao Y, Ge W, Tang P: The Multiple Roles of Microrna-223 in Regulating Bone Metabolism. Molecules 2015, 20(10):19433-19448.

(6) Su X, Wang H, Ge W, Yang M, Hou J, Chen T, Li N, Cao X: An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer. Cancer Res 2015, 75(14):2875-2885.

(7) Jin J, Xiao Y, Hu H, Zou Q, Li Y, Gao Y, Ge W, Cheng X, Sun SC: Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun 2015, 6:5930.

(8) Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA: Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure 2015, 23(4):639-652.

(9) Ge W, Li D, Gao Y, Cao X: The Roles of Lysosomes in Inflammation and Autoimmune Diseases. Int Rev Immunol 2015, 34(5):415-431.

2014年

(1) Tang P, Xiong Q, Ge W, Zhang L. The role of microRNAs in osteoclasts and osteoporosis. RNA biology 2014;11: 1355-63.

(2) Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JR, Vollmar M, et al. Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature 2014;510: 422-6.

(3) Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Munzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Ge W, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Molecular cell 2014;53: 645-54.

(4) He Q, Ge W. FMRP: a new chapter with chromatin. Protein & cell 2014;5: 885-8.

(5) He Q, Zhang H, Wang Y, Ting HH, Yu W, Cao X, Ge W. Purified anti-CD3 x anti-HER2 bispecific antibody potentiates cytokine-induced killer cells of poor spontaneous cytotoxicity against breast cancer cells. Cell & bioscience 2014;4: 70.

(6) Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proceedings of the National Academy of Sciences of the United States of America 2014;111: 4019-24.

(7) Scotti JS, Leung IK, Ge W, Bentley MA, Paps J, Kramer HB, Lee J, Aik W, Choi H, Paulsen SM, Bowman LA, Loik ND, et al. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proceedings of the National Academy of Sciences of the United States of America 2014;111: 13331-6.

(8) Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proceedings of the National Academy of Sciences of the United States of America 2014;111: 4031-6.

2013年

(1) Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angewandte Chemie (International ed in English) 2013;52: 1700-4.

(2) Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site. FEBS letters 2013;587: 2705-9.

(3) Huang L, Liu Y, Wang L, Chen R, Ge W, Lin Z, Zhang Y, Liu S, Shan Y, Lin Q, Jiang M. Down-regulation of miR-301a suppresses pro-inflammatory cytokines in Toll-like receptor-triggered macrophages. Immunology 2013;140: 314-22.

2012-2008年

(1) Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase? Journal of the American Chemical Society 2008;130: 10096-102.

(2) Ge W, Clifton IJ, Howard-Jones AR, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue. Chembiochem : a European journal of chemical biology 2009;10: 2025-31.

(3) Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Lienard BM, Schofield CJ, Clifton IJ. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorganic & medicinal chemistry letters 2010;20: 6125-8.

(4) Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase. Biochemical and biophysical research communications 2010;398: 659-64.

(5) Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase. Organic & biomolecular chemistry 2010;8: 122-7.

(6) Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Human molecular genetics 2010;19: 217-22.

(7) Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. FEBS letters 2010;584: 825-30.

(8) Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of isopenicillin N synthase with delta-((L)-alpha-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron. Archives of biochemistry and biophysics 2011;516: 103-7.

(9) Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. Isopenicillin N synthase binds delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms. Chembiochem : a European journal of chemical biology 2011;12: 1881-5.

(10) Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe PJ, Schofield CJ. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The FEBS journal 2011;278: 1086-97.

(11) Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ. Asparagine and aspartate hydroxylation of the cytoskeletal Ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. The Journal of biological chemistry 2011;286: 7648-60.

(12) Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature chemical biology 2012;8: 960-2.

(13) Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, et al. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angewandte Chemie (International ed in English) 2012;51: 1631-4.

王霞助理研究員

王霞博士畢業(yè)于北京師范大學(xué)化學(xué)系，2010-2015年就讀于放射性藥物化學(xué)領(lǐng)域劉伯里院士課題組，師從賈紅梅教授，獲理學(xué)博士學(xué)位。2015年加入中國醫學(xué)科學(xué)院基礎醫學(xué)研究所作助理研究員，2021年獲得副研究員資質(zhì)。研究方向主要是：基于國家發(fā)育和功能人腦組織庫，開(kāi)展阿爾茨海默病的發(fā)病機制探索，及腦血管疾病發(fā)病機制探索。以第一作者或通訊作者在Stroke, Alzheimer Dementia, J Med Chem等期刊發(fā)表論文，主持國家自然科學(xué)基金項目2項，授權國家發(fā)明專(zhuān)利1項。

研究興趣和方向：

中樞神經(jīng)系統疾病的早期診斷及發(fā)病機制的研究。
小分子藥物對中樞神經(jīng)系統疾病的治療。

Publications:

(1) Wang X#, Han C#, Jia Y, Wang J, Ge W*, Duan L*. Proteomic Profiling of Exosomes From Hemorrhagic Moyamoya Disease and Dysfunction of Mitochondria in Endothelial Cells. Stroke. 2021 Oct;52(10):3351-3361.

(2) Liu H#, Xie Y#, Wang X#, et al. Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease. Alzheimer's & Dementia. 2022.

(3) Wang X#, Liu Y#, Jia Y, Liu H, Bao X, He Z*, Ge W*. Proteome Profiling of Cerebral Vessels in Rhesus Macaques: Dysregulation of Antioxidant Activity and Extracellular Matrix Proteins Contributes to Cerebrovascular Aging in Rhesus Macaques. Front Aging Neurosci. 2019 Oct 23;11:293.

(4) Fuxing Zuo#, Feng Xiong#, Xia Wang#, Xueyuan Li, Renzhi Wang*, Wei Ge*, Xinjie Bao*. Intrastriatal Transplantation of Human Neural Stem Cells Restores the Impaired Subventricular Zone in Parkinsonian Mice. Stem Cells 2017 35 (6): 1519-1531.

(5) Wang X, Li D, Deuther-Conrad W, Lu J, Xie Y, Jia B, Cui M, Steinbach J, Brust P, Liu B, Jia H. Novel cyclopentadienyl tricarbonyl (99m)tc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. J Med Chem. 2014, 57, 7113-7125

聯(lián)系方式：

郵箱：wangxia1507@gmail.com

手機：15117924226

組內人員

研究助理：王霞聯(lián)系方式：15117924226

潘蒙聯(lián)系方式：13269677023

秘書(shū)：方虓聯(lián)系方式：13051168676

在讀學(xué)生：李春園（博士生）

劉浩田（博士生）

陳亞霜（博士生）

李靜穎（博士生）

羅士淇（碩士生）